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Pushing The Limits

"Pushing the Limits" - hosted by ex-professional ultra endurance athlete, author, genetics practitioner and longevity expert, Lisa Tamati, is all about human optimization, longevity, high performance and being the very best that you can be. Lisa Interviews world leading doctors, scientists, elite athletes, coaches at the cutting edge of the longevity, anti-aging and performance world. www.lisatamati.com
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Now displaying: February, 2020
Feb 20, 2020
Catharine Arnston is the founder and CEO of a company called Energybits which produces some of the world's best Spirulina and Chlorella products.
 
Catharine has a 30-year career as an international Attache for the Canadian and British Governments, publisher of an international magazine and founder of three startups. But in 2009 when her younger sister was diagnosed with breast cancer and advised by her oncologist to change her diet to an alkaline one because it would help her heal, Catharine put her career on hold to help her sister. In the process, she discovered algae, the most alkaline, nutrient-dense plant in the world that no one seemed to know about. Catharine knew algage would be a game-changer for the world if she could just help people understand it and so she founded her company Energybits.
 
Algae s a multi-billion dollar crop in Asia where it has been used for decades. Algae is endorsed by NASA and the UN as the most nutritionally dense food in the world. There are over 100,000 studies documenting its benefits, some of which include increased energy, improved focus, strengthened immune system, reduced inflammation, removal of toxins, enhanced longevity, improved sports performance, removal of hunger and revitalized skin and hair health. All this from a 4 billion-year-old, single-cell organism that has forty vitamins and minerals, the highest concentration f prten n the world, ne calres and one ingredient. The only thing wrong with algae is that it is virtually unknown outside of Asia. 
 
This podcast interview is set to help change that in our corner of the world By the end of this interview you will be rushing out to get yours.
 
Workout Fuel
Give your body the protein and micro-nutrients it needs to perform without sugar or artificial sweeteners.

The Perfect Travel Food
Bits are easy to pack and eat on the run. Whether you travel by plane, train or automotive, Bits have your back.

Daily Greens in One Minute
Making sure your family eats veggies doesn't need to be a struggle. Think of Bits as your daily greens insurance!

plate
No More
Hangry

Spirulina is a cultivated algae that has been consumed for thousands of years by the indigenous peoples in Mexico and Africa. It has the highest concentration of protein on earth - triple that of steak - as well as the second-highest concentration of an Essential Fatty Acid called GLA (second only to mother's milk). Spirulina is loaded with antioxidants and unique phytonutrients like phycocyanin and SOD.

Chlorella algae are harvested in freshwater tanks and have been used for over fifty years in Asia. It has a remarkable ability to help remove toxins and help build the immune system. All naturally. Chlorella contains over 40 nutrients, including all the B vitamins, iron, zinc, and many minerals. It offers so many benefits we would never have enough room here to list them all.

"When it comes to nutrient density for omnivores, vegans, vegetarians and anyone looking to optimize their diet with dense quantities of protein, amino acids, fatty acids, DHA, antioxidants and more, you simply cannot beat chlorella and spirulina. But not all algae is created equal, which is why I swear by ENERGYbits® as my go-to algae source, bar none."

LAND
Algae produces 100x more protein than cattle and creates zero waste. This efficient nutrition protects our land.

AIR
Algae provides over 80% of earth's oxygen and even removes CO2. Thanks to algae, we breath deeper and better. Ohmmm.

WATER
Water is a precious resource. Algae farming uses 20% less fresh water than 
WORRY-FREE SOURCING

SAFE.
Energy bits grow their algae outdoors in carefully monitored fresh water tanks fed by triple-filtered spring mountain water. You can't find a water source or algae that is purer or cleaner.

PURE.
Energy bits use sound vibrations to crack our chlorella, passing the chlorella through a sound chamber. Most chlorella companies use an older technique to crack the chlorella. They tumble it with glass beads that leak lead into the chlorella.
 
If you live in the USA or Canada use the code Lisa at checkout for a 20% discount at www.energybits.com.
If you are in Australia you can order from www.eatcleanlivedirty.com.au 
but the discount code won't apply.
 
We are hoping in future to bring this product to our NZ customers so stay tuned. 
 
 
We would like to thank our sponsors for this show:
 
 
Makers of Photobiomodulation devices that stimulate the brains mitocondria, the power houses of your brains energy, through infrared light to optimise your brain function.  To get 10% off your order use the code: TAMATI at www.vielight.com
 
 
For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com 
 
For Lisa's online run training coaching go to
Join hundreds of athletes from all over the world and all levels smashing their running goals while staying healthy in mind and body.
 
Lisa's Epigenetics Testing Program
Get The User Manual For Your Specific Genes
Which foods should you eat, and which ones should you avoid?
When, and how often should you be eating?
What type of exercise does your body respond best to, and when is it best to exercise?
Discover the social interactions that will energize you and uncover your natural gifts and talents.
These are just some of the questions you'll uncover the answers to in the Lisa Tamati Epigenetics Testing Program along with many others.
There's a good reason why epigenetics is being hailed as the "future of personalized health", as it unlocks the user manual you'll wish you'd been born with!  No more guesswork.
The program, developed by an international team of independent doctors, researchers, and technology programmers for over 15 years, uses a powerful epigenetics analysis platform informed by 100% evidenced-based medical research.
The platform uses over 500 algorithms and 10,000 data points per user, to analyze body measurement and lifestyle stress data, that can all be captured from the comfort of your own home
 
For Lisa's Mental Toughness online course visit: 
Develop mental strength, emotional resilience, leadership skills and a never quit mentality -
Helping you to reach your full potential and break free of those limiting beliefs. 
 
For Lisa's free weekly Podcast "Pushing the Limits" subscribe on iTunes or your favorite podcast app or visit the website 
 
 
Transcript of The Podcast
 
 
Speaker 1: (00:01)
Welcome to pushing the limits, the show that helps you reach your full potential with your host, Lisa Tamati, brought to you by www.LisaTamati.com.

Speaker 2: (00:13)
If your brain is not functioning at its best, and check out what the team at www.veilight.com do now, be like producers, photo biomodulation devices. Your brain function depends largely on the health of the energy sources of the brain cells. In other words, the mitochondria and research has shown that stimulating your brain with near infrared light revitalizes mitochondria. I use these devices daily for both my own optimal brain function and also for other age related decline issues and also for my mum's brain rehabilitation after her aneurism and stroke. So check out what the team do at www.veilight.com. That's V I E L I G H T .com and use the code Tamati at checkout to get 10% off any of their devices. Pushing The limits this week. I have a wonderful guest, uh, who you're about to hear from Catherine Ernston of www.Energybits.com. Now, Catherine is the CEO and founder of a company that deals with spirulina and chlorella.

Speaker 2: (01:18)
Doesn't sound very interesting, but I can assure you this interview will have your mind blown as to how beneficial spirulina and chlorella are for your health. Um, and we will do a really deep dive. There's um, did you know that spirulina has 64% protein, that it has over 40 vitamins and minerals, that it is backed by the United Nations and by NASA they use it for astronauts in outer space. It is an eco-friendly crop. It's got over 100,000 studies done on it, showing the different benefits of these, uh, blue green algae. Um, and the founder, Katherine Amston, got into this through her sister having breast cancer. And through that she decided she wanted to help her sister and started to look at the plant based diet. She started to look at what alkalizing diets were all about and she stumbled across Algie and found out just how powerful it is.

Speaker 2: (02:21)
And so for the past decade, Katherine has been on a mission to let them world know just how important the nutrients I'm involved with a spirulina and chlorella. So it's a really, really interesting conversation. Make sure you stay to the end. Right. I just want to remind you too, I have my book, we'll link this coming out and just a couple of weeks time from the time of this podcast. It's the story of bringing my mum back after a major aneurism and left her with massive brain damage and hardly any higher function left. And we were told that she would never do anything again and that she wouldn't be with us long at stage. My mum had no ability to speak to communicate. She had no memory. She had no ability to control any bodily function, so the lights were on and no one was home. And this is a book about the desperate search for answers and looking outside the box and everything, the protocols, the therapies, the doctors, the research that I did, uh, and the work that I've done with her over the past four years to now have it back to full health again.

Speaker 2: (03:25)
So it's really heartwarming and amazing book. I've spent two years in writing this book and I really hope it's going to help thousands and thousands, if not millions of people. If I had my way, there's so many people suffering out there from brain injuries who need to know. Um, and this is not just for strokes or aneurysms, but across the board, all different types of brain dysfunction, whether it be Alzheimer's, dementia, strokes, uh, concussions, uh, aneurisms, all of these things. Um, this is a real good book if you facing any of those things, but also for anyone who wants to know about mindset and mental toughness and overcoming massive challenges when the odds are stacked against you, um, and who hasn't faced situations like that. If you're a human, you sort of get check these things at life. So I'd really love you to go over and check that book out.

Speaker 2: (04:15)
It's on my website now available for preorder at www.lisatamati.com hit the shop button and that will take you through to my shop with my books and my jewelry collection. So make sure you check that out. If you do that now you would also get access to mindset you, which is my online mental toughness and emotional resilience course, uh, that's valued at $275. You'll get that for free if you order the book before it launches on the 11th of March, but only up until then. Okay. So make sure you go and do that now. Um, and I really appreciate that right guys over to Catherine Amston

Speaker 3: (04:53)
well, hi everybody. Welcome to the show. Once again, it's wonderful to have your loyalty back with us for another exciting episode of pushing the limits. Today, I have the amazing Kathryn Anson with me. How are you doing Catherine? I am a well and wildly excited for being here. Now, Katherine has been traveling for the last couple of weeks, then conferences, so and so have I. So we're both sitting here very tired but very passionate about what we do. So Catherine is in Canada, sorry. She is a Canadian but she's living in Boston. Um, and she is the founder and CEO of a company called ENERGYbits, uh, which, uh, is a company that deals with spirulina and chlorella. So we'll start there. Katherine, can you tell us a little bit of your background and why you ended up down the spirulina and chlorella? I know algae who knew algae could become the love of my life?

Speaker 3: (05:51)
Uh, well I, you know, I started with a traditional career. I have an MBA, was doing international business, blah, blah, blah. And then my younger sister in Canada in Toronto, uh, developed breast cancer. And fortunately her oncologist advised her to change her diet to an alkaline one because they said it would help her with her healing process. She was going to do the chemo, but they didn't tell her what it was or why it worked. So she called me. Cause of course I love my sister, but also I'm just a really good researcher. I probably should have been a scientist. I said I have no idea what I'll go on a diet is, but you know, I know how to get on the internet and we'll figure this out. And it turned out to be mostly a plant based diet because of the phytonutrients and mostly the chlorophyll that helped build your immune system.

Speaker 3: (06:34)
And so when you're doing chemo, having a strong immune system is critical. I mean it's important at anytime, but certainly when you're doing chemo. So she did change her diet. She did heal from her, uh, breast cancer and 10 years later she's still cancer-free. And in the process of helping her with her research, I read about 10 books on plant based nutrition. Now this is 10 years ago, nobody was talking about plant based nutrition then as they are now, it's mainstream now. And I was like this outlier and I said, I was crazy, blah blah blah. But I just saw the science. I said, no, this is, this is important stuff. Somebody should tell the rest of the world that, well I have no nutrition background, but I saw what it did for my sister. I know I can help other people. I'm going to give it a shot.

Speaker 3: (07:16)
I have no idea how I'm going to do it, what kind of education I'm going to get. But I gave up my 25 year corporate career for a year for a health coaching certificate. But you know, gave me a little bit of science. Um, after I graduated, I taught nutrition for a year at corporations and hospitals anywhere who would let me in, cause I put a curriculum together and to try to teach people how to, you know, to incorporate more greens into their diet. And I learned two important lessons from that. One is that everybody knows they do need to eat more greens and to most people either don't like them or it's too much work or their kids or their husbands won't eat them. So they're, they're stuck. So I thought, okay, if I'm going to help people get healthier, prevent all these chronic illnesses or recover from them, I've got to find something that's green, fast, easy, doesn't require any work.

Speaker 3: (08:11)
And back to the internet. I went and I started digging around trying different things and I found the algae. Now I found it for my sister originally but hadn't really dug deep into it. So I dug deep and I was like, Alison wanted landfall in the rabbit hole because I found out that algae is the most nutrient dense fit in the world. It's the most alkaline fluid in the world. It's the most studied food in the world. There are 100,000 studies documenting the various athletics, um, physical, mental, any aspect of algae. It pulls out toxins, you name it, but there's 100,000 studies. And the problem is this knowledge hasn't gotten out of the scientific community and into the consumer world, but it has an Asia where it's a multibillion dollar industry and they've been using it for 50 years. And you know, in Japan, they don't take supplements.

Speaker 3: (09:03)
They just take chlorella, algae every day. And I point out to people that in Japan they have some of the best longevity, the lowest cancer rates, the best skin and hair. And I think a lot, you know, some of it is I attribute to the algae. So when I started seeing how powerful algae was and how easy it was to take, cause you could just swallow it and you're done. Um, and you know, it's endorsed by the United nations as the answer to world hunger is adores by nationals, the most nutrient dense food in the world. And they feed as the astronauts. I thought, okay, that's it. I'm spending the rest of my life to help people understand algae because I think it's the last chance we have to get nutrients into our bodies at the same time. By the way, we're also helping the environment because it's ecofriendly sustainable and we can talk about all that as well. So it's been a very exciting, challenging ride because everyone in my family and my friends thought I was off my rocker, but, um, but I, and I was on a show called shark tank. I don't know if you're familiar. Yeah. And, um, they made fun of me of course. And they said, we don't think you're in love with being an entrepreneur. You're just in love with algae. And I said, well, you're right. I am in love with algae and if you knew as much as I did about algae, you wouldn't love it.

Speaker 3: (10:15)
Oh man. There I am. 10 years later, uh, I feel algae is my, my, uh, super child that I'm, I'm helping to coax into the world. Uh, and it's about to be discovered in a big way. In fact, um, here in America there's a, um, uh, fast, uh, food. It's healthy food. It's called sweet greens, very, very healthy chain. They've got a hundred, a hundred and some stores. And just today they announced that their, um, their, their biggest effort this year is they're going to create a kelp salad bowl. Kelp is, they said, wow. You know, 2020 is the year of Kelp. And of course, kelp is part of the algae story. It's all part of the same family. So it's like, okay, we're getting closer. I have to stop you there because you need five minutes. You've just given us a condensed version of 10 years and there's a number of areas we can go down the list.

Speaker 3: (11:09)
So, uh, we talking, so algae, so the blue green algae, we're talking spirulina in chlorella and in particular, right? We talking spirulina being one of the most perfect foods on the planet, the most nutrient dense. Is that correct? Yes. So, um, I'll step back a little bit cause it really helps me, it took me a while to figure this out. So I'm eager to share the simplicity of it. It's like anything, once you know how to do something, it's easy. But until then it's a big mystery, right? So algae is just another food group. You know, we have fruits and we have vegetables. algae is a its own food group and it subdivides into two subgroups. So let's take fruits for example. Um, you might have bananas and apples as two subgroups. Well, within algae you have, um, seaweed or kelp and micro algae.

Speaker 3: (12:02)
And then taking the analogy of the fruits with apples, there's different types of apples. There's granny Smith apples, there's delicious apples. Well within the micro algae category, there are two main types. There's blue green and green, and one blue green algae is spirulina and one green algae is chlorella. Now these two are really the only two that are harvested as a crop. So it's number one to point out that algae, spirulina and chlorella are not a supplement. They are a food crop. And also equally important is they are not grown in the ocean. They are grown and cultivated in fresh water. It's called a hydroponic. A lot of lot of farmers grow hydroponic salad and tomatoes. algae is the same way. It's just grown in fresh water. Now I mentioned this because there are thousands and thousands and thousands of other strains of blue, green and green algae all growing in oceans, lakes, swamps, warming pools, your aquarium.

Speaker 3: (13:08)
And those are all poisonous and toxic. So if anyone is listening to this and they, and they go online and they read about toxic blue green algae, yes. That if it came from the ocean, not spirulina or chlorella, they are not toxic. And the reason why is cause algae will absorb whatever's in the water. So if it's in a contaminated water supply, of course it's going to be toxic. And I spent, I've spent a lot of years making sure that because we sell our products from doctors and functional medicine and wellness clinics, so they needed to be sure ours was pure and clean. So we do third-party lab tests here in the United States by an FDA approved lab. We even test for neurotoxins. Well, I think I'm the only company, algae company in the world that proves that there are no neurotoxins that are algae.

Speaker 3: (13:58)
So I just mentioned this because people will go to the internet and they'll start Googling algae and they'll find some information about toxins and then there'll be panicked. And I want to assure you there is no, there are no toxins. Certainly not an R spirulina or chlorella because we grow them very carefully and monitor them and test them, but they're grown in fresh water. It's a crop, not a supplement. Gotcha. And now if we go into the breakdown of, of the spirulina in the, um, chlorella or as far as the, the, it's, it's packed with protein. It's packed with um, pretty much everything to sustain. When I, when I started looking into it, I'm going, well we actually, we don't need to eat anymore. We can just say spirulina. That's true. She didn't live forever on spirit and although the only nutrient it does not have is vitamin C, which is really interesting.

Speaker 3: (14:55)
But other than that, or not much vitamin D, but other than that, in fact I'm the one and I should put a press release about it. I would about this. I know, I noticed, I saw it years ago, I saw a chart that identified all the nutrients in mother's breast milk, especially all the amino acids. Yes. Gosh, that looks awfully familiar. And sure enough, I checked our amino acid profile in spirulina. Exactly the same aminos. Exactly the same portions. So, and that helped explain to me why in Japan if babies are born and they cannot digest mother's breast milk, the only thing that keeps them alive is spirulina and water in it. Now I understand it's because the nutrient profile is very similar to two mother's breast milk. But of course, everyone knows mother's breast milk is the perfect food after the age of two, it's a little tough to get right.

Speaker 3: (15:44)
And actually I was just, I've just been reading a study on um, uh, brace, smoke and its anticancer properties with the, uh, what is it? The LBM and the, the, Oh, there's the name of it. One of the, and I wonder if part of it is cause it say well, you know. Yeah. Um, so, uh, and we can talk to, I would like to explain to your listeners the difference between the two allergies because they, they do completely different things in your body. But just while you're talking about the cancer thing, um, as I mentioned, spirulina is a blue green algae and chlorella is a green algae. And the rate, the reason why they're called that is because spirulina has two pigments in it. The one that everybody knows is chlorophyll, which is a green pigment and that, and chlorella only has the green, but spirulina has another pigment in it that's blue and it's called phycocyanin.

Speaker 3: (16:34)
Now, the interesting, and we won't dwell too much on this, but the interesting thing about phycocyanin as it relates to cancer, is that it has what's called anti-angiogenesis properties. I know that's a mouthful, but basically what it means is that when there are cancers or tumors, they find a way to literally hijack the blood vessels to reroute them to feed the cancer or the tumor. And there are different nutrients that will stop that process. Cause that process where they hijack the blood vessels is called angiogenesis. And so something that's anti angiogenesis stops that process. And this pigment called phycocyanin has been proven to be able to do that. Well, if you have a blood cancer, obviously it's not going to help because there's no cancer or tumor. Everything else, it's, it's very powerful. So, um, but aside from that, spirulina is generally known as an energizing algae, um, and it has the highest concentration of protein as you mentioned in the world.

Speaker 3: (17:39)
Now, this is why in 1974 the United nations had a global conference on spirulina and, and endorsed it and it, and still does as the answer to world hunger because it has three times the amount of protein in it that animal protein. And of course it's a crop that you can grow. So it still is the answer to world hunger. And if I can get my company growing and we get to be as big as I want it to be like, believe me, that will be one of the things that I try to help accomplish in my lifetime is to teach other people in other lands to grow this, to feed their, you know, their countries and yeah, people. But so, so the reason why spirulina is so energizing, number one is it has all this protein and the proteins already in amino acid form, which means your body as an athlete, you know this, you have your, you already doesn't have to break down the protein to get access to it.

Speaker 3: (18:34)
And what's even cooler is that, and most people don't know this, but spirulina is technically a bacteria. It does not have a cellulous wall. So the reason why this is important, particularly for athletes is because again, there's nothing for your body to break down to get access to the protein and the other Koreans. So it's absorbed virtually instantly. And uh, so normally do you get all the aminos? It's loaded with B vitamins, which convert the glucose into energy. And it also has the highest concentration of iron in the world. Iron carries oxygen in your blood. It helps my body. I know. It helps your body. Yeah. Oh yeah. It's pretty cool. I can, I can go even geekier on the oxygen today cause I've got, you know, like a lot of athletes have anemia, like problems since runners, amino acids are a part of, you know, the, the things that I get my all my athletes on so that they can get access to it.

Speaker 3: (19:32)
So anything that, um, and, and since listening to you on, um, our mutual friend boomer, uh, Edison's podcasts, I've had my husband now who's training for an ultra marathon in four weeks time. I'm tasting this Berliner and his regime as it was for us, for his training, um, and finding fantastic results. And I've never, I never made the connection before between, okay. You know, I knew about spirulina, I knew the basics, but I didn't understand it could actually be the perfect food for endurance athletes. It is the perfect, we in fact field, so many Olympic athletes during the associate winter Olympics that I sent two of my team over to Sochi and because I'm Canadian and we were getting known by the Canadian Olympic teams, we had full access to the Canadian Olympic village and I had a previous Olympic athlete on my U S team here. And so we got complete access to the us Olympic village as well. So it was pretty, it was pretty cool.

Speaker 3: (20:32)
Uh, athletes who competed in that winter Olympics were metaled and they publicly, uh, I have declared, you know, the, you know, congratulate us for helping them get there. So it was, it was a pretty low, yeah, we interested to tastes of it more, uh, with your products and the, um, in the, in the super long distance. And endurance's which is my background and we train a lot of experts in that area. So how would, what sort of results you could get if you were doing like mega long distances? Cause uh, digestive issues are a major problem for ultra endurance athletes like GI pain. Um, jeez, because all your bloods in your muscles of course, when that's right in your yeah, it's not doing well as far as, so the big problem comes in, how do you get enough energy in while you're running for two days, three days, whatever the rice is.

Speaker 3: (21:24)
Um, and this could be a perfect solution for a whole, well, April, it is the perfect solution. And in fact, I used to speak at triathlon clubs about this and they used to at first nail me because they said, well, I don't believe how anything with one calorie per tablet can give me energy. So I had to do the deep dive in the science and I have all the answers. Why not only that, I have anecdotal evidence because I can give you a list of, you know, 20 ultra runners who were run a hundred miles only on our algae and water. That's it. Nothing else. Wow. And to your point about the, um, anemia, um, I've learned for a long time, there's something called the foot strike. There's something about when the athlete's foot hits of Ash halt, it causes the iron to dissipate. And it's a real problem for, for Addie.

Speaker 3: (22:18)
Yeah. Yeah. That's Brenner's, Vimeo, yadda. Well, this is my answer. I'm really excited because I have to have constant, um, like iron infusions. Um, Oh, Oh, Oh. And my, my, and I'm not alone in this problem. There are a lot of female athletes especially, um, who are always at the bottom means, and of course their performances in and P because you can't carry enough blood and enough oxygen and, okay. Well we'll, we'll get you hooked up with some our cause. So, so the, uh, so the spirulina, you also have to be sure you take enough of it. We'd say we recommend 30 tablets for someone who's going on a run. Oh wow. Okay. So you know, if you only take three or four or you can, if you're just a mild runner, you know, he can take three, four. But if you're going to do a, you know, more than three or four miles, we suggest the full 30 tablets and there is never, this is why the athletes love it.

Speaker 3: (23:11)
Not only do they get the energy, it's steady energy. It's not a rush. It's not a crash. It's just steady. It's not just physical, it's mental. Because you also know as you fatigue, the first thing that goes is your focus, but you never get stomach distress because it literally gets absorbed into your bloodstream before it hits your, your GI track. It's that because there's no, you know, selling as well. Yeah. Yeah. The protein is already in aminos and all the other, um, the iron and the B vitamins and they make it three. Everything is attached to the amino. Everything just gets absorbed so quickly. It's, it's, um, it's amazing. So it's also got a mega three. So does it have B12 or is the B12 missing? Yes, it does have. B12. Um, and I'm, I have to admit, I'm on the fence. I don't promote the B12 because I honestly don't know whether it's functioning as a B12, but it's there.

Speaker 3: (24:07)
Cause we do the, you know, the lab test and it does have a mega three, so it's a sustainable source of, of Omega three. And it's also vegan of course. excuse me. So, uh, it's, uh, it has things like boron, which helped with your, your, uh, mental focus in the telomeres, um, and helps with coordination. So there's, I have a document I'll send you that itemizes about 20 different reasons why spirulina is the perfect fuel in every single possible way. Um, so it's, yeah, it's, it's, it's super excited to try have half of our athletes and I've always seen what being like my husband obviously not dosing him up enough. I think I need to get more. Yeah. Well and, and you just, um, and so when you go on the long runs and then every, you know, hour, a couple hours, when you're starting to feel a little fatigued, take another 10 or 15 you'll, it's like anything, you kind of have to play around with it and see what works for your body.

Speaker 3: (25:05)
But in general, spirulina is that energizing algae helps with your physical energy, your mental focus. It satisfies hunger. So we have a lot of people who are biohackers keto, paleo who use it for intermittent fasting because it is ketogenic. It does not decrease your ketones or both. We've had a test that I was just at a Quito conference where I, I saw boomer, uh, and, and so it's very in embrace it also a lot of people when they're on the keto diet or they're not eating many greens cause they don't want the carbs. Uh, so this answers your solution cause there's zero carbs but it has the highest concentration of chlorophyll in the world, but you need to maintain your health. So it's truly the perfect food. And, um, as I say, spirulina, I will say it doesn't taste very good. So people either swallow it or put it into a smoothie. So that's your best way to, it's totally chewable. I, I do eat mine, but you know, it's my company and it's sort of like my dropped, so to sneak. So don't feel we, in fact, we have these sassy stickers that we send, we give out at particular, you know, some only select events, but then the sticker says it's okay to swallow.

Speaker 3: (26:25)
We have a sense of humor, right. Probably not as bad as much nutrients as both of those things. Well, you know, there is so much nutrition that um, even if you take five a day, it's probably more nutrition than your body is getting an entire week. It's that crazy. Yeah. So between protein and the 40 vitamins and minerals and all the B vitamins and the Omega threes, it's off the charts, the antioxidants and we, it really, it's off. The antioxidants was an interesting one. So it helps. So it can help your LDL your cholesterol, LDL and your triglyceride profile too, can't it? Yes. Yes. oxidation. I understand. So it can help reduce the oxidation effect that, yeah. Yep. Absolutely. And while we've had people who, who have the first normal blood pressure reading after even two days of taking the spirulina, it's that fast. Yeah. Yeah. It's pretty, Oh, all drug free.

Speaker 3: (27:23)
Noninvasive, just nutrient dense mother nature at her best. It's, it's pretty cool. Ready, simple answer. Like, so some of them were like a brain injury, like my mother. Um, what sort of like dosages would you say for here? Like if I had not been giving her enough? Probably. Um, and is it safe to go to a higher amount because it is only a food, isn't it? Yes, it, I tell people, well, you can't, you can't overdose on salad. Um, so we sell single servings of her of 30 tablets. And originally we were telling everybody to take 30 tablets a day or 30 tablets before a workout. Um, that's because we were working initially with elite athletes and that's how many it took for them to feel the improvements. But now we're really working with a lot of consumers who are very nutrient deprived. So any small amount will will make a difference. So we're suggesting three or four or five a day, but you know, feel free to take 30. And I personally have about a hundred a day and half for the last eight years. So, so there's no bloody good.

Speaker 3: (28:28)
You would be surprised how old I am. Um, so for my age, I do look very young. I was in LA recently and I took a sub, a train, a rapid train. I was in a suburb and taking the train to, into LA and um, seniors could ride for 35 cents and I qualified as a senior. I'm a senior now. Why? To go just and, and I'm very much like into the, like I'm, I'm, I'm getting old too. I'm 51 at the moment and I'm like, I want to age like a superstar. I don't want to give the normal aging things. I'm like, Oh no, it's not. I'm not, I'm not, I'm not aging gracefully and nor should you and I'm way over, I'm way over that. So, uh, so obviously you're doing something right. So blue, green algae.

Speaker 3: (29:28)
So chlorella. So, and also by the way, fear Lena was the first life on earth almost 4 billion years ago. Chlorella developed about a billion years afterwards. And it does belong to the plant kingdom, although technically it is not a plant. It's a sea vegetable because it doesn't have any phytates or um, any of the anti-nutrients that you know, that, um, can cause some problems with people. So it's, it's its own little category. So chlorella, unlike spirulina, does not give you energy, but what it does is it build your immune system and pulls out toxins. So it helps you cover from anything. It helps you recover from any kind of illness. In fact, it prevents them. Uh, and it does this in a number of ways. First of all, it has the highest concentration of chlorophyll in the world. Remember, that's what got my sister her. The oncologist advised her to change her diet to an alkaline one because of the chlorophyll which builds your immune system.

Speaker 3: (30:27)
Chlorophyll is a fat-based pigment. And why that's important is because your health starts at the cellular level. So it's the cell walls and the mitochondria. Now if the cell walls are not healthy and they need healthy fats to be healthy, um, that causes, um, disruption in your homeostasis and nutrients can't get in and toxins can't get out. So chlorophyll, you know that people always say how greens are cleansing. Well, this is what's cleansing about it. It's the chlorophyll that heals the cell walls. So did you can get in and toxins can get out and at the toxins. And if neither of that is happening, your mitochondria is suffer, your ATP is lower. You start to get rogue cells that don't communicate that which lead to cancer cells and it's a downward spiral from there. So chlorophyll is very important to maintaining your health. And there is nothing in the world that has more chlorophyll than chlorella.

Speaker 3: (31:22)
It even has 25 times more chlorophyll than liquid chlorophyll because liquid chlorophyll is made from alfalfa sprouts. It has a, I think 200 times more chlorophyll in spinach, a thousand times more than you know, cabbage. And I have this all on a chart from the Linus Pauling Institute showing all the different concentrations. Um, so, so chlorophyll very, very important. But in chlorella. Second, chlorella has never, I said spirulina has no celly. This wall with chlorella has the hardest in the entire plant. Kingdom is that hard cell wall that attaches to toxins and pulls them out. So oppose that led mercury. Aluminum athletes use it after any kind of sport because it pulls out lactic acid so your muscles aren't sore the next day. Um, people use it for, um, after drinking wine, beer or anything because it attaches to the alcohol. Well, the, the chemicals, the toxins that are released by the alcohol and pulls them out.

Speaker 3: (32:21)
So you are sober in an hour and a half and you never have a hangover. Seriously. I know. It's crazy. Good old chlorella. So it pulls out toxins. We have customers who use it to pull out excess chemotherapy after their treatments. You need to wait two days after your treatment because it will identify the chemotherapy as a toxin. And we want you to be sure to get your treatment and then pull it out. But they used it at a Chernobyl Hiroshima Fukushima, because in Asia, they all know that chlorella is the only thing that pulls out radiation. So in fact, after the Fukushima disaster seven years ago, the entire Asian supply of chlorella was bought up and there was nothing available for two months because it takes a month, bro and a month to dry and all that sort of stuff. So, um, so it's been documented, um, all around the world for pulling out toxins.

Speaker 3: (33:15)
We work with, um, a biological dentist who use it to, um, when they pull up, um, AMA grams because of course it's mercury and they use it for themselves as well as their patients. Cause of course they're inhaling the fumes from the feet. Wow. Chlorella also has the highest concentration of RNA and DNA in the world, which is important as you age because this will help your, your own RNA DNA to grow back healthier. It has something called chlorella growth factor, which speeds up the growth of yourselves. So if you injure yourself or have surgery that combined with the RNA and DNA and all the other stuff, you heal literally half the time. It's unbelievable. It's really unbelievable. Chlorella also has the daily requirement of a vitamin called vitamin K too. Now, listeners aren't familiar with K two. It's a very important vitamin only discovered 25 years ago.

Speaker 3: (34:08)
Um, they attribute a lot of heart, a heart disease and Alzheimer's to too much calcium in your blood vessels or your brain wrinkles in your skin from too much calcium. Um, uh, kidney stones. How much calcium, cause we're all taking calcium and we're all taking of calcium going into the softest. It's absorbed in the wrong places. Zorba in your bones. So what's happening is gathering in your soft tissue like your blood vessels, your brains and only K2 will activate the two proteins that move it out of soft tissue and put it into your bones. So at the same time, it prevents osteoporosis, which is a classic problem for, for women. Um, and the only places you can get K2 from naturally from food is grass fed animal protein. I know you guys have a lot of grass fed animals in New Zealand. Um, there's a disc called natto, which is a Japanese dish, which is really slimy and nobody likes to eat it.

Speaker 3: (35:06)
But I found out I did lab test. It's also in the algae, there's twice as much in the chlorella as there is in the spirulina. So it has your daily requirement of K2 in the chlorella. I mentioned this because, Oh, in general, I want people to understand that spirulina is an energizing algae and chlorella is a wellness and health and detox algae. It's a wellness LG. So if you want to recover from anything or prevent any illness, chlorella is your answer. Um, and spirulina will always give you energy and help keep you focus. So there's two of them. Yeah, I didn't understand that distinction. And I mean I've hooked into the, the um, vitamin D Kate in K2 and vitamin a, um, combination to get the calcium out of the soft tissues and then to the bones where it shouldn't be. Yeah. I didn't realize that the K2 was incorrect.

Speaker 3: (35:59)
So that's a real, yes. Well, I think I'm the only one that I think I'm the only one that knows that as I'm this closet researcher and I'll be, cause I need to know the answers. I need to know why this works so well because nobody else has explained algae the way that I explained it. And I could only, as you know, you only become um, you become a good teacher when you have dug deep into complex matters and then you, you find a way to simplify them for people. So I was, I needed to go through the complexity and now, I mean simplify them for people so they don't have to, but I have the research in case they want the backstory so they know that it's all legitimate and documented and all that sort of stuff. So I'm pretty amazing. And so in people, when people ask me when to take the algae, well you could take either of them alone, together with food instead of food morning, noon, night.

Speaker 3: (36:57)
However, in most cases people want energy in the morning and during the day, maybe before a workout, before an important meeting or a school or whatever. So take your spirit, you know, whenever you want energy and take your chlorella at anytime you want to eat it. Uh, but certainly at nighttime, because if you've done a workout, it will pull up the lactic acid. If you've had any wine or cocktails, they'll pull the alcohol out. Um, it helps your, your body goes through detox cycle when you sleep anyways. So this Patil is facilitates the detox. Speaking of which, uh, about the brain health. You know, when you're sleeping, your brain has a lymphatic system of its own. What? And so the important, one of the many important reasons for getting a deep sleep is it will not activate. And unless you're in that, I think Delta, whatever, again, number one sleep pattern.

Speaker 3: (37:49)
So, so it washes your brain. And so while it's cleaning out these talks as it's pulling out things like aluminum that caused things like Alzheimer's. So if you have the chlorella in your system while you're sleeping, it will facilitate that cleansing process, not only of your body, but of your brain. I mean it's going to happen anyways. But the true, you know, street washing, if you want to say of your brain occurs when you're sleeping, yes. Go. So it's important to have the chlorella when you're sleeping. I think every single person in the world should be taking chlorella every single day because, um, I was reading, there's something like 280 chemicals in America that have been released since world war II and about 200 of them, of the 200 have been tested. So there's, we're surrounded in our, in our air, in our clothing, and you've got to get those things out, uh, and were there also buried in ourselves.

Speaker 3: (38:42)
So, um, until you get rid of them, they're just going to cause silent damage and inflammation. So it's in all of us is adding to the aging, you know, we, we, we have in this society, we have this belief that aging is inevitable, but you know, like there's so many aspects to it. And if we tackle them one by one, I'm sure you know, if you're a divest Bree fan or not, I don't know. But yeah, not attacking all the different pillars of aging and you know, one of them being like this sort of stuff, getting into this stuff, getting the right nutrients and the right amounts at the right times and understanding we don't have to age like how our grandparents aged or even our parents age, you know, we've got a chance at it in this day and age that we can change our, uh, you know, the time that we are going to be healthy for and the time that we going to live for.

Speaker 3: (39:33)
And you and I being, you know, North of, uh, 40, both have a vested interest in making this crackly. Yeah. Well, um, the other good thing about chlorella is it actually tastes pretty good. So, um, particularly if you put a little sea salt on it or eat it with the best is if you eat it with macadamia nuts, which is great because macadamia nuts are loved by the keto community. And when you eat macadamia nuts and chlorella are at least ours, it tastes like you're eating potato chips. I swear to God, it is unbelievable. And so if you can learn to like my tastes pretty good with almonds as well, or banana chips or coconut chips or whatever, but the macadamia and the chlorella and a little bit of sea salt is the magic just snack guys. And not only is it a healthy snack, it's truly a healing snack.

Speaker 3: (40:27)
You can be pulling out toxins and you can be building your RNA and DNA and you can be cleansing yourselves at the same time. I mean it's, that's why I call it efficient nutrition. It can do all of these things so effectively in such small quantities like nothing else in the world. So it's pretty funny. I'm now starting to see why you are so passionate about, Oh, I know with all that responsibility to share this. So funny. You know like you, you with your sister starting off of the studio. I've been on a journey with my mom and ma and my own health as well. And you just like, you get the answers and this is why I do this podcast and you're like, I want to share this one. Everybody knows this. I go like dog. And so you like this, what we try to give your knowledge to, to people and to share it and, and you just can't have a big enough impact fast enough.

Speaker 3: (41:20)
I know, you know. Well, I'm so glad you know that podcasts have developed because people like you, um, have an audience that is eager to learn. I'm eager to, I'm eager to educate, but you know, the average person on the street doesn't want to learn. They want to go home and eat their crappy food and watch TV. You know, I don't even know. I haven't had a TV in 10 years. And it's like, why would you watch television when you can learn about the science of things that are going to change people's lives? I mean, seriously. Here may, I'm sitting on the plane in between conferences and I'm either listening to a recording from some scientific lecture or, or I'm, uh, reading something and every moment is filled with stuffing things in my brain. And sometimes it gets to the point where I have to actually stop and go, no, I am going to just watch a movie or something because the brain fried. But I'm like, uh, time is short and I've got so much to cram in there. Keeps popping out the other side. I know that, right.

Speaker 3: (42:25)
Well that is shining in that. And I'm so grateful to folks like you and also other vendors who are trying their best to get products to the community that wants to preserve their health or, or encourage their families to preserve their health. Because we're so surrounded with sugar and carbs and toxins and, uh, we have to be proactive too and take charge of our lives because nobody else is gonna do it for us. And ICP, all the people with walkers. And I'm thinking, that's not going to be me. So, yeah. And, and, and, and that's, we've, we've lived, we've grown up in a world where you were told, the doctor knows everything you're like of doctor is God and what they say goes in and, and this nothing, nothing. He gets doctors. Um, but we cannot give up a responsibility for our own health to somebody else because that busy, they've got a hundreds of patients, they've got 10 minutes to see you.

Speaker 3: (43:23)
They are definitely influenced by the pharmaceutical companies. You cannot rely on that as being the only place that you get your information to ask to be responsible. And we live in a day and age where we can be responsible, we can go, we can't access the studies we can. And not everyone's a science news like we are. Um, but you can still find some really good information even on a surface level. Um, and this is why it's important that people take ownership of their own health in ways we even eat better, get connected with nature, you know, understand what these rhythms in our bodies so that we can optimize it. Well, it's a, it's a great time because, um, uh, you know, I'm also a Reiki healer and I've just, I've been interested in nature all my life and, and it's, and I do yoga and I also do high intensity workouts and it's not woo woo.

Speaker 3: (44:15)
Like, it's just, you start to understand that we're all connected and if you treat your body, uh, holistically and the environment holistically, you will just feel better and you'll be more loving and you'll just, everything will work better. So anyways, I truly believe algae is part of that solution. Also from an environmental perspective because you know there are a lot of the oceans are being overfished for their fish oil. The algae. Where do you think the fish get the Omega three from? They get it from algae. They only can, yeah, that's where it comes from. So go to the bottom, the original source of the mega three, get it from the algae yourself. By the way, almost all um, fish oil goes rancid in the PR and the production basis three a day and the Omega three and algae never goes rancid. Speaking of which, our bags, we have to put an expiry date on it.

Speaker 3: (45:07)
So it's usually two or three years out, which is pretty long and its own right. But technically it never goes bad cause it's just a dried vegetable. And you could keep this for 10 years and open it up and still be fine. Absolutely fine. So mom, and that's because algae is a unique, um, as I said, it's not really a plant. Um, I read recently a group from national geographic went up to the Antarctic and they took a chunk of ice that was carbon dated to almost 4 billion years old. And they took it back lab. Yeah. And they, some of it in a Petri dish cause they saw some algae was attached to the ice and they, and they put on it and the LG started growing like over 300 years old and starts growing again because LG never dies. It just goes dormant. Isn't that crazy? It's amazing. So if we ate the LG thin, perhaps we won't ever die. It would be great to have people taking it because I'm going to live forever. So I need friends who are going to be with me, take my allergies. I'll have someone to hang out with.

Speaker 3: (46:11)
You got to have that attitude at least. So we can't lie. We can, we can do me and Dave Asprey will be the last one standing and stuff. And with the chlorella, I, um, I remember you saying on boomers podcast that it does have a hard cellular wall. So the way that it's broken down that cellular wall so that you can digest it as a human, um, has implications from where you should get your core hours. Yes. Well, thank you for mentioning that. So I, um, first of all, the whole, um, LG industry has started with chlorella in Japan and there's a company called sun chlorella that started this all but 50 years ago. And I'm very grateful to them because it took them 10 years to figure out how to grow chlorella for mass consumption. And they, and they, that they're the ones that found out that you had to crack the cell wall because it is so hard.

Speaker 3: (47:06)
Um, and if it wasn't cracked, your body would not be able to absorb the nutrients. So, uh, it still will pull out toxins, but you won't get any of the nutrients. So they developed and patented a technique called dynamo, which, um, virtually the entire industry uses, uh, chlorella industry because of course, spirulina has no cell wall. Um, and they, they tumble the chlorella with glass beads. Now what happens is the glass heats up and there was always concerned that led from the glass leaked into the chlorella and they always declined and said, no, that didn't happen. Didn't happen. But, um, about 10 years ago, just when I was starting the company, the state of California tested their chlorella and did find it had excess amounts of lead in it. So they said, well, you can either stop selling here or put a warning on your package, which is what they did.

Speaker 3: (47:55)
So by sun, chlorella and America, you'll see a warning on the package. But the bigger problem is it's not just them that uses this technique. It's virtually an entire chlorella industry. So when I started the company 10 years ago, I, I heard that this was a potential problem. And I said, there's got to be another way to crack the Corolla. We've got to find some, but some other way. And there was a new technique that had just come out and that's what we use. It's um, you pass the chlorella through a sound chamber and it's the vibrations that crack LA chlorella. It's very similar to how an opera singers voice can crack a class. So it's the vibrations that are cracking the cell wall. I told this to somebody recently and they said, Oh well your, your chlorella has good vibrations. Yes. Yeah, we're all, we're all buy, buy, buy, buy, buy bations cause I'm also a regular so I owe all about energy and I if you haven't, if your listeners are not familiar with dr Joe Dispenza, um, yeah, yeah. I would encourage you, cause DePaulo him as well is incredible. And we sent him some product actually recently. My dream is to have our stuff at his seminars. I hope to go to one soon. He's, he's, he is, he's unbelievable. Unbelievable. He, he has between him and algae, I think we can, we, we have a future, we have a future and maybe add in a couple of others. Like I'm Dr. Bruce Lipton and divest and yeah.

Speaker 3: (49:30)
Yeah. Oh man, those guys, I, I'm so grateful to them. I've been reading their books for 20 years and I'm now getting to learn even more. And it all makes sense when you start to read about these different techniques and what everyone's doing. It all starts to make sense. So, and this is an exciting age to live in and I, we're getting off track, but the science is catching up with the Woodward community community where it was considered, you know, these, some of these things were considered like Reiki and like other things. Then it was a bit off the beaten track and no science. And now the science is actually proving a lot of the Eastern rights and things and you know, Chinese medicine, Ayurveda, medicine, um, course, you know, acupuncture, all of those things. And now I've got scientific backing that they are actually, um, and this is a really interesting convergence now and that's what I loved about Dr. Bruce Lipton's work toe was he actually managed as a, as a molecular biologist to connect the spiritual world.

Speaker 3: (50:30)
Even with the cellular bio, you know, biology and epigenetics. It was a visit and sign book there. The biology of life. I love that, that book. Um, and to see it all coming together. And I think as we get into quantum physics and things that are coming up down the road, I think, wow, you know, there's into the quantum realm, it's going to probe. A lot of these things have real value in real science behind it. Well, and as a small segue, that's one of many reasons why I'm in love with algae. Cause I tell people, Hey, before algae earth was just water and gas, there was not anything living on earth 4 billion years ago. Now I don't know why spirulina showed up, but it did. It's a single cell organism. And after, and it releases, oxygen was growing. So after a billion years, it released enough oxygen that other life forms could, could grow, which brought chlorella, which then brought more oxygen to earth, which allowed more life forms.

Speaker 3: (51:31)
And then eventually we had life in the ocean. And then we had terrestrial life. And then the old, only 800 million years ago did life. Humans show up. But there's gotta be, I think there's something mystical about allergy because it was the first single cell life on earth. Um, and it's still here and it's, you know, they would prove that it's got something about it. It doesn't die. It doesn't, you know, it's, it's been around a long time. They might be something more to it even then than the size of it. Right, right. So I, I'm Kiffin I know you're, you're, you're extremely tired and busy. Um, I'm gonna wrap it up there in a moment, but I, I just wanted to talk about where people can get your product and make sure that they're getting a good quality supplements. And, um, Catherine's been doing this way obviously for a very long time.

Speaker 3: (52:24)
A new company is energy buts.com. Um, and so anybody who's in America, Canada, we're asked you ship to, or we don't ship internationally, although ironically, we stopped shipping to New Zealand and Australia and we have a, um, a distributor who has a lovely couple, uh, Chris and Fria, they have a website called, uh, eat clean, live dirty.com. Dot. A U and they sell our products through their website, the eat clean live durney.com dot. A U. But if you buy, if you live anywhere other than a event that's usable and for Australia, you can buy from our website energy bits.com and we ship internationally into Canada, obviously throughout the U S uh, and when you shop on our website and use the discount code, Lisa L I S a could be uppercase or lowercase, it doesn't matter. Then you get 20% off your purchase and it works on everything all the time. But that's only on our website. Not that you need energy, but unfortunately Kiwis and Aussies, you have to just support the um, uh, eight clean lifts, dirty a website and you don't get the discount. But if you do, if you live in the States or Canada or anywhere else, you can get a 20% discount. So that's a really, really con thing. Thank you very much Catherine for that.

Speaker 3: (53:52)
And I'll, and it's very concentrated, so it's very high quality. If you also live in the United States, you can purchase from Amazon. We sell everything on Amazon, no discount codes work. And also on Amazon, we sell little pouches that have 30 tablets. On our website. You can only buy large bags that have a thousand tablets or boxes that have single single servings. But on Amazon you can buy for a $4 single serving and tested out if you'd like before you met to a large bag. And um, I'd also encourage people to come and visit us on Instagram. Our handle is at energy beds. Same with Facebook, it's in it at energy bits, um, or Twitter. And if you come to our website, you'll see we have two brands of spirulina. One is called energy beds, but we have a second brand of spirulina called beauty beds because it also builds your skin and hair health.

Speaker 3: (54:41)
And we wanted something that would be appropriate for spas and a little bit more girly, but it's exactly the same product, just different packaging. And then the chlorella we talked about, that's called recovery. That's, and then we have a fourth product called vitality bits, which is 50% spirulina, 50% chlorella in general, particularly if you're an athlete. We encourage you to buy them separately because you want to split, you know, load up on the spirulina before your workout and during your workout or run. And then you want to take the chlorella afterwards and then, or if maybe you had a little extra to drink extra chlorella or maybe you've got, you're sick and you're detoxing extra chlorella. But that way you have more control over the two different allergies cause they do completely different things in your body. That's important distinction because I didn't understand that really.

Speaker 3: (55:30)
So that's, that's really good. So endurance athletes, go and get your spirulina and chlorella and do it separately and have the S the spirulina before your workouts, the Corella after or in the evenings to you repeat it. So www.ENERGYbits.com I'll put the show notes. Of course you can get on my website, at least@tammany.com on the podcast, under the podcast button. We would have this all available for you. Um, and if you want to reach out to Katherine, can they reach you somewhere or just by your website? Yeah, they can. The customer carrot energy bits.com. I've written about a hundred papers on different aspects of LG white helps with different things. I'll send you a ton of stuff, Lisa, and you can put, you can post things. I'll send you a PowerPoint about widescreen for athletes. Um, yeah, like I said, we were, we were a sports nutrition product when we first started because the runners discovered us and then they told everybody else and that was that. And we'll, we'll keep spreading that word to the runners down on Stan, the sins of the world. So Katherine, thank you very much for your time today. I really appreciate it. I know you're super busy lady. Um, wonderful that we're connected. I'm sure we'll stay connected. Um, so yeah, all the best with your big mission in life to solve world hunger. And I tell people we're tiny but mighty and you will be too when you do geology. Fantastic.

Speaker 1: (56:53)
That's it this week for pushing the limits. Be sure to write, review and share with your friends and head over and visit Lisa and her team at www.lisatamati.com.
 
The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional.
 
Feb 13, 2020
Molecular Biologist Dr. Keith Booher talks about the Horvath epigenetic clock and the why and how behind finding out your biological age.

Keith Booher received his PhD from the University of California, Irvine in 2011 where he conducted research in the field of cancer cell metabolism. He then began work at Zymo Research Corporation developing methods and assays for the investigation of epigenetics. Along with colleagues, he contributed to a high impact study evaluating methods for DNA methylation validation in 2016.

Keith continues to study epigenetics in his current position as Application Scientist at The myDNAge company or Epimorphy, LLC, in Southern California where his research is focused on healthy aging and longevity.

In his free time, you can find Keith either on the dance floor, at the local library, or spending time with his family.

"The world population is aging, especially in the West and the industrialized countries of Asia. In fact, the percentage of the population over the age of 65 is expected to more than double by the year 2050. An aging population presents many societal challenges as advanced age is the number one contributor to chronic ailments such as heart disease, cancer, neurological disorders, and more. It is imperative that meaningful and effective anti-aging interventions are identified and deployed in order to ease the transition from a younger to a gradually older population. Epigenetics involves the modification of gene expression without changing the underlying DNA sequence. Importantly, many recent scientific studies demonstrate the connection between epigenetics, especially DNA methylation, and aging. To date, analyzing changing DNA methylation patterns at key genes is the most accurate way to quantify the aging process. Understanding the connection between epigenetics and the aging process allows us to gain deeper insight into the mechanisms that cause aging, with the ultimate hope of devising interventions that will potentially lead to better health and longevity. 
 
Dr. Booher highlights the use cases for this new type of testing and it's used for those individuals or teams wanting to understand what protocols, training regimes, food plans, supplement regimes etc impact their own aging and how you can maybe even turn back the clock ticking on us all.
 
Get yourself tested and find out your biological age at: https://www.mydnage.com/
Use the code 'LISA15" to get a 15% discount on the cost of the test
 
Watch Dr. Keith's Ted Talk 
https://www.youtube.com/watch?v=PeT1RcwsDMc
 
 
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Transcript of the Podcast: 
 
 
Speaker 1: (00:01)
Welcome to pushing the limits, the show that helps you reach your full potential with your host, Lisa Tamati, brought to you by Lisatamati.com welcome to pushing the limits.

Speaker 2: (00:12)
Let's see everyone. Thanks for joining me again today. I have a scientist to guest on the show, Dr. Keith Booher. Now, Dr. Keith is a molecular biologist and he works for a company called mydnage.com. Now this is a company that uses Dr. Steve Horvath's epigenetic clock. This tells us our biological age. So we have a very interesting conversation around the difference between your biological age your, your chronological age, and also the method of telling how old you are based on your DNA. So we're looking at DNA methylation as opposed to some of the other processes that look at biological aging from other factors. And we get to into a deep dive about looking at your biological age. Now this is really interesting from a perspective from coaching, from I'm trying to draw a line in the sand to see where you are now.

Speaker 2: (01:08)
And I can see this having benefits. We are looking at it for our mastermind program where we're thinking about having this as our baseline to start from where we can actually see what your biological age is at one point in time when you start. And then using that as we go through our program to see how you come out at the other end. And hopefully you would have lost a number of years off your life as far as your biological ages going. So this was a very interesting deep dive into this topic. So I hope you enjoy the show. And just before we go over to Dr Keith just like to remind you that I have my book relentless coming out in just a couple of weeks time or four weeks time and it's on the 11th of March and launches, it's available for preorder now you can jump on my website, hit the shop button and preorder it.

Speaker 2: (01:57)
And at moment you'll get access to my mindset Academy mindsetu for free. If you join or buy the book in the preorder stage, you'll also get a discount. It'll normally be retailing for $35. You'll get it for $29 plus you get access to mindset, you a value of $275. So really good idea to go on and jump and now and get it. And that helps me get the book rolling, get it out into the world. It's been a two year long process. So really excited to see that baby launch. As always, reach out to me if you've got any questions on this episode or on any of the other episodes that we've recorded. And I really appreciate your help with ratings and reviews on iTunes that really helps the show get exposure and of course sharing it with your friends and family if you got value out of it. So thanks and now over to Dr. Keith Booher from mydnage.com.

Speaker 3: (02:49)
Well, hello everyone. Lisa Tamati speaking and here I'm pushing the limits. I thank you once again for joining me today. I have a wonderful guest, Dr. Keith Booher who is a biochemist. Is that correct case?

Speaker 4: (03:02)
Yes, that's correctly. So thank you for having me.

Speaker 3: (03:04)
Yeah, it's wonderful to have you. So Keith is going to talk to us today about the biological clock. He works for a company called mydnage which does testing of the biological age as opposed to your chronological age. And this is a very interesting area we in our company through it continued existing without athletes and clients. So this is something that I'm very interested in finding out more about in cases coined the agreed to come on the show and talk to us about it. So. Okay. Can you give us a little bit of background about who you are and where you come from and, and the work that you're doing?

Speaker 4: (03:46)
Yes, certainly. So, so my name is Keith Booher. I'm a scientist. I worked for the company epi Morphe that offers the mydnage test. This isn't a epigenetic, a base test to quantify aging or biological age. And my background I got a PhD in biological chemistry. I'm from the university of California, Irvine here in Southern California right now. They've worked and where the company's headquartered. I then joined a research companies. I'm a research, Oh, also in California when I started doing epigenetics research in an industrial setting and then transitioned to a, working with the epi Murphy and offering the mydnage test.

Speaker 3: (04:28)
Wonderful. So can you tell us a little bit, well, for the listener, what is epigenetics and the area of study of epigenetics and what is on those a biological clock?

Speaker 4: (04:39)
Yeah, so I think, so the scientific, no definition of epi genetics, so it's a biological term. So simply refers to any changes in gene expression that occur without altering the primary DNA sequence. So what that sort of means in lay context is any, any instance where our genetics interacts with the environment. So sort of nature versus nurture a concept. So what epigenetics then does at the molecular level is to help control gene expression or to help turn genes on or off, or how strongly genes are expressed in the cell. I think an analogy that I've heard before, which is it's not perfect, but I think gives you the idea would be that our genes, our genetics, it'd be the hardware with which we operate. And epigenetics would be the software or instructions that tells that hardware what to do.

Speaker 3: (05:33)
Wow. Okay. So, so in other words, our environment, what we eat they, the, the, the, the toxins in our environment. Eric's the size, whether we do any or not, all of these things will have an effect on how our genes express themselves. So we've gone as sort of DNA code, which we can't really change. Yeah. What genes are turned on and off can be affected by environment. That, correct.

Speaker 4: (05:58)
Yeah, that's absolutely correct. So there's lots of studies looking at how epigenetics change in response to environment. So this, you know, in the past decade, decade and a half, there's been a lot of progress made by the scientific community. So we know that you know, people that go on a controlled exercise regimen you know, when they start versus a, when they stop after six months and compared to control group. So there are genetic changes that, that occur in a skeletal muscle. So we know that people have also looked at adipose or the fat tissue and also seeing epigenetic changes in response to certain exercise programs. We also know that smokers have a different epigenetic, I'm marks highly correlative with smoking. Mmm. That these epigenetic marks behind people in certain occupations where they're exposed to a lot of environmental pollutants such as coal miners, a certain factory workers also have pronounced epigenetic changes compared to those that aren't occupied in such fields.

Speaker 4: (07:04)
I think another, sorry, maybe another example just to really, it would be easy to understand is if you look at twins. So twins are genetically identical individuals. However, through the course of their lives. So we know what, you know, when they're young, we can take it classmates in grade school with some twins. I mean, you couldn't tell them apart. Right. But if we think of older twins, you know, throw the course of their lives, you know, they maybe move to different places there obviously the families that they no start you know, they have different sort of traditions, different diets perhaps they like to eat, you know, brought in from their own partners and all these different influences impact their epigenetics. Right? So these still genetically identical individuals but the epigenetics change based on their environment and their lifestyle and when they're older, they actually don't resemble each other as much as they did when they were. Yeah, sure.

Speaker 3: (07:59)
That's really good example of, of, of the, the power of epigenetics isn't it? I saw a photo of a pair of twins that I think were on the Oprah Winfrey show years ago. And two ladies, one very, very overweight one, one not and the identical twins. It's a really, it's an easy way to understand how much your environment fix your epigenetics of fakes your and how you end up. So in other words, we can't just blame mum and dad and our ancestors for what we've got. We have some responsibility for how we tune out. Is that right?

Speaker 4: (08:37)
Yeah, that's right. And I think it's it's actually allows us to take control and you know, kind of dictate where we want to be so we can, we're not destined for some, you know, fate just based on our, our genetics. We, we can actually influence what those genetics do.

Speaker 3: (08:55)
Yeah. So is this so I'm, I, I've read a lot of Dr. Bruce Lipton's work and books. And you know, I have found this whole area really, really fascinating and it's pretty new, isn't it? In the scientific world, like we're talking what the last 30, 40 years or Mmm. Oh, that, that scientists have really understood that the, it's not just your DNA that makes you who you are. Is it pretty new field?

Speaker 4: (09:22)
Yes and no. So I think we're all familiar with the Charles Darwin and in his theories on evolution. He's one of the preeminent scientists, the modern world. Actually before Darwin, there's a French, a scientist and philosopher, a Lamarck who, you know, he actually predicted that the, you know, wow. What are our, our parents or the mother and father the type of lifestyle they live. Okay. Their environment will impact. Mmm. The children. So it's actually a heritable trait passed on just based on, so he said that if you were, if your parents, did you follow with a blacksmith, you know, all the hard work that makes them strong will then be passed onto to his children. Mmm. And like a giraffe that you know, needs to a stretch to reach the the leaves from on the tallest branches of the tree will, you'll get a longer neck and then that'll be passed down for the next generation.

Speaker 4: (10:17)
And this is, this is a way that, okay. Drafts have evolved. Mmm. Once Darwin's theories came out and were tested you know, Mendell then proved how genes, I kind of demonstrated how James can, can, can behave. A lot of the marks, theories were just you know, kind of put in the, the dustbin of history and he was sort of left off, you know, these were, these were sort of thought as ridiculous principles, but a sure enough, as you, as you just mentioned, Lisa, in the past several decades, actually, the Mark's original theories have been proven to be a, have a lot of Yeah. He was before his time. And we know this to be true. I mean, the, the biology is clear that and then we're learning more about it all the time. And even in I think 2014 as these studies were coming out more and more showing the power epigenetics you know, a portrait of what Mark was on the cover of nature magazine and they kind of featured and, you know, paid homage to his, his original theories.

Speaker 3: (11:15)
Wow. What a shame. He wasn't around to say that a bit. That would have been the kinds of a lot of things. So in other words, so when we're talking evolution here or intergenerational . I, I read some way that, for example, when a mother smokes and the baby's in the, in the womb, that that can affect the baby's DNA and then it can affect also who children's DNA. Is that correct? The intergenerational nature, or is that a Zeta? It's not, is it epigenetics or is that more genetic changes?

Speaker 4: (11:54)
Oh, well, so any genetic change that's altered in a, what we call the germline. Oh, you know, the the male gametes are the chemo sites. That's certainly genetically heritable changes that occur in our you know, the scan for example, know if we know examples that give rise to cancer or something don't. So those wouldn't be heritable. Right. So like if something like skin cancer epigenetics, then, so, so for it to be heritable, it has to occur in the germline so that that would be the same for genetics or, right. Yeah. So we, so certainly genetic change is hard. I mean, that's, that's very clear. Epigenetic is it seems to also be true. There's lots of circumstantial evidence. It's very difficult to do these studies in humans for obvious reasons. Hmm. Other studies and other types of model organisms, the biologists often used to study different phenomenon indicates that indeed epigenetic inheritance inheritance is, is a observed phenomenon. I think it's very strong evidence in plants. I mean, these, these, these traits are, I mean, they persist for it. Dozens of generations in mammals, you know, maybe more temporal. So two to three or even four generations, but not not, not that stable, but it appears that they are here.

Speaker 3: (13:16)
Wow. Okay. So so we can affect our whole, yeah, the intergenerational aspect of it is quite interesting, but if we, if we just back up a little bit now and go into the dr Steve Horvath's work in the Horvath clock and I believe that is the basis of the work that has his work is the basis of, of the testing that you do. Can you explain what dr Horvath discovered and what that means for biological age and what, you know, how, how, how we can use it perhaps?

Speaker 4: (13:50)
Yeah. So this biological aging or epigenetic aging clock. So dr Horvath I think is the worldwide leader in this research. So he originally published a study in 2013. There was actually another study that came out actually a little before his that did something very similar. So I should mention too, it, he's, dr Horvath is a professor at UCLA. Oh. Petitioning biologists, computational biologists. So what both these research groups did, so her about that UCLA and then another group led by Hannah at a UC San Diego. So both in Southern California. So what they did was they looked at the epigenetic, a data for thousands of individuals and the applied some complex statistical mathematical algorithms. And what they found was that there were patterns of a change, epigenetic change that occurs with age. And so by of tapping into these different patterns, they could develop a model that would predict [inaudible] predict age based on epigenetic information. So, so that's where the clock came from. So basically, depending on what your epi genetics show, you can then assign a biological age

Speaker 3: (15:05)
Without any information. On the individual yourself. If you can take just a drop of blood, you can actually say with, with pretty, hi Jackness call it 98, the single thing. How well would that individual is based on the work from dr Hova? So most people fall into this, this Linea Patton that would say, well, this person has these markers on the DNA before that person is the Savage, is that how it works?

Speaker 4: (15:42)
That's correct. That's correct. So I think there's one. So it's not, it's not just that you want to predict an age, but it's actually a signing up biological age. Yes. So I think that's a key kind of thing to keep in mind. So no, we talked about the twins earlier, you know, a few moments ago and we can see that some based on, you know, one was overweight and the other was more fit based on their lifestyle choices. So the did the choices that we make in our lives. So whether we exercise or eat a healthy diet other things, Mmm. Influencer epigenetics, which can turn in turn influence our aging. So we can actually have and accelerated aging compared to an average person or actually a slower rate of aging compared to someone else. So the Horvath clock measures that, that biology based on the epigenetics. So, you know, you may be 10 years younger biologically than your chronological age, which would be indicative of, you know, good health or good cause I've stopped choices you've made.

Speaker 3: (16:45)
Do you see big swings in the like, you know, 10 years or is it mostly that most people are in the, you know, within a year or two off via at their actual chronological age.

Speaker 4: (16:56)
So most people will be within a year or two. That's, that's Mmm, that's what you know, Horvath and others have shown. And that's what we see in our data. However you do see outliers. And I think every time we see a case where someone is okay, we do see 10 or, or greater years difference. Wow. It, it seems to be associated with, I mean, it almost in every case, there's some reason why. So some known this person may be suffering from a genetic disease or I think one thing common in, and you know, people we've looked at is, Oh, they've been treated with chemotherapy. So these are very powerful drugs that you know, obviously to, to treat cancer, but I have very strong side effects. I mean, this is very well known. These, you know, some are just not tolerated well at all. And we know these, these type of people have actually accelerated aging, very rapid aging compared to an average person. Mmm.

Speaker 3: (17:53)
Do you see the other way like, people who have lived a, you know, extremely good, healthy lifestyle with good food, good exercise not too much stress you know, 18 or more years younger than there a chronological edge.

Speaker 4: (18:08)
So I don't think just for lifestyle choices, I don't think we've seen a huge effect in that regard. But there we have seen some strong effect. I think for certain people are doing certain targeted interventions, it's a little more and just trying to eat more vegetables or run a little further. These are taking drugs. So I think Metformin

Speaker 3: (18:32)
hmmm

Speaker 4: (18:33)
There's one that's looked at very seriously for some of these anti-aging effects and we do see a pretty consistent, strong effect towards a slower aging. Yeah.

Speaker 3: (18:44)
[Inaudible] Is a, is an interesting one because it doesn't let up think though negatively the, the mitochondria. And, but, but it was a little bit confusing when I looked into just some surface level research on Metformin thinking, gosh, this sounds interesting. I want to have that. It, it produces more longevity, but it can damage the mitochondria. How would that work? Because your mitochondria, your rap part of this whole metabolic pertussis, I mean, it's probably too deeper questions to ask you, you know, but do you know why?

Speaker 4: (19:20)
Well, that's, that's a very good question, huh? The short answer is no one knows why. So, so yeah, there's sort of a antagonistic effects on or seemingly that would, that would associated with adverse health outcomes. But the data showed, we know it has been prescribed for type two diabetics years and has very good outcomes. And it seems to be off target prescribed for other melodies as well. You know, that the side effects are, are small. I mean, that's just based on you know, lots of people taking the drug. It seems that small side effects and clearly the benefits in most cases outweigh the whatever side effects may occur. Mmm. As to the reason why, I mean, it may be that the positive affects to regulate glucose metabolism, insulin,

Speaker 3: (20:16)
Yup.

Speaker 4: (20:18)
Maybe more important than the damage it causes or we have you know, just backup systems to deal with mitochondrial damage or stress that we don't have as robust. I mean, just as you know, living human beings that we don't have for when our glucose metabolism goes awry.

Speaker 3: (20:35)
So you know, that would be especially the case for, you know, people with diabetes or prediabetes. It has the same effect then on the healthy, you know the healthy person who doesn't have insulin resistance or any glucose

Speaker 4: (20:49)
Problems. So, yeah. So we get this, I get this question a lot. I would be very careful about just taking any drugs, you know, getting home from certain websites for example, I would, I would consult a physician for that. Yeah. Yeah. Cause I know your listeners are probably very interested on what types of things they can do to, to help them.

Speaker 3: (21:15)
Nobody don't go out there and do anything solid, not advocating this. We definitely won't. But, but it's interesting to look at the data. I know that there was a study done just a couple of years ago, I think by dr Horvath where they were able to reverse the, the epigenetics

Speaker 4: (21:33)
Clock

Speaker 3: (21:34)
In a small clinical study by giving people growth hormone and to diabetic medications, I believe. One. Mmm. And they took two and a half years off the year.

Speaker 4: (21:49)
Mmm.

Speaker 3: (21:49)
I'll say biological

Speaker 4: (21:51)
Age.

Speaker 3: (21:53)
That's, that's pretty exciting to actually be able to reverse. I mean, I know this was a small clinical trial and, and certainly not a big one. And obviously it's a very difficult area to do big blocks studies end, but a w would suggest that we're going to be able to in future reverse the aging process, which is super exciting rather than just slowing it down.

Speaker 4: (22:17)
Yeah. So this was the study you mentioned was a, that was a big one. So there's a lot of I don't know a lot, but there's a, there's a decent amount of studies you know, the Horvath and others have been involved in showing on ways to slow the rate of aging. But I was at a, a, a conference actually I gave a presentation along with the, dr Horvath was a keynote speaker and there was another, a surgeon Jim Watson. No. And Jim Watson said, you know, we think that we will be able to reverse actually reverse the clock. And Horvath was, this was January, 2018. He was pretty, he pushed back pretty hard on that idea. He said, you know, there's, there's nothing we found that can actually reverse aging clock. I, there's nothing in the data that shows that, you know, Jim Watson, he's a, he's a prominent Sergeant, you know, he works with patients and you know, from his medical person, he's like, well, I respectfully disagree. Yeah. And if you look at the authors on the paper, you mentioned Steve Horvath, but actually Jim Watson is, I think he's a senior author on that. Mmm. They ended up collaborating after this, you know, and [inaudible] looking into ideas from the medical side and then from, you know, dr horvath, you know, using this, these, these epigenetic aging clocks. And sure enough just as you mentioned, the study showed it was small, but it showed clearly that the aging was reversed to these individuals

Speaker 3: (23:39)
In a, in a very short space of time too, which is exciting to think what would happen if these interventions were, you know, extrapolated over a longer period of time. Mmm.

Speaker 4: (23:52)
Yeah. That's, that's right. I, you know, if you look at the, the intervention in that case, it was a drug cocktail. It was a two, two hormones, DTA I think human growth

Speaker 3: (24:05)
Yeah.

Speaker 4: (24:06)
And then I met foreman again was a drug they use to kind of help regulate some of the hormonal side effects of those drugs. And it was this three drug cocktail. Mmm. The the original goal of that study was to help reverse some of the immune decline. It had been well documented. We know our immune system starts to decline and as we grow older and the famous of course this organ that it functions in immune, you know, healthy immune function tends to get weaker and shrink. And so that's what the, the study was originally designed to just boost thymus function in the immune system. And okay. The authors showed clearly with, yeah, with, with clinical measurements, famous enemy and functions were restored and it was then shown, that's when Horvath came in and looked at the the epigenetics to show that actually reversed in these people who had responded well to the treatment. So

Speaker 3: (25:04)
Yeah, that's a short time frame as you mentioned. Yeah. Yeah. Very exciting. There's hope for us who are aging that we bought. So hurry up. You guys get started in so with the, the Magii and H test which people, you know, the public can go and get the SKUs. So if you wanting to actually, after listening to this episode want to go and just what your biological ages, I'll give you the address. It's just my, my DNA h.com. So DNA G a.com and you can order a test the and have the stun, which I, I'm, I'm finding fascinating from a coaching perspective and from an athlete's perspective to be able to draw a line in the sand and say, well, this is where we started from. And then we, you know, instigate L a epigenetic program for example, and our training regimes and nutrition and so on.

Speaker 3: (26:00)
And then perhaps in six to 12 months time retest to see what the I need a fake was. So I'm, I'm excited to be able to hopefully incorporate this into some of our, of our programs. And one of the reasons I reached out you today when we, let me go to the, look at the the testing that you do. So you're looking at the DNA methylation, is that right? Mmm. Can you explain what the United w what exactly that you're looking there with the, when you're looking at the methylation marks on DNA?

Speaker 4: (26:36)
Yeah, yeah, that's right. So we're looking at DNA methylation. So know anyone who wants to use our test, I might, do you need

Speaker 3: (26:44)
To test?

Speaker 4: (26:45)
We would send them a kit. Mmm. We would it comes with you know, slow land so we can take a blood drop. Mmm. That's put into a, you know, a special preservation stage or buffer solution.

Speaker 3: (26:57)
[Inaudible]

Speaker 4: (26:57)
Your preserve the integrity of the sample and then it can just be mailed back at room temperature. So it doesn't need to be frozen or cold or anything. I think also send a urine sample as well. So it's, it's, it's up to the it's each individual if they feel comfortable with, Mmm. That's sent back to us from the blood or urine sample. We will extract the DNA and then perform some fancy chemistry to quantify DNA methylation levels at a panel of genes that are known to be highly associated or highly informative of aging.

Speaker 3: (27:32)
Huh.

Speaker 4: (27:33)
Based on those values, we can then plug it into a mathematical model to predict the biological age. And again, this is, this is based off of a, you know, Horvath and others of the based on original publications. We sort of make it a economic one available too. And

Speaker 3: (27:54)
Sorry, Carry on.

Speaker 4: (27:58)
So we can make that that technology, which would otherwise not be accessible to non scientists. The general public, we can make it accessible to them. So they can, they can get their own biological age assessment.

Speaker 3: (28:10)
Yeah. It's really, really exciting. So, so you're looking at around 2000 different James. Mmm how do you, how do you express it? He was signs on there. They had assigned basically there was damage here. So you're looking at damage, Marcus.

Speaker 4: (28:30)
It's not, it's not famous markers per se. So specifically it's, it's DNA methylation. So a methyl group is a, you know, if you think from your organic chemistry, this is the most the oxidized form of carbon. A ch three is added to DNA and basis known as cytosines any basis on the cytosines. And when it's added biologically, what's going on at the molecular level is it's influencing gene expression. So helping genes turn on or off, on or off. Mmm. And these levels change over the course of our lives and it's this change that can then be related to, to, to the

Speaker 3: (29:12)
Marcus. Okay. I get that. Yeah. So does it take into consideration things like inflammation or cardiovascular health or kidney and liver function or metabolic metabolic state as well? Or is that readable from the DNA?

Speaker 4: (29:32)
Not with, not with the mighty age test. So if there's something specific like that, again, I'm in consultation with a physician. If you're worried about your

Speaker 5: (29:41)
Kidney health, metabolic health, Mmm. Then, right. You know, there's more specific tests to directly look at. Right, right. I think as a pan health indicator it gives you some information. Right. Cause I know that there is you know, other companies that do biological age tests that are based not on the Horvath clock, but on, I'm looking at these are the tops of biomarkers, like your inflammation, inflammation, they've always been your, your cardiovascular health. And I was trying to understand what is the difference in the, in the approach, you know, in the approaches and which one is, Mmm. Well going to give us some more exact calculation if you like. Do you know of the other ones and the difference between, well I mean, so there's, there's a lot, you know, people have been using like in a doctor's office, just a grip, the grip test, your vape.

Speaker 5: (30:39)
How will you walk? Yeah. The way you walk. But you know, there's a really broad era for those, for people you know, between the ages of teen until some point in your, your older years. Mmm. It's just not very, not very good. It's very precise, very precise. There's other molecular tests. Even if you look at DNA methylation or epigenetic tests, they may focus on a single gene or just a few genes having a, a more focused, you lose a lot of robustness so they can be more susceptible to small changes or small, Mmm. Environmental insults that may actually not have a big impact. So by incorporating thousands of sites into the tests, which, or my teenage test does, it's more robust to small changes. So overall picture. Yeah, that would be it. You know, cause when I heard about things like grip strength and stuff, I was like, well, if I got into the gym a lot, obviously I'm going to have a lot more grip strength.

Speaker 5: (31:39)
It doesn't necessarily, I'm biologically younger. Right, right. Yeah. Basically you say, I have a normal or we're better than average. Right. Or it's not good. Right? I mean that's, you get kind of a yes or no kind of a yes, yes. But it's not, it's difficult to say, you know, you know, you're looking at the also your body type, you know, like, and with your, you're a muscular person or you're a someone who is more of a flexible person, you know, there's, there's just too much. Okay. Wavering in the air. I mean things like inflammation markers of course. Can you look at the state of your health but perhaps notch the actual, you know, whether it's having damage, you mean you can have inflammation markers because you've got a cold as well, which would be skew the data satisfied. and a bad week.

Speaker 5: (32:35)
Yeah. And this wouldn't happen with the, with us taste. So how w I know you've done a Ted talk that I listened to that was very interesting thing and wants to look that up. We can put that in the show notes as well. We've got an aging world population and we have huge problems all around the world without, but their health care system. I think we probably can all agree with that. We're heading into times where chronic disease is going to be costing economically, governments in, in, in, you know, a lot of suffering around the world and a lot of resources. Mmm. So increasing health span is, is a very important piece of being able to lower the costs involved with chronic disease. Would you see that as being one of the areas where this this theory or science is really, really key and an important from a, from an economic standpoint as well as from the personal suffering standpoint?

Speaker 5: (33:39)
Right. Yeah, absolutely. Yeah. Right, right. I think the potential to benefit society is really there's a, there's a lot a DNA aging test, epigenetic aging tests can, can provide. So it is clearly the best tool, two, assess, aging accurate and precise way. Mmm. And so by using this tool, I mean, whether it's, you know, our company and our researchers doing, you know, in their own labs are their own ways. Mmm. Those interventions which will have the greatest benefit can be more rapidly identified and no, very okay track to be very cheap. I'm an actress. So this, I think this is, you know, beyond just individual testing, which I think is important. And, you know, very interesting people empower themselves by getting some information here, but broader for the broader impact it can have on society. It can be really profound. Yeah. And I know you've, you've done a little bit of work with you mentioned the, in your, in your talk you know, looking at things like sporting H, you know, like how if kids are really in the right age group or people who don't have documents working out how old they are.

Speaker 5: (34:56)
When they coming into countries perhaps as, as refugees without, without any paperwork and things like that. There's a, there's a, there's a whole lot of areas that this could be utilized and couldn't it. Yeah, absolutely. Yeah. So the the youth age testing I think that's, there's sort of a, the, the, the consequences are not as, as grave as like, you know, that aging population in Europe, you know, to some extent, North America and Asia. But but I, it just goes to show the potential applications for something like that. And I actually just learned that, you know, I did some work with [inaudible] law enforcement in Germany a couple of years ago for some for forensics application of using this aging. You can sort of the gauge person of interest in different law enforcement investigations. And in part thanks that work actually I just found out that lie in Germany changed December Oh about 2019.

Speaker 5: (36:01)
Sort of allow this scientific approach, you too well know wow. To work out someone's is being adopted in a lot of different areas. And I mean, Oh yeah. And, and for me I think in working in the, in the health as a health professional and, and training people and so on, it's just going to give us another, I'm wiping the Nantucket toolkit to get people motivated and moving and having a benchmark is really important I think for us to, well, this is where we started from and hopefully through different health interventions, we can see other results. Is there any way that we can, is there any of those things that are quantified, like what, what people are, you know, that are doing your tests perhaps and then doing different interventions, obviously not as a clinical study, but are you gathering any of the data of the interventions that people are undertaking to change the biological age?

Speaker 5: (37:01)
Let's see. What has it effect? So I mean, we have to be sort of careful about this, right? So that, I mean, the personal information of ours customers is yes. Obviously I can only do so much, right? I mean we're not, we're not trying to but so what I can say, we work with clinics, certain clinics doctors. So the doctors are incorporating this test into part of their medical practice and whether they're advising certain, you know, dietary interventions or different exercise programs or they can use this for their medical practically, I mentioned Metformin earlier. We are working with the group by testing this. So that's something that we, yeah, we can say has had a, yeah, a two. The rate of aging in these, in the samples, the subjects that we've examined. Mmm, yeah. Mmm. Yeah. Yeah. So that's got an interesting future too. I mean, what, what are you think, so are there any interventions which have been proven besides a Metformin and growth hormone? Mmm. To actually slow down the aging or to pervasive stop the aging process? Mmm, well that have been proven to be beneficial as it, you know, like lifestyle interventions. So yes, yes, there are. So, but I, I needed qualify that. So this has been clearly shown to occur in laboratory animals, so model research organisms and a lot of these,

Speaker 4: (38:34)
These pathways a

Speaker 4: (38:35)
Evolutionarily shared all the way from, you know, simple East to or complex organisms like fruit flies and more recently into mammals like mice lab, mice rats or even nonhuman primates. So there's clearly potential. Mmm. You know some of these interventions are related to altering metabolic pathways, insulin response. Mmm. Mmm. I think one that's gained a lot of interest in you know, the broader news media is this compound resveratrol. Yes. Resveratrol found in a grapes in higher concentrations, in certain nuts. I'm certain it's been shown to activate certain pathways related to protecting our DNA or protecting our genes and genomes and also influencing that metabolism in certain ways. So in laboratory animals, there's clear evidence to show that aging can be slow to reverse. In humans it's not as clear. So again, it's more difficult to do these types of studies.

Speaker 4: (39:39)
Okay. Ethical and logistical reasons. Yeah. But the Metformin is a hot candidate drug especially because it is well tolerated. So, so this may be something that can be easily prescribed. And individuals we mentioned the study that came out last last fall where the the growth hormone and Metformin combination reverse the aging in this was in a small court of men from the ages of 52 late sixties, I think. Years of age. Mmm. In terms of those are for reversing the aging clock. There's also evidence showing that the clock can be slowed from simple lifestyle changes. So if you think about diet, so it appears that, you know eating more plants plant based foods, so fruits and vegetables. So right carotinoids levels in the blood. You know, indicators of the.

Speaker 4: (40:37)
Okay. Metabolism are associated with slower rates of aging. Interestingly, a fish, actually, those who consume more fish, it seems to have the greatest impact on a slowing the rate of aging. Well, okay. That's interesting, huh? Yeah. Even greater than the vegetarian diets. That's what the data indicates at this time, at least. Right. Also you know, we can look at things that accelerate the aging clock. Mmm. So certain corn oil certain insulin levels a triglyceride levels you know, elevated or, or, or levels that are out of whack or associated with an accelerated aging. So these are indicators of a poor diet. Yup. I think one that's a, everyone's sort of interested to hear or happy to hear is that actually moderate alcohol consumption. It's associated with a slower

Speaker 3: (41:34)
Rate of eating. So, so we have an all glass of red wine with berry in it,

Speaker 4: (41:40)
I think. I think so. Yeah. Yeah. But this has been a also shown to have beneficial effects on heart health. So it's interesting to see that the studies our agreement, you know, coming back, coming at it from different angles, but, you know, finding beneficial health, mental health.

Speaker 3: (41:55)
So the, the things that we sort of intuitively know that exercise lots of fruit and veggies and you know, that type of thing. It can definitely slow down the aging clock. It's an exercise aspect of it as Sierra, any sort of data or omit, it's how much and what types of exercise or anything like that.

Speaker 4: (42:22)
So not that I'm aware of. So not that I'm aware of. But that's, but that's interesting. What you say is, you know, people hear this and they say, okay, great, eat more vegetables. You know, I already knew that. Right. But it's interesting the study, but I think you can see, right. So, okay, yes, vegetables are associated with slow rates of aging. So increase that. So it gives, we can show that in the data, but but what's really interesting about the clock of the state, but if you want, if there was one thing you could pick to slow your rate of aging, actually it's fish, right? So it's, it's a it kinda shows you you know, we can kind of rank these. So what's the most important thing? So, you know, vegetables are important, but actually according to the data fishes is even more important. Mmm. And you knew, and also people that die. While I've been doing vegetables, I've been actively trying to do better in, and so I've already incorporated that, but, well, what else is there that that might be, it might be missing. Oh, so a olive oil seems to be also beneficial. A dietary component. It can be incorporated absolute rate of aging. So, so what the clock does is it's able to quantify these and really pinpoint with some precision what,

Speaker 3: (43:33)
Yeah, yeah. Rather than just one out a feeling as and what we've, you know, at the top, some studies have seen what about ketones and the key she turned on us. Any, any data there on MCT oils or ketone esters or anything like that?

Speaker 4: (43:52)
Again, I'm not familiar with those studies. We haven't conducted any and we're not working with anyone specifically looking at this sort of thing that I'm aware of some. Again, you know, a lot of institutes and clinics are incorporating different things. We don't necessarily know what they're doing. I mean, it could be very well be that, you know, some of these changes are being prescribed or administered in certain way. I simply don't know the answer to that.

Speaker 3: (44:16)
Yeah, yeah, yeah. No, fair enough. So this is, you know, to actually get the data to get some concrete data is actually really, really helpful. And strengthening the arguments for reaching the goals and cutting out the, the donuts and the, the the biscuits in the sugar and so on. And, and the more data we have behind that, the beta what I had dr Andrew go Andrews on, on the podcast. We all would go, I'm looking at telling me and like something and NTA aging. Is there any sort of crossover between those sort of areas, like in the anti aging sciences in do you look at it telling me length is or anything like that in these biological tests or are they completely different area of science?

Speaker 4: (45:11)
It is different. It is different. So Tila mirrors have been I think before Horvath and Hanham's studies a few years ago came out showing the power of epigenetic aging assessments tumors were probably the most popular, well, I color test to look at this since then. You know, clearly that these DNA methylation clocks are by far the most accurate, most precise and robust to measure biological aging. Horvath and others tried to kind of assess how this interaction between Tealium or Lang and you know, epigenetic change and they found that they're not measuring the same thing. So they in the biology is they're looking at different things. And you know, I, I think for, you know, telomeres, you know, I just, in my opinion, I, I think they've been Sur surpassed by the power of the, you know, yeah.

Speaker 4: (46:07)
Inherent robustness of looking at epigenetics to assess aging. I think, you know, concrete example of this is so the telomere length, so the longer the telomeres, sort of the slower aging or more youthful, that's, that's the basic idea. And as those shrink, it indicates increased age or advanced age. That's, that's the basic idea. We find that this, you know, completely breaks down. When you look at something like cancer where a hallmark is the ability to increase the length of telomeres to kind of okay. You know, maintain the integrity of cancer cells or tumor size. And if you knew, if you look at it from that perspective, they would look biologically young. If you look at the same type. Okay. Tissue cancer tissue according to the epigenetic clock. I mean, these show very accelerated aging. So it's, it's clear indication of it for health. The telomere tests wouldn't be able to show that at all. You were so good. Sorry. Okay.

Speaker 3: (46:59)
Thats Really you know, emerging area of science that that's, I'm going to be interesting in the next few years to watch. Mmm. Keith, thank you so much for your time today. Is it, I, I think we've, we've, we've covered quite a lot of ground. Do you think there's anything we've missed out that, that people should hear about? In regards to doing, you know, like doing mydnage test can you actually, because we're sitting in New Zealand and obviously a lot of my lessons are in Zealand and Australia. Can you do the test from that far away when you're going to be seeding it in the post?

Speaker 4: (47:33)
Yes. So the test, so I think we're just trying to get the but just logistics, business-wise, just the paperwork in order too. We've gotten a lot of demand in Australia, New Zealand, you know, it should be a broadly. Yeah. Currently we're only offering and North America, Mmm. In Europe. Mmm. Canada, U S and . But we're trying to get to a New Zealand, Austria. That should be soon. So any listeners in New Zealand or thereabouts, that should be available very soon. Technically there's no issue. So the once the kids arrive the blood or urine sample can be mixed with the preservative solution. This is preservation. Yeah. Shipped back to our labs in California at room temperature with no problems.

Speaker 3: (48:22)
Nice. So we should be through that. Still already the tastes, even though you haven't got the laboratories and stuff down here, we came can already, you know, through that and seen it. But look, thank you so much for your time today. I think this is a really interesting area of science. And I'm encouraged people to think about doing these tastes because, you know, I will give you a line in the same tree to motivate you. I think a lot of 'em, you know motivation is a big key to being successful in your, in demons to be better and stronger and be there and plaster and normalize going to good things and tuning the, we're slowing down the clock with tuning back even. So having tastes like this that are available to the public, the weekly is exciting. You know, I think it gives us another thing that we can do that we can then use to help better our lives, you know, as we, as we move forward.

Speaker 4: (49:20)
Yeah. That's the mission of you know, making this test available to the broader, the broader public,

Speaker 3: (49:25)
The more things that are available direct to the public, the there or my opinion, it's not dangerous and you know, but being a bit of a biohacker, obviously I have a bit of a, a boss towards having your own power and making your own decisions. But I think this one is a, you know, it's a no brainer. It costs so obviously, but apart from that, if you you want to try this out I'll have the links in the show notes and case thank you so much for your time today. I wish you well with all your studies and with loved side contact and yeah, very, very interesting conversation today.

Speaker 4: (50:03)
Oh my pleasure. Lisa. It was great to, to speak with you. Thank you very much.

Speaker 2: (50:07)
If your brain is not functioning at its best in checkout, what the team at vielight.com Do now being like producers, photo biomodulation devices, your brain function, the pin's largely on the health of the energy sources of the brain cells. In other words, the mitochondria and research has shown that your brain with near infrared light revitalizes mitochondria. I use these devices daily for both my own optimal brain function and also for other age-related decline issues and also for my mom's brain rehabilitation after her aneurism and stroke. So check out what the team do vielight.com. That's V I E L I G H T .com. And use the code "TAMATI" and checkout to get 10% of any of their devices.

Speaker 1: (50:58)
That's it this week for pushing the limits. Be sure to write, review, and share with your friends and head over and visit Lisa and her team at Lisatamati.com.
 
The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional.
Feb 7, 2020

Geoffrey started off as a computer scientist after graduating from Stanford but after creating a successful start-up that sold to Groupon, a public company he decided to change the trajectory of career and used his incredible intellect to learn more about optimising human performance at first concentrating on enhancing cognitive performance through Nootropic stacks and then delving deep into the science behind the keto diet, intermittent fasting, metabolism, ketone esters and supplements.

He is the founder of the company H.V.N.M (Health via modern nutrition) that licenses the world's most advanced keto ester developed in conjunction Professor Kieran Clarke of the University of Oxford to develop H.V.M.N. Ketone Ester, the world's first ketone ester drink, based on Prof. Clarke and Dr. Richard Veech's (NIH) seminal work on ketone esters and exogenous ketones.
 
Geoffrey is a serial entrepreneur. He previously was CEO and co-founder of Glassmap Inc., a software technology company backed by YCombinator, a top venture capital group
 
In this conversation, Lisa and Geoffrey discuss the power of intermittent fasting, the keto diet, exogenous ketones, the future of biotech and the development of biomarker tracking devices along with a host of other biohacking topics of discussion.
Learn more about living longer, healthier lives.
 
You can find out more about Geoffrey Woo at https://hvmn.com/team/geoffrey-woo and his supplement line at https://hvmn.com/
 
He is also active on instagram @Geoffreywoo 
You can also subscribe to Geoffreys podcast "HVNM" which Lisa highly recommends.
 
 
We would like to thank our sponsors for this show:
 
 
Makers of Photobiomodulation devices that stimulate the brains mitocondria, the power houses of your brains energy, through infrared light to optimise your brain function.  To get 10% off your order use the code: TAMATI at www.vielight.com
 
 
For more information on Lisa Tamati's programs, books and documentaries please visit www.lisatamati.com 
 
For Lisa's online run training coaching go to
Join hundreds of athletes from all over the world and all levels smashing their running goals while staying healthy in mind and body.
 
Lisa's Epigenetics Testing Program
Get The User Manual For Your Specific Genes
Which foods should you eat, and which ones should you avoid?
When, and how often should you be eating?
What type of exercise does your body respond best to, and when is it best to exercise?
Discover the social interactions that will energize you and uncover your natural gifts and talents.
These are just some of the questions you'll uncover the answers to in the Lisa Tamati Epigenetics Testing Program along with many others.
There's a good reason why epigenetics is being hailed as the "future of personalized health", as it unlocks the user manual you'll wish you'd been born with!  No more guesswork.
The program, developed by an international team of independent doctors, researchers, and technology programmers for over 15 years, uses a powerful epigenetics analysis platform informed by 100% evidenced-based medical research.
The platform uses over 500 algorithms and 10,000 data points per user, to analyze body measurement and lifestyle stress data, that can all be captured from the comfort of your own home
 
For Lisa's Mental Toughness online course visit: 
Develop mental strength, emotional resilience, leadership skills and a never quit mentality -
Helping you to reach your full potential and break free of those limiting beliefs. 
 
For Lisa's free weekly Podcast "Pushing the Limits" subscribe on iTunes or your favorite podcast app or visit the website 
 
 
Transcript of the Podcast: 
 
 
Speaker 1: (00:01)
Welcome to pushing the limits, the show that helps you reach your full potential with your host, Lisa Tamati, brought to you by Lisatamati.com

Speaker 2: (00:12)
Hi Everybody Lisa Tmati here and welcome back to this week's edition of pushing the limits, elevating human performance and helping you optimize your health and sporting performance. This week I have a very interesting man on the show by the name of Geoffrey woo. Now Jeffrey is in San Francisco and Silicon Valley. He was a computer scientist who graduated out of Stanford who then made a startup company that he sold to a public company way back when he was just 23 years old. And then he decided to change tech after having such so much success in that area. He turned his considerable intelligence towards bio hacking and approving and optimizing cognitive performance and now physical performance as well. He has a company now that is called HV him in and he concentrates in the area of keto, the keto diet ketosis ketone esters which is a really interesting area to be involved in.

Speaker 2: (01:20)
He's also very interested in biomarkers and continuous tracking of biomarkers and net technology. And he's really at the cutting edge of what is happening out there in the biohacking world and optimizing performance. So our conversation goes in all sorts of directions. It's a really, really interesting deep dive into what's coming around the corner. What's happening now. We also dive deep into the subject of the keto diet and ketone esters versus keto salts exogenous ketosis versus doing the keto diet it's uses for changing your metabolism and becoming a fed adapted and you know, real deep dive into all those good top topics. So I hope you enjoy the show. And before we get underway, just a reminder, hop on over to our website at lisatamati.com check out our flagship programs. We've got our online run training Academy running hot where you can optimize your running, get faster, get stronger without burnout and injuries and have my 25 years of knowledge to help you get there.

Speaker 2: (02:30)
Along with my business partner, Neil Wagstaff, who's been my coach for over a decade and who absolutely saved my bacon. So check that out. If you want to improve your running, whether you're doing your very first five fiveK or whether you're doing your hundreds 100 miler,uwe can help you. And we also have our epigenetics testing program, which we are super excited about. This is a program that we've been running now for the last two years with our clients and it is absolutely next level and giving you personalized about your health and uhow to optimize your abilities,uinsights that we've never before head. The last program we have is the mindset you, which is our mental toughness and mindset Academy,uwhich is an online course and how to develop all the resilience and mental toughness skulls that we'll see you right in life and help you in all aspects.

Speaker 2: (03:22)
Now I also have my book relentless coming out in March the 11th. It's available now for preorder. This is my third book and it's been one hell of a mission to get it out. So I'm very glad that this baby is nearly born. This is the story of bringing my mum back after her major aneurysm four years ago, and all the protocols, the, the therapies that I use, but most importantly, the mindset and the approach that I talked to this huge, huge challenge of bringing her back from the brink of death. So make sure you head on over to Lisatamati.com Hit the shop button and preorder that now, right over to the show with Jeffrey. Woo.

Speaker 3: (04:01)
Well, how everybody needs to tell me the here now. I am sitting with Jeffrey. Woo Jeffrey. Good morning. How are you?

Speaker 4: (04:09)
Good morning. I know you're dialing from New Zealand and it's still morning in San Francisco, California. So a proper good morning.

Speaker 3: (04:16)
It does, but you are living in the past. So you're a vet. We need something else behind us or anyone else behind us. So I always find that quite weird, but very, very cool that technology allows us to connect Cindy. Now Jeffrey is an amazing man. Oh, you listeners out there who don't know Jeffrey, you assume. Well do. Mmm. He's a, I'd love you to go into a little bit of your background. You're free. You've had an incredible stat life. You were a Stanford computer scientists, but he's gone in a completely different direction, but you've also had a startup company that you've sold on to a public company. I believe ahm what really interested me, I'd love to know a little bit about your background and how the heck you go from computer science to doing what you threw out because that's really a big leap fish, shall we say. Tell us a little bit about yourself. Yeah,

Speaker 4: (05:11)
Thank you for the very kind introduction there. I think it may look like a large leap from a academic perspective, but really the way I think about my career and my, you know, my life's work at this point is really looking at systems thinking and engineering thinking and applying that approach towards different domains. So obviously you can use engineering techniques to look at computing as a way to solve competing problems. And about five, six years ago I started becoming more and more interested in how do you apply some of that same systems thinking that systems training towards the human system. Right. And I think that in one way you can look at health and wellness and the performance medical sports physiology space as obviously quite quantitative. But I wouldn't say that it's relatively bottoms or maybe like tops down in terms of trying to find an approach.

Speaker 4: (06:19)
And I think from an engineering perspective, how do we really develop a first principles approach to really understand the quantitative approach, how to optimize, optimize these, these outcomes. So to me, Mmm, a little bit about like the sort of the personal insurances that I realized that a lot of my smartest friends in Silicon Valley where we're applying their big brains to making robots better, making AI better, essentially. That might be a nice way to put it. But most people in Silicon Valley are helping people click, right? Like they are essentially optimizing and targeting people based on their previous experiences. How do I drive traffic and $5 and I was in that industry. And how to mobile app companies so that coming into Groupon, Mmm. And that gave me a little bit of a perhaps a luxury to just think about what I really want to think about and work on. And I thought that human performance was just the next frontier. And that got me down the rabbit hole of being very plugged into the biohacking community. So very much self experimenting and learning just glucose ladders but measures two now starting and running a company called HVM N which stands for health BMR nutrition. Where are we create products and technologies that support a human performance. And you probably have heard of our ketone Ester drink, which a very interesting piece of technology.

Speaker 3: (07:45)
Yeah, I was really excited to hear about that and we'll get into that later because you are a very big expert on ketosis and Keto and everything. Can you tell me basically and I just found it really fascinating. Was there a personal health process or someone in the family or anything that you decided you wanted to go into the spice? So it was just purely I want to optimize my moments in the performance of people. In general.

Speaker 4: (08:10)
Yeah. Actually the ladder. And I know that many people in the community of what I've talked to, literally thousands of people in the broader community. I feel like most people make very drastic life changes when there is a crisis. There's a health, and I have to admit, I was just fortunately in a very different space where I was just healthy and I was wondering can I even be any better? So is very much very focused on the optimization perspective. But now in retrospect, I think it's very much the same problem. Yeah. We're all on the spectrum of being sick or being a deficient state and we all want to move into other directions to be better. And our starting location on this section can be a little bit different, right? We can some healthier than others. Some are more deficient than others, but we all want to move in that same factor of being better.

Speaker 4: (09:01)
Mmm. So to me, my initial interests started off in cognitive performance. And now it's just essentially based on this notion that humanity has become more and more focused on cognitive output as a way to create our likelihood. It's whereas 2000 years ago our physical output was our primary mode to play to Libby. And my interest there was that especially in this new economy, there's a very much interesting sort of winner take all dynamic. If you can pick out a few more percent of cognitive performance kid creativity that has a disproportionate leverage in terms of the outcome that you get well economically as well as amongst competition. So my initial interest was focused on cognitive performance and as I started more and more new tropics, Mmm. It became kind of this rabbit hole diving deeply into metabolism. Mmm. The entry point of nootropics led to fasting and I was, I would say one of the, you know, early are people on the wave of fasting about four or five years ago or started experiment fasting.

Speaker 4: (10:17)
And then that really became a trend in Silicon Valley in the larger work. Now, intermittent fasting is like a very common parlance term that of people talk about. It was very interesting that you know, four or five years ago, if you Google fast people that I live in, maybe not drastically, but it was just like, Oh, [inaudible] for few days, that seems kind of insane. Is that even possible? Intermittent fasting led to kitchen diets and w it was became like, because as you look at the mechanism of why fasting works, fasting basically the pleats are glycogen into glucose reserves and it forces your body to convert fat into ketosis in the kitchen. That was a very interesting way to also in Dutch produce ketosis. And there was a very interesting, again, relatively early in the phase of I would say the influx of publication research going on in the QJ today at the time, you know, more of a nascent field.

Speaker 4: (11:22)
And then as I'm looking at the ketogenic diet, like, I mean, interested in things like ketone masters or any of the other enzymes just keeps on how can you [inaudible] induce a very rapid details ketosis in some sense. It was just like a very crazy journey from being a Stanford computer scientist and a software entrepreneur to now being the human performance space. But if you just look at the five, six year journey of looking at the problems of that I was interested in, and then just pursuing and digging and researching and going deeper and deeper down the rabbit hole, it kind of all makes sense in retrospect. And I think that's kind of the fun journey of life. I don't know if you thought that you would have a podcast five years ago. Right. And just like, same with me, I didn't know no conversations with people around the world about health, you know, world champion athletes. But that's really, you know, when I have a bit of time to reflect and just really the beauty of life, enjoy the journey.

Speaker 3: (12:20)
Oh absolutely. And I think, I mean I'm the same. I've gone from being an athlete to now, you know, specializing in brain rehabilitation and writing books and doing podcasts. And I don't think we should limit ourselves to, because we learned something at university or at school and it set for us for life. I think that's the beauty of the time that we live on that we can go like this for richer, you know experience, you know, and, and and you bring a completely different lanes too. The health side of it. That, and I don't have, you know, that you're [inaudible] amazing brain that you've bought too, you know, from being in computer science and then applying that sort of modeling [inaudible] to the human body. And and I've heard a few people obviously along these lines site. There's so much similarities and I think there are, it's exciting to think of it in that, in that way.

Speaker 3: (13:16)
So you go into the ketosis in the, in the keto diet because this is that's something that's very, very interesting for many of my lessons for sure. So I come from, you know, an extreme endurance background where you're doing like mega long races. And when I started out, it was all you had to be having calories and carbs all the time. And you know, the high points of my career are you eating up to 10,000 calories a day? Two, yeah. Move, got fuel yourself. And if you didn't get those calories and you've hit the wall and now, you know, there were quite a few Phanatic for the athletes. What's your take on, you know, like with extreme endurance, like doing ultra marathons and so on? What are the, what are those bandages and disadvantages that you would say? I mean, I know that you, you've done a half marathon yourself or, or a couple I think. Yup. You get Running sort of analogy. What is your take on, on, okay. The use of oxygen per year per unit. I, I, and the stain is much, much higher when you're on keto, but I've never actually tried it when I was competing. So I'm really interested to see what you want. Well, it's our own map.

Speaker 4: (14:29)
Yeah. I think it's nuance and I would say I don't think it needs to be overly complicated. So the way I think about it is that there's perhaps I would say two categories of athletes. There's, I would say the category athletes are looking to the world championship caliber level and looking to optimize performance perhaps at the detriment of longevity and lifespan and health. And there's a second category of athletes that are more lifestyle. They want to, let me just, let me just put, excuse me. Yeah. And the second category of athletes that are more lifestyle and amateur, right? So I think even at that level there's different recommendations and I would even slice up the categorization in another way. There are training periods and the competition periods. Right? And I think for endurance athletes, that's, and again, athletes are more serious. That's like a very, it's a known a practice, right? You guys are training your psych, your training towards, no, even with that there's like literally before different subsets of talking about the same thing. Right. And I think within the broader common discussion, it's very easy to say, Oh, you should have carbo. And it's like, well, are you voting for training? Are you trying to win the marathon? Are you trying to like have a good day?

Speaker 4: (16:04)
I think simplification, you already missed my little subtleties in those four quadrants that we already subsets segmenting out. Mmm. And then if we just know specifically for ultra endurance or highly anaerobic activities that is a very different performance profile or it's power lifting, etc. Yeah. Mmm. So a traditional best practices is the assumption of art, bloating and there is good reason why one wants to have a lot of carbohydrate reserves and then you constantly supplement sugar or gurus or, yeah. Let me think as you, as you compete. Mmm. Now the ketogenic diets and being more fat adapted is becoming theoretically and the research perspective has always been interesting and I think within the last few years there are now a world champion ship world record breaking results that are being created using fat adapted athletes. Again, there's like the randomized controlled trial world which are done on serious athletes, not necessarily like you are the best person in the world, right?

Speaker 4: (17:17)
Like there's a difference there and Zach bitter is an interesting case study of work. He just recently the world record for the a hundred mile Ryan, very, very ultra endurance. I think he also broke the world record for the 24 hour distance cupboard and Mmm. The whole notion [inaudible] and he's a sort of a fat adapted athlete. So what, what so, so I think like, so even so, so the basically would say that the study research is based on serious athletes and there is good results or decent evidence that being fully keto adapted is comparable to being a carb driven athlete. Now the question is if you want a world record and performing performance, how would you protocol against that? And if you actually talked to Zach better, he will take carbs for the actual performance. But in the training blocks you will train fat, adaptive or fasted. That's an interesting subtlety that I don't think it's covered really well. So when we talk to athletes and when we work with athletes people really understand that you guys, your training blocks your physical activity alters over time. And I think what will be the emerging trend is that you will cycle, you knew your nutrition along with the training blocks to optimize the peak for a certain performance. I think that is implement at the very, very top levels and I think that will be translate at two lower. Yeah.

Speaker 3: (18:58)
The next one very interesting point. That cyclical nature of ketosis or you know, I like to be in ketosis constantly can be, can present its own issues. Context.

Speaker 4: (19:08)
Okay. Yeah. I mean there's no reason to think that it is necessarily bad, but there has been an interesting research coming out of the buck Institute showing that a cyclical ketogenic diet has similar health span impact then on permanent kitchen and dining on an animal, on a mouse model and a rat or rodent model. So this is really, I was at the cusp of cutting edge science. I think some of these answers are still going to be unpacked. And I think just from a public perspective, if I were to Kim like guidance and I just want to make it like a punchy resolution. So like just kind of like just mentioned one of the nuances that if I were looking at endurance performance, I would consider doing fat adapted training fasted or using fat as a fuel in early parts of my aerobic training block.

Speaker 4: (20:07)
And then as you get closer and closer to performance day, I will start reintroducing carbohydrate and then on performance day I would have a blend of both. Like he's like exotic, just keep telling me like ketone Ester and on race day itself. So basically on race that you want to fuel as much substrate as possible and in the preparation to that performance day, you train and maximize the metabolic flexibility of your body. You want your ketone metabolism to be high, you want your fat oxidation to be high and you also want to be able to use carbohydrates.

Speaker 3: (20:41)
Okay, so you need a ball flexibility. Can you explain to the listeners a little bit, what is that like so how hard is it become fat adapted and what is the power with your ketone? Is that your company producers compete to an MCT oil Im sorry as a two part question, but or you know, your normal sort of exogenous ketosis, you know, compete to the level of the ketone ISTA yeah, yeah,

Speaker 4: (21:09)
Yeah. So I'll answer the first part around metabolic flexibly. I think that's definitely one of the buzz words being thrown around in the community at this point. And it's really a simple concept in the sense that it's your body's ability to metabolize, which means like use as energy the different macronutrients or substrates that exist. So what are, what are macronutrients? There's simply just food stuffs that have calories, right? Like carbs have some calorie count that has some calorie value and putting out some calorie value. Something like or caffeine there like micronutrients. They don't have calorie sources, but they support metabolism or, you know, caffeine is not really my patients. It's, you know, blocks and things that you feel less tired. Right. But it's like, you know, people talk about that as like an energy. It's not necessarily an actual calorie substance. It's just like, yeah. Tricks your brain into feeling less tired.

Speaker 3: (22:06)
Yeah.

Speaker 4: (22:07)
Mmm.

Speaker 4: (22:08)
So what is it about flexibility? Well, when, especially in a standard Western diet context, we eat a lot of carbs. So that essentially trains your body to be really good at carbs as a feel substrate. So all the enzymes that relate to glucose metabolism are upregulated and your body isn't really using the metabolic pathways to process fat or ketosis. And it's dotted. Those pathways are done regulated. So if you actually look at like fat oxidation Bates, you can actually measure this in people. Mmm. People that are less metabolically flexible will burn less fat as thesis versus someone that is more math, metabolically flexible.

Speaker 3: (22:54)
Wow. Another reason too, you know, trial, the cycling that links into ketosis,

Speaker 4: (23:00)
Right? So you can, you know, so you can do what's called like respiratory quotient test, so you can breathe. Mmm. You know, you breathe in and out and then you measure the ratio of CO2 and OTU as you ramp up intensity. And people that are quite metabolically efficient can inflect quite fit and burn fat to a very, very high level. Whereas people that are less Mmm. Metabolically flexible and not very fit, they instantly turn into using anaerobic or glucose as energy as opposed to being able to use that. Yeah. So so when we say metabolic flexibility, it's the ability for your body to use and burn all these substrates at the same time. Mmm. And and I think I think that touches upon like so much other sort of cascading into like in talk about insulin resistance. Yeah. It's really just touches this whole span of how metabolism works. I think just in the cons of this specific topic, it's just essentially the notion that you can switch fuel sources relatively efficiently.

Speaker 3: (24:11)
So if, if you know, I'm going to go on a keto diet, a lot of people have, you know, the keto flu and then they give up because it's pretty hard. Horrible. Mmm Hmm. Does something like keto Ester that the product you have or even exogenous ketosis of any form speed you up to get you into ketosis? And does it help you avoid the KIDO flow or not?

Speaker 4: (24:34)
Yeah, so this is actually a good bridge. I didn't answer your question. It's like what is the difference between other and goddess ketosis? I think that's like a nice segue or transition. So when people go through the keto flu, that's essentially a sign of metabolic flexibility. So why is that? Well, when you suddenly cut off your carbohydrates, again, your body is used to using carbohydrates as a fuel substrate. So when your body runs out of carbs, it's like it's in an energy deficit. It's like, Oh, I'm really hungry. Like we're not getting enough fuel. What's happening there is that your body isn't as efficient at converting fats and oxides and fat and mobilizing fat and mobilizing and turning that find the ketosis. So there's this deficit period for it. You have low carbohydrate, low glucose,

Speaker 3: (25:24)
Okay,

Speaker 4: (25:25)
Any of low ketosis at the same time, you have low energy substrate available in your system so you feel tight. Thank you. Mmm. So the idea is if you are metabolically flexible, so like you know, I've done a lot of fascinate. I eat fairly low carb and I'll do cyclical blocks of Hito aye can generate ketosis relatively quickly, so I don't really get it. Yeah, I like the adaptation for period for me it's like quite quick. And now the question is, can you use exotic as ketosis to help bridge that energy gap? Well, essentially that's been one of the popular use cases of his audience. Ketosis, right? Mmm. I would say the nuances that it doesn't increase the ability for your body to produce its own ketones. Actually nice gap where you have low glucose, your body is still trying to ramp up ketone production.

Speaker 4: (26:27)
Let me just give you some support of having like a source of energy. It's not carbohydrate in the interim that makes that transition period a little bit smoother. That would be the application of massages. ketosis. Now let's answer the initial question. What are ketosis? What are the types? What's interesting about ketone Ester? Mmm, let's define what ketosis are in the first place. Well, ketosis or what I consider a fourth micronutrient interesting thesis there is that, well, you have fat putting carbohydrate. They have calories and their metabolic substrate, well, ketosis have the same exact both fallen, they match the definition, it has calories and it is a fuel for metabolism. Mmm. But you can't really, it's not fun and really in huddle, almost a normal food. So people have been trying to synthesize Exxon, just ketosis that you can consume each directly. So you can kind of really get new food group here.

Speaker 4: (27:32)
You actually MCT oils, what are they? MCT, medium chain triglycerides are fatty acids that readily convert into ketosis. So the fact, but it's a relatively efficient fat that converts into through your liver, through ketogenesis into ketosis. Caprylic acid or ch is the most efficient a fatty acids that converts that into beta. Hydroxybutyrate. you can, it's eight carbon eight carbon linked chain. And then if you look at PHP, it's four carbon. So it's like a very nice size fatty acid that readily converts with a pH. D ahm so what does the HV well, what does ketosis will? He, one's a scribe. This fourth macronutrient and the main form of a key talent is this specific molecule called BHB or beta hydroxybutyrate. I just think they may be HP. So it's not quite a mouthful. Mmm. Now if you can take a BHB is the end ketone that you want, can you deliver that in the food form?

Speaker 4: (28:40)
And that's where you have things like you don't ask sitters or ketone salts that you might've seen. So these are just different formulations or different ways that liver beta hydroxy be [inaudible] in a consumable form. The very cool thing about ketone esters, however, is that it's a very highly efficient way to deliver a lot of ketones without any GI issues typically associate with ketones salts. So if you actually look at, Mmm. The space, I would say like, there's like things like MCT oils. Okay. You know, that has its place. It's valuable, right? It's like a nice form of fat that can refer in the ketones, but it's not an, it's just keep telling, right. It's not eating beta hydroxybutyrate directly. And then we look at Exondys ketones. There's primarily, he don't insults and then ketone esters. And what he consults are essentially hydroxybutyrate bound to minerals like sodium, potassium. I'll see the, so we oftentimes

Speaker 5: (29:42)
You look at a label of a ketone salt, it's like a ton of minerals. It's like a hundred percent of your life recommend daily allowance salt. Yeah. Small drink. You know, so you know, there's arguments whether it, you know, people need more salt anyways, I think that's a different rabbit hole. But regardless, I think from a performance perspective, there's often GI issues. We have so much salts and that is a real concern from a performance perspective. A ketone esters its bound to ketone precursors. So it's just a lot more sure way to deliver ketones and yeah, without the salts [inaudible] I can imagine if you've got a lot of salts and minerals and the ketone salt as an athlete, for example. Good. Cool. It's traveling and endurance. Yeah. example Okay. Okay. So that's that six dodginess keto. And so can you tie, so the one that you have at your company that's been developed over like I think 20 years from a time of all the basement money going into this, that the race H money is this much more powerful than, so, you know, just for the lay person then then buying an MCT oil, it's your rate pay times rather than a precarious or or having to go through the liver to be turn that into hopefully ketones.

Speaker 5: (31:13)
Yes. Yeah. So yeah, this is measurable and you can like do this like with your own finger and if you actually measure ketones, do a finger stick, typically like an MCT oil will bump your beta hydroxy Peter your D levels to maybe 0.5 bump. And with the [inaudible] or we can, you'll typically see up to 5.0 millimoles. So literally 10 times wow. More ketones delivered. That's in a consumable form. Mmm. Does that negate the need to be on a keto diet when you have ketosis? Can you get away with eating carbs? That would be the optimal. Yeah. So that's like an interesting area of discussion. And research some people. So some would say yes, I think it's nuance. So basically it's like what do you want on a kitchen? I think there is some value of carbohydrate restriction, carbohydrate restriction, but a lot of the benefits of a kitchen dining is having ketones present to be metabolized both as a metabolic substrate and as well as a signaling molecule. [inaudible]. So the question is how much of the benefit of a kid doing diet is from the carbohydrate restriction alone and how much of a benefit is from the ketones and both of substrate and a signaling molecule. And that's really an area of research.

Speaker 4: (32:40)
My you know none I have no data to support either direction. Is that Mmm. There's some subset of the value that's delivered by fastener kitchen guys that comes to record themselves. Yeah. So can you get some, most of the benefit of a kitchen guide or facet? It's not just ketone. I think so.

Speaker 3: (33:05)
That would be the.

Speaker 3: (33:07)
So that will be interesting to see how that research unfolds in the next year. You were telling me right. That would be, you know, cause obviously the keto diet is quite a difficult diet for many people to adhere to. Especially the all team. And what about the whole triglycerides problem? When people are on a keto diet, what's your take on, on the negative sides of, of keto?

Speaker 4: (33:33)
Mmm, usually you, yeah, so the lipid like the basically is your blood lipid panels is something that people tend to look at when you're looking at, you know, high fat diets, right. So you know, people look at triglycerides as you mentioned, but also LDL, low density lipoprotein cholesterol and HDL high density. Mmm. So the typical concern is that if you eat such a high fat diet and audio thats well lot and that could be a reasonable concern. So there's some interesting data that that perhaps suggests that if you look at LDL alone, it's not really a great predictor of cardiovascular disease risk. You should really look at the trial of LDL, HDL, triglycerides all together. So typically in a well formulated huge diet, you may see an elevation of LDL, but you see high HDL have low triglycerides. And then the question is, and again, I don't want to be giving medical advice, I'm not a medical doctor, but there is an interesting stream of research going on now where if you look at a cohort of people with high LDL, which maybe bad, you know, high HDL and low triglycerides the association with cardiovascular disease risk disappears.

Speaker 3: (34:58)
Yup.

Speaker 4: (35:00)
The question is then, is LDL alone a great predictor of cardiovascular disease risks? I think that's again, an open area of research. I think again, just again from a systems thinking perspective you need to look at the whole system. It's kind of arbitrary to just choose one thing and be like, okay, you have one thing that's going to give you a disease. So it's like, yes, that might be correlated but me to understand the full system. Yep. And that's where I think there's a lot of interesting research.

Speaker 3: (35:32)
Yeah. And it would make sense to me that, you know, you do need to look at the ratios of things. Like I, it's, it's looking at

Speaker 5: (35:38)
The whole system of things and you know the old way of thinking that cholesterol was bad for you, period as, as really not, not correct. I think, you know, now we've moved on from that sort of idea that that isn't the way. Yeah. They just like complicated and like very nuanced I think. I think people want that headline. I mean, how many times have you seen eggs are good? Yeah. It seems like it's literally like it flip flops every single day. Yes. And I think that just shows you that nutrition is very complicated. People have different genetic baselines. People respond to food differently. Yes. Yeah. To me, I don't want to be overly prescriptive on everyone should eat like, again for me, engineer and meet us. Okay. Like self-experimentation you should really measure the response is yourself. When I see my own glucose numbers and I see my own blood lipid profile, when I do these different types of diets, I know what works for me. Supply. And that ultimately is what matters. Like it doesn't matter what the randomized controlled trial says for a population of like men that are age 25 through 30 in a U S college, the people that are being studied, right? Like there's a reasonable critique on the selection sample [inaudible] what all the science is done on, right? Most clinical trials are not unwomen no, no. Well done.

Speaker 5: (37:16)
Okay. It's really hard to run science. I understand why people want to like reduce the very variables. I think it's like [inaudible] the, again, the mechanisms that you can derive from the literature and then confirm it with yourself. That's ultimately, I think the general literature. And then how does it actually apply to you as N equals one. And this is, this guy's nice segue into your stance as an advocate for smart regulation, for human enhancements and in our ability to take control of our own. You know, like a lot of biohackers now around the planet. And I include myself in this, that we believe that we have the right to control their own bodies and we, Oh, I'm not prepared to give up my control what I have in my own house. [inaudible] The local doctor. [inaudible] No, and I think it's, it's important that we start to take some responsibility because we've also had, you know, in our culture, in an SSO, I'd say the opinion, the doctor knows everything and I don't have it.

Speaker 5: (38:26)
Right. Question to experiments to understand. And you know, I, I mentioned to you before the journey I've been on with my mum and I've, you know, peer shape. Did we say from those experiences, I, I now want to be [inaudible] in control as I possibly can be. Obviously I don't have access to everything. I would love to have access to. Mmm. But I want to, I want to have the right to be able to try things on my own body and to be able to experiment and to understand, set people, understand that it's the responsibility, their own health into their own to do your own research. We live in a time that we differ with we, we've got access to two minds like yours and experiences like yours and the cutting edge science and the latest, we don't have the sizzle one person's opinion from a local who tried to 25 years ago. Yeah. [inaudible]

Speaker 5: (39:37)
Aye. 100% agree with everything you just stated there. I think you put it quite nicely. But do you want to just, I guess make Cognits I don't think healthcare system or the specific, the individual clinician is the enemy that they're trying to do their best. And those are, I would say like, I don't think anyone is excited about the healthcare system. Well, I think the underlying point. And so I think I've talked a lot of doctors and I think there's, I think everyone is trying to do their best. I don't think anyone is individually. No, but I think the point that it really is an underlying point is that people should be self-empowered take agency of their own health and happiness. I think that's a really the most important point because you care about your own health more than anyone else. Yeah. I mean it's just like, yeah, you're a doctor like cares about you, but he has his own problem.

Speaker 5: (40:38)
She might have a, you know, family issues with her husband and a hundred other patients to worry about. Yeah, that's fine. But you, you are living with your body. You are living with your own health and just like you wouldn't absolutely do business deal or buy a house or buy a car without research. How, why would you not take that same level of research? Important medical procedures or lifestyle choices, spiritual and health. So to me it's just not even like challenging that healthcare system. Just like hello. You care about your health the most. You have the biggest stake in your own health. Yeah. Oftentimes we're just asked to just be passive in our own health. And that seems so backwards given that you spent like 20 hours online searching the latest launch of a computer and gadget. Yeah. Change your change or nutrition change, take medication and you're just like, Mmm.

Speaker 5: (41:38)
Hiking up. Yeah. Just pass it again, I think, and I think basically my sense of the future is that information is being more and more decentralized. I think successful doctors will have a much more collaborative relationship. Mmm. And ultimately we are the buyer. We are the customer in this relationship. I think there will be a world where it becomes much more collaborative. Like these are my specific concerns. Can you address, these are my goals, this my science position. I want to understand and take a little bit of a self-responsibility here. Rather than do annual checkup, he'd see me for 15 minutes and I'm on my way with a couple little pills. Right? Like I don't think that's going to work anymore. No, it can't work anymore.

Speaker 5: (42:33)
Well, you're also on the cutting edge. You're in Silicon Valley. You see a lot of the biotech stuff that's coming in the future. I listened to a speech that you did on [inaudible] the feature of five tickets and where you see this going, expanding Cuban capabilities. And I was just like, wow, really? Mmm. [inaudible] What is coming down the road? Can you give us a little bit of a sense of what you think is coming as far as what and the size? What else? Yeah, it does some exciting and some scary things in the future. Yeah, I think my framework here is that again, just sort of the engineering hat on. If you can't measure it, you can't optimize it. I think that we will get much more are available biomarker data on our overall system. So I think as I mentioned, if you have a continuous glucose monitor, no, there is a very nice device too.

Speaker 5: (43:38)
Again, track your blood sugar continuously over time. No, I know there's, you know, I love to attract much more biomarkers, right? I need a big companies looking at it, looking at the space. So I think phase one or step one is that we'll have Oh, passive data stream across all the important ball markers readily at our fingertips. Like what could you have, not just a continuous glucose level? Well, why not have continuous ketone levels but not have confused insulin levels? Want to track your LDL HDL and triglycerides over time. I think this is one thing, you know, with a strong quantitative mathematics background, I think biology is the built on snapshots, one blue draw, and that's what we base everything on. But we're literally dynamic systems with flux with flow.

Speaker 4: (44:32)
These things change a lot. And I think

Speaker 3: (44:36)
[Inaudible]

Speaker 4: (44:36)
Literally, if I eat a ton of fat that day before a blood draw or I fast the day before a blood trail,

Speaker 3: (44:44)
Yeah, you've got to be completely different.

Speaker 4: (44:47)
We need to understand the actual flux and slopes of all these changes rather than just like do science on snapshots. Right? So I think it's like physics. It's like you're taking, you're doing physics with looking at a planet move every year versus, okay, what if we can attract telescopes, the movement of the plants, we can actually model this much better. So I think from step one, like we're going to have much more available real street, real time streams of data. Mmm. I think once we have that real time passive data stream, we'll be able to have a much more personalized recommendations and protocols for people.

Speaker 3: (45:26)
Mmm. I think we all do. We notice. Yeah. Yep.

Speaker 4: (45:30)
I like you like certain things differently than other people and you respond to things differently. Other people, there was a big metabolism paper publish it. Probably not true three years ago. Banana to me, my response. But you might be able to tolerate it. Yeah. And it totally makes sense, right? If like my ancestors ate bananas and your answer says made apples, like there's going to be an verbalize world and we're just eating a bunch of like fake bananas and fig apples. It sends a reason. It will have different responses to that kind of input. Mmm. So, given that we have the data streams, we can actually now and build time instantly adjust our diet or nutrition or protocol or exercise or sleep to match actually.

Speaker 3: (46:18)
Okay. Is optimal for our four ad thing. Yeah. I mean we, we do an ad company AP genetic testing and we look at the genetics. Yeah. Mike half of people and have the personalized recommendations. Oh. Based on the work of a Dr. Albert, you're rolling from Italy. I'm looking at for being different on different science disciplines and distilling it into some Mmm. Reports that we can take and then have an insight as coaches and as health coaches to be able to personalize to, to at agree at this stage. It'll get better and better as time goes on. What times of the day, you know, you chronobiology what your genetic, your ancestry is to how you going to, how you develop them in the womb, you know. Mmm. And there are all these different layers that is giving us as coaches an insight into our athletes and our clients that we knew made before forehead. And this is only going to grow, you know, and I'm excited about that. Firstly is that is a coach because we're seeing much better results now. Yeah. You know, you're trying to, two athletes are the same. No, I had in the same training and one will get massive

Speaker 5: (47:30)
Results and the other one doesn't. And you're like, why you lying to us? You're not doing the stuff, you know, that's actually, no, they just, I'm really excited about all the tracking stuff. I'd love to get a constant glucose monitor. I think you're exactly right. I feel like oftentimes we talk to doctors, they'd like don't believe their patients. Yes. Like literally trying to pull up. That's right. Establish the doctor patient relationship a little bit. I mean, again, it's not to say doctors are not trying to do their best. I think it's like, I would say I would say let's just empower ourselves and learn more so we can have a productive conversation with primary practitioner. And then they're just like, kind of like, you know, I see coming around the corner is that like, you'll have more and more interesting technologies that are drive inputs into human performance.

Speaker 5: (48:35)
She don't ask her other, other exonerees ketones are very interesting. It's a new way to deliver soap fit into our bodies and signal different things. Mmm. Interesting. Compounds tap into longevity pathways. Right? And I think we're understanding the systems biology of humans much, much better. No, it gives us an ability to, maybe we can push certain inputs in a way that maps to a performance profile that we want. And again, like, and that can be different for different people, right? Like maybe if I'm obsessed with health span, I could be different from, I want to win an Olympic gold medal next year. Definitely coming from an F, you know, lytic background where, you know, push my mind to the limits. It wasn't about longevity at that stage, you know you can do a lot of damages and ask that you can be fit and unhealthy.

Speaker 5: (49:32)
Which is which is also a [inaudible]. But if you're an athlete, you've got to be healthy. Well, actually, no, you can be quite unhealthy, but yeah. And now as an, you know, getting, getting older and getting a little bit wiser and looking at longevity and wanting to have health span over a longer period of time, I've changed my whole approach to the way I try and in the way. And I think that that's a healthy progression too, to move in. So you said that, know I'm looking at being able to do what I want to at 19. Oh, I've [inaudible] 105 I believe. Yeah. Be completely broken and burnt out. Yeah. Which I've down in the past and which I see a lot of athletes [inaudible] okay. And, and having this information provides, gosh, when I started doing ultra marathons 25 something years ago, we didn't even about electrolytes for crying out loud, you know.

Speaker 5: (50:30)
And, and now of course, we bought whole lot more things at our fingertips and we can, we can see the improvements in performance over the last few years with extreme endurance athletes. Like, thanks. Mmm. It's only gonna [inaudible] yeah. The limits of human performance aren't even breached. Yes. You know, and that's without tapping into the whole mind side of it. Yeah. Oh, so another fascinating side. Mmm. I just wanted to pivot and then I know we're going to wrap up, but Mmm. You've also gone a pretty deep dive into Nutro nootropics. Hi Brian. Enhancing supplements in a smart drugs and things like that. Having some of the family with a massive brain, Brian and Dre, I'm very interested, eight year old take on what some of the great nootropics for people who Mmm. Maybe him brain injuries, maybe hitting towards dementia, Alzheimer's that sort of thing.

Speaker 5: (51:30)
I know you're not a medical doctor, but what is your title and some of the exciting compounds or even the ketones for, for things like to meet turnouts farmers. What is your take on that? Yeah, I think it's a very based in the sense that there's a lot of things that are preferred to have any Tropin benefits, but you really need to look and drill down into specific compounds and then judge the evidence of each specific compound on your specific use case. Right. So you know, when we developed our nootropic supplements, we looked at specific compounds that have randomized controlled trials on healthy humans and showing no benefits cause it's going to get benefit for those use cases. But oftentimes things that can improve on performance in healthy human, this monkeys are an improved performance. People that are efficient. So when you extend the scope a little bit evidence pool, it gets a little bit even better.

Speaker 5: (52:34)
And when you're looking at eventually, hopefully hoping people that have my own cognitive impairment and trying to prevent decline and move that more towards awesome. The direction. So obviously, you know, you know, the products that we sell, you know, we think are very, very high quality and how the robust evidence, so we have rise with the Copa which has, you know, solid book amount of evidence around randomized controlled trials on specific doses, boosting longterm memory, et cetera. So that's pretty exciting. If you actually talk to the principal investigator who's actually a professor concert, I believe he's at the university of Swinburne. No excited about that class of compounds and I believe it's still do not research in that area. Mmm. No, I think ketones are also like an interesting area of research in terms of driving cognitive a benefit. Mmm. The mechanism of action there is that glucose costs the blood brain barrier, but also the ketones.

Speaker 5: (53:43)
And you might've heard of Alzheimer's nickname type three diabetes. Yeah. And the thesis there is that part of the problem with Alzheimer's is that there's a glucose uptake disfunction where it's for whatever reason, well, it's insulin resistance efficiency. All right. The brain cells aren't able to process glucose. Well, ketones are uptake and metabolism, a completely different pathway. Can you rescued energy deficit that, that defect substrate. So it's been pretty early data around ketogenic diets being helpful as well as exotic as being helpful for those use cases as well. So I just had a Dr. Kabran Chapek on the show last week. He's written about concussion rescue. You're looking at a traumatic brain injury, Al Thomas. And there's a, when you have a brain injury for example, there's a metabolic no problem. What's that glucose getting in it? Where The good coach is not getting put in.

Speaker 5: (54:53)
And they did a at trial where they put and IB glucose and people with brain injuries and they suppressed the ketones. The body was producing this morning. It was actually feeding the brain and actually made them work. Yeah. And this is like, Oh my God, that's what they did. My mum when she was in ICU, they put in, you know, and I'm like, I had no idea at the time glucose was not, it would be logical to think cause you Brian needs you a lot of glucose. Well, when there's a metabolic disruption caused by the brain injury, it would have been far better to give her pay times and, and you know, ketone Ester or something or even fish oils so on to feed the brain then then glucose and suppressing what little ketones you would have had, you know. No, that's exactly right.

Speaker 5: (55:42)
The mechanism that you're describing is exactly right. This kind of Columbian released a blood glucose uptake. Yes. Yeah. It's again, that's where you have to understand the mechanisms too. Have a solution. Yeah. Again, I don't want to like, I think, you know, we don't want to over-hype anything. I think that's another area of interesting research. I think it's an interesting and hopefully we'll be able to see published results. Yeah. From that hypothesis. That's exactly right. You know, the mechanism of action we would be targeting looking ketones or concussion and TBI. That's absolutely, yeah. Yeah, definitely. You should click with or listen to my last episode cause that was a really, you he'd be great to get on your show. So I know we have to wrap up. You Mmm. Some of your products, you've got your new tropics, you've got your, the one, you've got a sleep aid, you've got a focus, memory aid the other two, you hit another two there.

Speaker 5: (56:51)
Omega-3 DHA focused like a brain DHA supplements called keto. And then we have chronic longterm cognitive performance will rise. And then we have sprint, which is but cute a caffeine off. He needs that. All right. So if anyone wants to check them out. So you have a podcast. Yeah, the ice, we mean podcasts. So everybody go and check out different words on the podcast. HB in him. Yep. I always get the name. I must be slightly dyslexic around their own way. When people reach out to you and connect with you and the work that you doing. Mmm. Can I get the ketone esters by your website? So I understand you're out of stock at the moment. Yeah, I was checking on the website and that will be the most up to date place to get updates at hvmn.com. Yeah, it's always interesting in the beginning of the year because a lot of the institutional sports teams kind of stock up for the season so I can add on the shelves. Yes.

Speaker 5: (58:04)
You know, it's sort of like first come first serve, right. It's, you know, I guess there's been a lot of media coverage on tour de France teams for example, using our product. So that's coming up later this summer. Right. Awesome. A lot of the salient volume goes, goes there. Yeah. I mean you find us on each PMN very easily searchable, but also personally at Geoffrey Woo, G E O F F R E R Y W O O primarily on Twitter and Instagram. Happy to engage there as well. Awesome. I will put all those links Geoffrey in the, in the show notes and thank you so much. We appreciate your time today. I really appreciate the work you're doing. I love listening to your podcast. I, I do feel at the end of it quite challenged intellectually often. But it's at the cutting edge of what's happening out there. So it's really, really exciting. So thanks very much for your time today. I really much enjoyed the conversation. It's super fun. Thanks for having me.

Speaker 6: (59:05)
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Speaker 1: (59:55)
That's it this week for pushing the limits. Be sure to write, review, and share with your friends and head over and visit Lisa and her team at lisatamati.com.
 
The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional.
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