In this episode, Alan Cash talks about oxaloacetate and the beginning of his journey in developing it as a nutritional supplement. He shares the ongoing research on oxaloacetate's benefits, especially for patients suffering from brain damage. He also dives into oxaloacetate's ability to increase muscle use before fatigue and reduce anxiety and depression levels in women experiencing PMS.
If you want to learn more about oxaloacetate's many benefits and applications, then this episode is for you!
Alan got sick and needed to undergo brain surgery. He found out that his pain and illness were related to ageing.
As Alan researched more about ageing, he discovered calorie restriction, wherein organisms tend to live longer when they eat less.
Increasing the ratio of Nicotinamide Adenine Dinucleotide (NAD) to NADH helps fight off ageing.
Alan started looking into biomechanical pathways and found that oxaloacetate that can change the ratio of NAD from NADH to 900% in just two minutes. He started testing oxaloacetate using worms and realised that the activated pathway was the same as calorie restriction.
Oxaloacetate is a naturally occurring molecule in our bodies during metabolism. It exists in every cell of the body and, therefore, is non-toxic.
Oxaloacetate is considered a hot molecule right now, given how it can help moderate metabolism on a cell-by-cell basis. Increasing oxaloacetate affects metabolism, which is vital to some people.
Tohoku University in Sendai, Japan, conducted research in the 1960s which found how oxaloacetate reduced fasting glucose levels in type one and type two diabetics.
At first, Alan ran into the problem of being unable to get a patent for oxaloacetate, a naturally occurring compound in the human body. He persevered and eventually was able to own patent rights based on how oxaloacetate can maintain its stable form of enol-oxaloacetate.
After rigorous testing, their products now have a shelf life of two to three years or more.
Oxaloacetate is a potential drug for brain cancer such as glioblastoma. It also has the potential to reverse the Warburg effect, in which fermented glucose turns into lactate that a tumour feeds off.
Giving Oxaloacetate to cancer cells changes the cancer metabolism cell by cell. There’s a specific dosage where cancer cells stop reproducing.
Glutamate is a compound that fires off the neutrons in the brain. Excessive glutamate excites the neurons until they die, a process known as excitotoxicity. Many studies describe how we may reduce the risk of excitotoxicity.
Alan is looking into cognition through clinical trials with Alzheimer’s disease patients. The study showed how oxaloacetate reduced glutamate levels. In the same clinical trial, they also found how oxaloacetate increased the amount of glucose the brain can take in.
The brain can take in more glucose due to the signalling protein PGC-1 Alpha enabling the production of more mitochondria.
Oxaloacetate also improves muscle use by 10% more before it goes into fatigue. 10% is a significant improvement for both top-end athletes and daily living.
Alan has done a clinical trial that showed a 25% to 30% drop in fatigue levels within six weeks, even for people with chronic fatigue syndrome or ME/CFS for up to 30 years. NF-κB turns on genes that release a cytokine storm, which at high levels can lead to chronic inflammation seen in arthritis or long COVID patients.
Animal models show that oxaloacetate led to a reduction of NF-κB’s translocation to the nucleus by 70%, which turns off the cytokine storm.
People experiencing chronic fatigue can benefit from oxaloacetate’s mechanism of producing new mitochondria.
In animal models, oxaloacetate turns on the mechanism to increase the number of neurons in the brain and increase the length of the axons, the little tendrils that connect neurons.
Alan did a critical trial on the effect of oxaloacetate on premenstrual syndrome (PMS), wherein he found a 50% drop in anxiety, depression and suicide ideation.
Drugs have an immediate pharmacological effect. Another is the genomic effect with a cumulative property that takes about a month or more to see.
Even after getting better from your illnesses, keep the ball rolling and don’t stop intaking your medicine and supplements.
‘We could see when we gave the oxaloacetate to them if they live longer, or if they didn't, so we could eliminate what were the critical genes. And, we were able to follow along with a pathway, and it turned out to be the exact same pathway as calorie restriction, which is really exciting.’
‘First of all, is oxaloacetate toxic? Well, it turns out it's a human molecule. It's in metabolism. It's in practically every cell of your body.’
‘Experiment and see what works and understanding some of these mechanisms is really important because then we can actually start to connect the dots of cells.’
‘The reality is most people are not going to have the perfect diet, not going to be in a perfect environment, can't maybe even afford to have great food, or organic food, or all of these things that restrict us from having the ideal.’
‘None of us are going to know what's around the corner for us but, if we can be in that preventative space and be understanding this more and more, then that is to me the most fascinating conversation we can have.’
‘What happens then is that they stop all their protocol, and the thing that they were doing and, “Now I'm fixed. I don't need it anymore.” And I'm like, “Hang on a minute, you don't drop the ball now. You're already underway. You got to stay underway. You got to keep it going.”’
‘You want that cumulative, and those epigenetic changes, and those long term changes.’
Alan Cash is a physicist, biologist and geologist. He's also a professional entrepreneur and the CEO and Founder of Terra Biological LLC and MetVital, Inc.
Alan is also the clinical trials supervisor and medical researcher. He’s currently pursuing the advancement and development of nutritional supplements containing oxaloacetate, which is known as a caloric-restriction mimetic compound. His research has brought profound breakthroughs addressing cognitive decline and anti-aging.
If you want to reach out, you may connect with Alan via LinkedIn.
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