In this week's episode of "Pushing the Limits" I interview the incredible Dr Ross Pelton AKA the Natural Pharmacist.
Ross Pelton is a pharmacist, nutritionist, author and a health educator who is widely recognized as the world's leading authority on drug-induced nutrient depletions. He was named one of the top 50 most influential pharmacists in the United States by American Druggist magazine for his work in Natural Medicine.
He is the author of 13 books including his latest one which we do a deep dive into today on Rapamycin and longevity science
About the Book and what you will learn about in this episode
(Disclaimer: none of this is medical advice, it is for educational purposes only)
Rapamycin, mTOR, Autophagy and Treating mTOR Syndrome
We discuss how the prescription drug rapamycin can increase longevity. After the discovery of rapamycin, scientists began conducting experiments in an effort to understand rapamycin's mechanism of action. This led to the discovery of mTOR, which in turn, led to the understanding of how mTOR and autophagy regulate cellular metabolism and ultimately, the health and life of all living things.
The discovery of rapamycin resulted in scientific studies that have enabled scientists to gain a totally new understanding of the aging process and how we might use this new information. The topics in this book are collectively one of the most important breakthroughs in the science of life extension that has ever been discovered.
Discovery of Rapamycin:
Strain of bacteria named Streptomyces hygroscopicus
Discovered from a soil sample taken from Easter Island
Exhibited anti-proliferative properties
The bacterium was discovered from a soil sample taken during a scientific expedition to Easter Island in 1964. The purpose of that expedition was to search for new compounds that might express antifungal and/or antibiotic properties.
Rapamycin expressed strong antifungal activity. However, efforts to develop rapamycin as an antifungal drug were discontinued when it was discovered to have potent immunosuppressive activity.
Rapamycin also exhibited anti-proliferative properties, which prompted scientists to send samples of rapamycin to the National Cancer Institute (NCI). Tests conducted there revealed two remarkable findings. The first revelation was that rapamycin suppressed the growth in a variety of solid tumors.
Rapamycin's Mechanism of Action
Over the past 25 years, research into rapamycin's mechanism of action has resulted in the discovery of a new understanding of cellular biology and the aging process.
This research has revealed that two mechanisms named mTOR and autophagy, which are found inside every cell, are critical regulators of cellular metabolism.
Breakthrough: Rapamycin's Use in Humans
A groundbreaking study titled mTOR inhibition improves immune function in the elderly was published that ushered in the era of rapamycin use in humans. The study was conducted by Joan Mannick, MD, who was a senior scientist at Novartis.
In addition to being a human clinical trial, Mannick's study is important because it sheds light on WHY and HOW rapamycin can be used safely and effectively in humans to slow down the onset of age-related diseases and increase lifespan and healthspan.
We also discuss drug induced nutrient depletions.
You can find Dr Ross at:
https://www.naturalpharmacist.net/
Also check out the Anti-aging range of supplements and information at https://theantiaging.store
You can get Dr Peltons book here:
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