Pushing The Limits

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Here are three reasons why you should listen to the full episode:

Discover the benefits of orthotics and modern imaging techniques in foot health.
Learn more about common running-specific injuries and ways to prevent them.
Know about the brain-foot connection and the knock-on effect of footwear.

Resources

The Foot Strength Plan by Colin Dombroski
The Plantar Fasciitis Plan by Colin Dombroski
Born to Run by Christopher McDougall
The Ben Greenfield Fitness Podcast
SoleScience
Connect with Colin: Website | Email | Facebook | Skype: solescience

Episode Highlights

[03:14] Colin’s Background

Colin designs and manufactures custom foot orthotics.
His researches revolve around general footwear, lower extremity therapy, and how these things interact to make people better.
Colin works on 3D printing orthotics, which shows how the foot works or moves in real-time.
He works with people to get them back on their feet and do what they want to do.

[04:36] How Foot Imaging Works

Colin uses a 3D motion analysis lab to study the workings of the lower extremities.
Alternatively, he also partners with the WOBL lab to do biplanar fluoroscopy. This procedure maps out somebody’s foot in 3D space.
It helps understand what is happening to the foot in real-time; it shows feet in a shoe under different circumstances.
Colin looks into the best way to make an orthotic for someone.
Imaging helps to see what is happening in the foot when a person is barefoot, in a shoe, or using orthotics.

[09:56] Are Orthotics Generally Good?

Orthotics are neither good nor bad; we cannot generalise.
It may be suitable for someone with arthritis but may not be beneficial to someone with no problems.
Orthotics are used as tools to help people with recovery and performance.
Colin’s job is to tell people whether they need orthotics or not.
When they have done their job, they’re removed.

[12:57] Rehabilitation vs Orthotics

In mild foot aches, over-the-counter devices can work well.
Orthotics are not a first-line treatment for some conditions.
Look at other things first before going down the route of orthotics.
Foot strengthening is very beneficial.
Do simple things that make feet work as feet.

[16:55] Does Wearing Shoes Result in Weaker Feet?

Not walking for a few blocks is just as harmful as having shoes that do not fit you.
Poorly fitting shoes can be bad for you.
Women wearing high-heeled shoes for a long time can have a lot of foot problems later on.
Colin recommends we exercise moderation when wearing heels.

[25:15] How to Prevent Running Injuries

Injuries usually result in a mismatch between the style of a person’s foot and the kind of shoe they wear.
Footwear should fit into your foot design so you don’t cram your toes.
Some shoes may fit while you are buying them in a store, but they may end up not fitting at all or when you are already running long distances.
If you don’t know how the sock liner, width, toe spring, and heel drop of the shoe interact, the potential for injury is more significant.
Listen to the full episode to learn more about the running injuries that Colin has encountered and how to prevent them.

[32:42] Running on Concrete vs Running on Natural Terrain

The natural terrain is easy to run on compared to concrete.
Mitigate the force of initial contact to avoid injuries.
Listen to the full episode to learn more about what type of shoe you need for different surfaces.

[34:29] On Transitioning Your Footwear

If you want to go barefoot, do it gradually.
Scientific literature has discussed the importance of transition shoes.
If you’re going to drop your 10- to 12-millimetre heel drop shoe to 4, you need to have a 6- to 8-millimetre transition shoe.

[37:22] How Often Should We Change Shoes?

Do not let shoes sit on shelves for more than two years because the material stiffens.
In general, alternating shoes are good after 6800 kilometres.
However, this still depends on how quickly you wear out the outsole of your shoes.
Having shoes with different heel heights for different types of running would be very beneficial.

[42:59] The Brain-Foot Connection

When you ignore stabilisers and prime mover muscles, you get a mismatch in balance and performance.
It’s important at the lower leg holistically.
Colin acknowledges that we get a different sensation if we’re barefoot versus when we have socks and shoes on.
However, it’s a misnomer to say that putting on footwear reduces your proprioception or sensation.
Your brain adjusts to the sensory input being thrown its way.

[48:39] Achilles Injuries

Achilles injuries result when people change the drop of their shoe or change their running style too quickly.
There is a genetic predisposition for people with Achilles issues.
Using things like heel lifts in footwear takes some load off the Achilles, allowing it to heal.
Any ankle restriction can make you use your Achilles differently.
Listen to the full episode to learn about the importance of a multidisciplinary approach in looking at conditions.

7 Powerful Quotes

‘If someone's not getting the right kind of results, it could be that they just need to be adjusted. But then some people don't believe that they need to be adjusted. They believe your foot functions best one particular way’.

‘I think that a lot of people have lost the ability to connect with their brain and their feet and they need to get that ability back’.

‘It's not putting everything into a box of good or bad, you know, but it's looking at it holistically’.

‘We get back to my point where [we do things in] moderation. There's a time to spend time in the sand, there's a time to spend time in the trail, and there's time to get on the road’.

‘If you can get that little bit of variability where you're lengthening some days, you're shortening some days, you're doing different things and your body is used to that, then you're going to be more adaptive. But if you lock into that one pattern, it's going to be so much harder to change’.

‘You also need to have a really good understanding of the whole anatomy of the body because you have to be holistic in your approach’.

‘You know your limits better than somebody else. But I think that there's also a time when you do need to respect the knowledge that someone's gone and spent time attaining.

About Dr Colin Dombroski

Dr Colin Dombroski is a podiatrist and a foot specialist of 20 years; he is also an author and a researcher. He works in the world of shoes, orthotics, rehab, and range. He specialises in any feet issues, from plantar fasciitis to Achilles injuries.

Connect with Colin through his website. You may also reach out to him through email or Facebook.

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To pushing the limits,

Lisa

Full Transcript Of The Podcast

Welcome to Pushing The Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com.

Lisa Tamati: You're listening to Pushing The Limits with Lisa Tamati, your host. I have a fantastic gift again for you today. Gosh, I managed to come up with some amazing people. So I have the guest Dr Colin Dombroski, who is a podiatrist and expert on everything foot. He's known as the foot specialist. He is the author of two books, Healthy Strong Feet, and The Plantar Fasciitis Plan. He's a researcher, and also has a shoe—a specialist running shoe shop. He knows everything about the cutting edge of foot health.

So this is a topic that's really important, obviously, for all the runners listening out there. Or if you're having any sort of issues with your feet, maybe you're dealing with plantar fasciitis, maybe you have to have orthotics, or you've got arthritis, or you've got bunions, or you've got problems with your Achilles or further up the kinetic chain, then this is the episode for you because we're going to be talking about the cutting edge of science. Dr Colin is really up on the latest thing. He has all the fancy gadgets in his lab that he does. And so it's a really, really interesting conversation that I have with Dr Colin.

Now before we go over to the show. If you are also looking for—doing a running training plan that fits your life and without having to think about how to assemble the entire plan yourself, then please come and check out what we do at Running Hot Coaching. We have a brand new package that we now offer and there's a fully customised package to you, to your goals, to your injuries, your lifestyle, anything that's holding you back, and we can customise it to you. And you'll also get full video analysis done with this package and a one-on-one consult with me in a personalised plan for your next event. Whether that be a marathon, a half marathon, ultramarathon, 10K, it doesn't really matter that's up to you. And you get 12 months of access to Running Hot Coaching’s whole resource library and all the other plans that are available on me, so it’s a super, super deal.

You also get access to our community of over 700 runners from around the world that we get to coach nowadays and hang out with them. And also we do live events on occasion and do regular educational webinars and so on. So everything running. If you want help with it, then we would love to help you get in—make the best out of your running. Okay, so check that out at runninghotcoaching.com.

Right, over to the show now with Dr Colin Dombroski.

Lisa Tamati: Well, hello, everyone. Welcome back to Pushing The Limits. It's your host, Lisa Tamati here. And today I have Colin Dombroski with me, all the way from Ontario in Canada. So welcome to the show, Colin. Fantastic to have you.

Dr Colin Dombroski: Thanks so much for having me.

Lisa: It's really, really exciting. So I am going to be talking to you today about feet. You are the foot guy. You are known as the foot guy. Colin, can you give us a bit of a brief background, why are you known as the foot guy?

Dr Colin: Well, I mean, I'm a Canadian certified podiatrist first and foremost. So I'm trained in both the design and the manufacturer of custom foot orthotics, foot orthotics in general, footwear and lower extremity therapy care, and how those things interact to get people better. And so, we started that back in 2002. And since then, I've gone on to do PhD work in Health and Rehabilitation Science, and research and everything from the basic 3D printings of orthotics to how the foot’s actually moving in a shoe using things like a biplanar fluoroscopy and CT imaging to really understand what's actually going on, as opposed to just kind of guessing and thinking about it or looking at video without actually being able to see inside the shoe.

And so we've seen tens of thousands of patients. We've worked with people over the last 20 years, really working to get them back up and on their feet and doing the things that they want to do to stay healthy. And for some people, it's as simple as walking around the block and for other people it's going to the Olympics in Tokyo.

Lisa: Wow, fantastic. So you're deep into the science...

Dr Colin: Yes.

Lisa: ...of the absolute cutting edge of what we can do now for foot issues and optimising foot health. So tell us a little bit about some of the fancy stuff that you can do, like, how that—you said there you can look into the inside a shoe or...

Dr Colin: Yes.

Lisa: ...rather than just looking at video. How does that work?

Dr Colin: I'll tell you on the research side, there's all kinds of fancy stuff that we were able to do. And so, right now I have an academic appointment through Western University in the School of Physical Therapy. So, I'm lucky enough to be able to do research in what I do specifically. So—and we can do that in a couple of different ways. One is that we actually have a full 3D motion analysis lab at our main business in London Ontario. So it's seven Vicon cameras, much like the way you would see motion analysis for video games or for the movies.

Lisa: Wow.

Dr Colin: Well, we use that to study how the lower extremity works in the human body. And so we can either put markers on the foot and cut windows into the shoe, so we can see how things move. That's one way to do it. The other way that we've done it is working with another lab called the wobble lab, and they have two movie x-rays, or what's called biplanar fluoroscopy. And then what we can do is have a CT of somebody's foot, we can take those bones out, we can map them in three-dimensional space. And at 17 times per second, we can move that bone model on top of the actual movie x-ray model to understand what's happening to the foot and the bones in real-time in a shoe, under different circumstances, whether that's no orthotic, orthotic, and we can compare that to their walking barefoot as well.

Lisa: That is insane Colin. I have no idea.

Dr Colin: Yes. it's a cool thing. And if you go on the website, if you go on—I think we have a fluoroscopy video up on stuff about feet. But if we don't, there's certainly one up on the research section of SoleScience, and you're able to actually watch, you can see what we're looking at through this thing.

Lisa: Wow.

Dr Colin: And it's really cool to know. And what's really interesting when we look at this stuff is that we wanted to know when we make somebody an orthotic. What's the best way to do that for someone? There's different ways that we can capture somebody's foot, whether we use a foam or a wax method or a plaster mould of somebody's foot, we wanted to know kind of based on a couple of different styles, which one might actually control the motion of their foot a bit better. And we were able to show that one was more effective than another—made a small amount with a very specific foot type.

So, if you have a flatter foot, there are ways of making it that are more effective. But what was really interesting out of that was to look at what was actually happening with the foot when someone was just walking barefoot, when they were just walking in their shoe, or when we put an orthotic in there? Because you know if I can go on a bit of a tangent, there's lots of scary stuff on the internet these days about how, ‘Oh, you don't want to walk in shoes and orthotics because it makes you act like you're walking in a cast. And why would you want to do that'?

Well, what's really interesting is that when we looked at someone's foot walking barefoot, and we compared that to the most supportive thing that we use, they still kept up to 96% of their original motion.

Lisa: Wow.

Dr Colin: So, think about that for a second, 96% or one motion.

Lisa: Yes.

Dr Colin: So, you're really at that point, if someone's keeping that much of their original range of motion, you really have to wonder, ‘What are we actually doing with these things?’ And I'm going to argue that it's more than just the shoe on someone's foot. It's more than just the device in that shoe, that there could be a lot more actually going on with these things than we fully understand even though we have the best research methods to be able to look at it.

Lisa: That's amazing. I mean, I'm really, really interested because with orthotics, I've recently gone and got my mum an orthotic and you don't know my mum's story. But she had a massive aneurysm five years ago, has dropped foot on the right side, incredible rehabilitation journey, written a book on it. But we're not having such success with the orthotic yet. We are having success with a Dictus where it's helping lift her foot. And I've had in the past two experiences with orthotics when I've had different issues, like, I can't remember now what specifically, I think it was plantar fasciitis. And I've tried different things, admittedly a while ago, and things have obviously moved on. But I haven't had that much success.

So I'm like, as a running coach, I should know more about the latest in science as far as orthotics go. And whether they're my initial reaction back then was, ‘Well, I don't think orthotics are really working for a lot of people’. That's been the feedback from other people as well. So obviously, the science has moved forward and it is offering new insights and you can actually see in real-time what our bones are doing. I mean, it's just absolutely mental, that's crazy and cool. So do you think—isn't it like walking around with a cast on your foot? We've got this whole barefoot craze that's been in the last few years and then we've got brands like Hoka One One coming out with really cushions. So, I think people are a little bit confused as to what they should be doing.

Dr Colin: Yes, and rightfully so.

Lisa: Our orthotic is good. Our orthotics in general is—can we generalise when it's very specific.

Dr Colin: Nope. Not at all. We can’t generalise it all and that's the problem when it comes to this stuff is that people are trying to fit everybody into a box. And saying that either it's really good, or it's really bad. It’s either of those things? Like, to the end of the day, if you really need them, if you have rheumatoid arthritis, and you're unable to walk around the block, and I'm able to get you active again, they're really good for you.

Lisa: Yes, absolutely.

Dr Colin: Right? But if you have no risk factors, if you have no biomechanical abnormalities, if you have no foot deformities and no other issues, then what's the benefit of wearing them at the end of the day? And so to that end of things, a lot of the time, I feel as though we're missing the middle ground. We're missing the fact that people can use these things, either as a tool to help them with recovery and performance that we can then work to wean them off, if they so choose, or if they need to be, or we use them because there's a real thing where structure dictates function and injury.

But again, why are we looking to see whether or not people are either yes or no, off or on? It's more of a continuum. And I kind of like to look at people and the fact that over on this end of the spectrum, here, you've got people who are so gifted biomechanically that they can do anything they want to do, despite doing it wrong. They can go couch to marathon in old worn-out shoes with poor sleep with bad nutrition, and they can do it and they don't get hurt. And you've got people on the other end of the spectrum that can do everything, right, and work with the best coaches and get the best equipment and eat and sleep and everything else. But they're plagued with injury, right?

Most people are going to be somewhere in the middle, the question though, so, which side of the spectrum do you lie more towards? And that's where I feel my job comes in, is to figure out where that is, and then how to appropriately apply these things, whether or not you actually need them. And I build a business on telling people when they don't need them.

Lisa: That's brilliant.

Dr Colin: And when they don't need them anymore. So, it's actually quite shocking when someone comes into my office for their ninth orthotic, and I say, ‘Well, tell me about it'. And so they—we talk about stuff, and we come to the conclusion that they just don't need them anymore.

And they're shocked, they think that these things are like a lifelong sentence. And they're not. For some people, they are the difference between being able to be active or not. And for other people, there's simply a tool, and we use that tool appropriately, and we remove it.

Lisa: That is absolutely gold, Colin. And what a fantastic approach in, like, working with people with disabilities and stuff, I know there are definitely times when we do need them, and they're going to benefit and it is very much about the skill of the person who's fitting the orthotic and knows, obviously, what they're doing. And there’s a lot of advertising out there; rubbish sort of advertising that you see with different standard gum, pick it off the shelf type things, what's your opinion on those types of orthotics?

Dr Colin: Well, I mean, if those—so, if something like that, like if an over the counter device works for you, for—let's say you have a mild case of metatarsalgia. Let's say you have a small ache in the front part of your foot when you're active, and you've done all the rest of the conservative therapy things. You're strong, you're flexible, everything else is ticked off, and you're still not doing well. Sometimes removing that little bit of mechanical stress can be enough that allows the tissues to heal and you can move on. Right? So in those cases, yes, they work quite well.

But in some cases, if you have a foot type that doesn't match up with that shaped plastic that's pushing against your foot, it might not work so much. And kind of to your point where you were saying you had them for plantar fasciitis before, and they just didn't work for you, it could be a multitude of reasons why they didn't work for you. And we see that all the time.

And if someone's not getting the right kind of results, it could be that they just need to be adjusted. But then some people don't believe that they need to be adjusted. They believe your foot functions best, one particular way. And they say, ‘Here, this is for you. This is the way it should be, get used to it'.

Lisa: And then it's the whole side of: you should be doing strengthening exercises and rolling and stretching. What's your take on the whole on that side of it? So the rehabilitation side of it as opposed to the orthotic side of the equation?

Dr Colin: Well, so my—the way that we teach about orthotics is that orthotics for some conditions are not a first line treatment unless you have significant risk factors. If you're diabetic, then yes, 100% we're making you orthotics. But for a lot of people especially let's take plantar fasciitis for instance. If you come to me and you've had plantar fasciitis only for a few weeks, there is a whole host of other therapies that you can try before you even need to think about that. Is removing the stress off the tissue, the strain off the tissue with the device and footwear appropriate? Heck yes, it is. But there are other things that you need to look at first before you even go down the route of orthotics which is actually why I wrote my first book. And it's to tell people the things that they can do at home to be able to get themselves better for four to six weeks before they have to see somebody like me to think about orthotics.

Lisa: Okay, so what was the title of that book, Colin?

Dr Colin: Oh, it's called The Plantar Fasciitis Plan.

Lisa: The Plantar Fasciitis Plan and that is available on Amazon?

Dr Colin: Yes.

Lisa: Okay, so in New Zealand, we might struggle with Amazon, but we don't have Amazon down here, believe it or not.

Dr Colin: I have no idea.

Lisa: We can access it, but some things can ship from over the air and some not so. But we'll put the links in the show notes for sure for those listening who are overseas and want to read that book. Okay, so you mentioned...

Dr Colin: And to speak to your last question...

Lisa: Absolutely.

Dr Colin: ...which was, what do you think about the whole foot strengthening part of it?

Lisa: Yes.

Dr Colin: I think it's very important, I think that a lot of people have lost the ability to connect with their brain and their feet, and they need to get that ability back, it's shocking how many people I see that can do something as simple as move their toes, or lift their arch, or do some of the simple things that they need to do to make feet work as feet. Right? And so, getting them back to that foot connection is only a positive thing. Like, the only good things are going to come out of that.

Lisa: So, is this like, is this a problem of the modern human because we've walked around in shoes. Did humans, before shoes come along, did we all have great feet? Strong powerful feet because we were barefoot from the get go? So is this a problem of the modern human but like with—I've just done a couple of episodes on breathing and the way that we are chewing is affecting our structure of our mouth and therefore we're not having such good breathing and so on. Is that similar sort of case?

Dr Colin: I really think that when you talk to a question about that, it's really hard to compare those two things because we're just not there right now. You know what I mean? So, yes, if we didn't wear clothes, and we didn't drive cars, and we didn't eat the way that we did, yes, things would be different than where they are. But like, we drive our cars to go five blocks down the street to get to Starbucks, we don't walk. So, that alone is just as deleterious as footwear that doesn't fit you properly.

So when it comes to shoes, again, there's lots of scariness out there on the internet, talking about how these things, again, make you walk like your cast or is deforming your feet. And yes, I would agree that a poorly fit shoes that are way too tight cramming your toes, putting stress on nerves and tissues certainly can be a bad thing for you. But do I think that there's this gigantic conspiracy out there that's making the collective feet of the world less strong and everything else? No, I really don't, to that end. And again, as a recovery tool, they can be marvellous things if done correctly.

Lisa: Yes, it's a really good approach. I mean, it reminds me of my dad's feet. My dad who recently passed, unfortunately. But my dad had the most amazing, strong, powerful feet, he grew up in the first 13 years of life and not wearing shoes. Came from a very humble background with eight children, and they only had one pair of gumboots in the family. So he grew up with these incredibly powerful feet.

By the time he was in his 50s, 60s, 70s, and 80s, he could walk around barefoot all day, never have any sort of problems. The state of his heels weren't the best. But muscular feet, really strong powerful feet, because he didn't wear shoes until he was older and then still like to go barefoot whenever possible, actually connected to the earth, weed garden all day, and their feet at the most jungles. So I did see it in that. Quite the effects of having that real connection to Mother Earth if you like in developing those sort of strong muscles in our feet.

And then on the other side of the equation. I see people with diabetics or close to being pre-diabetic problems with extremely tender feet and poor circulation in the feet and their feet are just not moving well and have always been in shoes. So it's like opposite ends of the scale via. So, where was I going with this? There's a real broad range of where people are at. Another thing that I think is to consider is women in high heeled shoes, what's your take on that sort of a problem? Like, were lifting your heels up and having a shortened calf. And that's sort of a problem.

Dr Colin: Well, I mean, that for too long of a period of time just gives you a whole myriad of problems from metatarsalgia, and progressing bunion issues, and nerve problems, and chronically short Achilles because of that shortening specifically, yes. I mean, we see that all the time. I'm very much a fan of moderation when it comes to these things.

And so for a lot of my patients, if they want to spend an evening, every now and again, where they're primarily sitting in a pair of heels, then I feel as though the trade-off for what they get out of that is okay, comparatively. Again, it's not putting everything into a box of good or bad, but it's looking at it holistically.

Lisa: Brilliant. I think it's a really good approach.

Dr Colin: Yes, if you're a retail worker, and you're spending 10 hours a day, on your feet, heels are definitely not the thing you want to be wearing.

Lisa: Yes, you've got to sacrifice the elegance, ladies. Sometimes you help that little pushes.

Dr Colin: A little bit sometimes. And you know where I end up seeing that a lot? It’s in lawyers. A lot of my patients who are lawyers. There is definitely a culture of dress code and professionalism that comes from wearing heels. And I see a lot of injured lawyers because of that, specifically.

Lisa: Isn't that interesting? So yes, really take heed because I do think doing that on a daily basis, yes. The odd night out in a pair of heels to look elegant is fine, but not doing it every single day, were you really shortening, I mean, just, I'm always sort of relating things back to my life. But with mum having aneurysm, being bedridden pretty much for 18 months before we could get her standing. And I didn't understand at the beginning about drop foot, I missed the boat. And by the time I realised what drop foot was, that had happened very, very quickly, that her foot was now dropped until we're still working on that right through now, to be able to lift set front of the foot up and having to use a Dictus in her case, which lifts the front of the foot up. So it happens very—it happens quicker than what you think.

Dr Colin: It can, certainly. Yes. Now the brace that your mum's using, do you mind if I asked you a quick question? Is she using an over-the-counter one or a custom one?

Lisa: So it's an over-the-counter Dictus one as I didn't know there was such a thing as a customised Dictus. So it's just a leather strap that goes around with a rubber that goes over inside these two little hooks at the bottom of the shoes that pulls the shoe up. So is there something better, Colin?

Dr Colin: Well, so, take a look for something called an Allard ToeOff AFO. And we use them a lot in clinics for patients with drop foot and they're actually designed to be to run marathons and events and they're quite robust.

Lisa: Okay, I’ll take note of that.

Dr Colin: And it might be a great training tool too. They're very light. You should wear them under a pair of pants. A lot of people like the fact that they don't see the direct brace.

Lisa: Yes, yes. Yes, exactly. This one's quite ugly. So, is it Allard?

Dr Colin: A-L-L-A-R-D.

Lisa: Oh, brilliant.

Dr Colin: So as in Allard ToeOff.

Lisa: Allard ToeOff, I will check that out. See, this is a selfish reason why I get to talk to experts.

Dr Colin: There we go.

Lisa: Because you never know when it's gonna help somebody you know? It's fantastic. I'll check that one out. Yes, because that is a real problem. And there's so many—this is not a rare thing, drop foot. It's a very, very common thing with people with strokes and aneurysms and the like.

Dr Colin: It is.

Lisa: So, there's a lot of people dealing with it so going into the rehabilitation side of things. We have a shoe that has a rocker so she's able to toe-off slightly better in that rocker and keep her center of mass moving forward. Rather than sitting really back which she was doing. So yes, so I'm always looking for the next best thing for my mum from the show. So, appreciate that.

Dr Colin: No problem. And since you're a runner and all that stuff, the Asics Metaride is my favourite carbon shoe rocker. We've got so many people who really require surgery, fusions, things like that because of osteoarthritic toes or ankles or mid feet that can get into a shoe like that.

Lisa: Wow.

Dr Colin: And for people who are that age, they're not nearly as flashy looking as some of the other carbon rockered shoes that are available.

Lisa: Yes, but who cares as long as they function properly. Okay, Asics Metaride. Okay, we'll check those one out too. Now let's jump ship and change direction a little bit and go into running specific injuries. So we did touch briefly on playing to the shortest. But what are some of the common injuries that you see? And what are some of the ways that we can prevent? And how does it have a knock-on effect? Like what happens in your feet, knocks on the kinetic chain, doesn't it?

Dr Colin: Of course. Yes. So what I take a look at, the one of the biggest things are going to be mismatches between the style of foot that somebody has and their mechanics and the kind of shoe they wind up getting into. And so there's nothing like being able to mismatch the way that your foot wants to move, and then a shoe that's going to either work completely and pushing it in the same direction. So for instance, if you're a supinator, where your foot rolls to the outside, and then you get into an anti-pronation shoe, which a lot of people are—there's actually been research to show that runners are poor judges of their own foot type.

Lisa: Right.

Dr Colin: And if they get into that kind of footwear that makes them into more of a supinator. I can't tell you how many lateral column foot pain problems we see and perennial overuse problems and things like that. So simply mismatching your footwear to what your foot is doing can be one of them.

Lisa: Okay. Getting on and off the shelf is not, and diagnosing yourself is probably not a good idea if you're a serious runner who wants to do some serious racing.

Dr Colin: Well, maybe it's a good idea to run your findings by someone else who can take an objective third-party look at you. And so some people think, ‘Oh, my foot is so flat, I need to get into this kind of footwear'. And that might not always be the case when it comes down to it. So the footwear component of it is so big. Making sure that it actually fits the way that your foot is designed. So if you have a particularly wide forefoot and a narrower rear foot, looking for things that actually match up with that, so that you're not cramming your toes into a pair of shoes.

Lisa: As a run coach, if I can just pipe in there that has been one of the biggest mistakes that I've seen so many athletes buy. They go into a shoe shop that does foot analysis, and they proceed them on a treadmill and so on. So they may have the right type of shoe, but they're after buying the shoe in a cold state. So i.e., they've just walked into a shop, they haven't been on their feet all day, they haven't been running for 30K's, their feet are not swollen.

And then they go and if they do marathons, or especially ultramarathons, their feet are swelling. And especially I've seen this in women where we tend to swell tissues in my opinion, not scientifically-backed or anything but my observation is that women's feet swell more than men. And the size of the shoe is then way too small, especially in the toe box. And this often leads to pain on the top of the foot and the cutting off of circulation there. And I've seen problems with the shins and so on.

Have you—is it a thing? Have you seen this sort of a trend as well, where they're going into the shop, and it's fitting in the shop on the day that they buy it, but when they're long-distance runners, that becomes a problem, especially when they're running under heat?

Dr Colin: 100%. Yes, I mean, fatigue is one of those things that wrecks everything. But at the end of the day, when you're not fatigued, and you're ready to take a pair of shoes, and you're trying it on, you don't know how the inside of your ankle is gonna rub against that shoe until you've spent 30, 40, 50k in it to really understand what's happening there. So the idea that something is going to ‘break in’, in quotation marks is something that I like to try to shy away from as much as I possibly can.

The biggest issue that we see from most people is they just fit them incorrectly, right? They fit them too short. And so if things do swell, if there's movement or any of that stuff, you're going to get problems along with the feet, whether it's friction and blisters or black toenails, or what have you. The length of that, and then especially the curve of the toes, makes such a big difference.

And so, a lot of footwear stores these days might not carry the full breadth of width available. And so for instance, New Balance comes in ladies from a 2A to a 2E and everything else in between.

Lisa: Wow.

Dr Colin: So it comes in a 2A, and a B, and a D and then a 2E. So when you have to carry four widths of shoes from a size 5 to a size 13...

Lisa: That’s expensive.

Dr Colin: ...including half sizes, that's expensive. And that's only for one colour.

Lisa: Wow.

Dr Colin: Right? So when you think about that, you understand why you might not be able to find the full breadth of width in a lot of these things. Because shoe stores will have a hard time selling through and if they can't, they can't make money and stay open. So, but if you're one of those people that are on either end of the spectrum, then you need to find a place that will cater towards those kinds of things and that understand the nuances and the differences within brands. So, I mean I've seen people go up a full size in between different models of shoes within the same brand of a company.

Lisa: Wow.

Dr Colin: So, for instance, the New Balance 880 and the New Balance 840 fit completely different. The sock liner is three times as thick, the width is more, the toe spring is different, the heel drop is different, all of that stuff. And if you don't know how each one of those things interact with someone, then the potential for injury is just greater.

Lisa: Wow. And yes, I can definitely relate to that having had—I've had many different sponsorship agreements over my career. And some of the companies, a couple of them, I had to actually leave because I just could not wear their shoes and they were so different in other ones that I just absolutely loved and were able to stick with. And I've got a very wide foot. And so I have to be in a men’s shoe. But when I was doing desert races in extreme heat in Death Valley and the likes, I had shoes that were two sizes too big for me.

Dr Colin: Wow.

Lisa: So, that's what I worked out was the sweet spot. So at that point, I wouldn't get the blisters and I wouldn't get the black toenails, and I wouldn't get the foot just swelling so much that it's boosting out the sides of the shoes and putting pressure on top of the foot and causing—and I've had it all awful shin problems by having that circulation cut off at the top of the foot.

I remember a race I did in Germany 338 kilometres in five days. So, we're doing 70 kilometres a day. And after day one, my shoes were just way too tight. And by then the damage was done. And an old-timer, who was in the race, said to me, ‘Hey, you need to cut your socks and open your shoes right up'. And that was a piece of advice that I carried with me being from the norm because, and I ended up doing that very often. So even something like a pair of socks that is too tight around the ankle can cause shin problems. I mean, I've experienced that firsthand, and on the top of the funnel as well. So it really makes a heck of a difference, isn't it?

Dr Colin: Oh, it's so does and you know, when you're looking at the trail shoes and things like that, the choices become even more frustrating.

Lisa: Yes, yes, yes. Yes, let’s talk trail because what trail—we weren't as humans, like, we didn't evolve to run on concrete and pads. So what's your take on how bad is it to be running on roads and concrete versus the natural terrain of a trail so to speak?

Dr Colin: Well, I mean, certainly the natural trait of a trail is going to be easier for you to run on versus concrete and asphalts and those types of things. And when we looked at the literature, and some of the research said that it's—there's been a lot of fun running research that's come out in the last 15 years. But a lot of our initial contact strategies, so whether you stride on your heel, your midfoot or your forefoot, a lot of it has to do with mitigating the force of that initial contact. And so if you're running on an incredibly hard surface, you might adapt to changing your initial contact to be able to mitigate those loads of that initial load.

Whereas when you have a softer, spongier service to do on, you have a bit more leeway to be able to stride in a different pattern. And so for people who are rehabbing from injuries, yes, getting into something that's a little bit spongier is certainly going to be more forgiving. Now, you can take that all the way to running on the beach, and that causing some problems as well just from the increased biomechanics that that causes too. So to get back to my point where moderation.

Lisa: Yes.

Dr Colin: There's a time to spend time in the sand, and there's a time to spend time in the trail, and there's time to get on the road.

Lisa: And this trend it transition times, like when the barefoot craze hurt when my friend Chris McDougall’s book came out Born to Run and it sort of revolutionised everybody's thinking was like, ‘We gotta go barefoot because Barefoot Ted was doing it’. And we saw a lot of injuries come out of that. And no, no, no detriment on the book. It was a fantastic book. But people just went too fast, too far too fast. And we really need a transition time if we wanting to go barefoot. Would you agree with that?

Dr Colin: Oh, it's not a matter of me agreeing with it, that that's just a matter of scientific fact.

Lisa: Yes.

Dr Colin: I mean, if you want to go from—which so I do agree with it. To that end, yes. There's nothing that's going to increase your risk of getting hurt more than taking off your footwear and going for a barefoot run. If you're used to wearing a maximalist style of shoe, taking it off going barefoot for 21K, you'll be lucky if you don't come back with a stress fracture. And certainly, my practice has been a mirror of that, right? I mean, at the end of the day, I see injured runners all day every day. That's what I do.

So, I like to joke that the greatest predictor of running injuries is running. But to that end, if you want to make these changes, I think they're great for people. And I think that they're able to make these changes in a proper informed way. And so even looking to what some of the scientific literature says they talk about a transition shoe specifically, right? If you're going to go from a regular 10 or 12 mil heel drop shoe to 4, 0, having a 6 to 8 mil transition shoe wouldn't be a bad idea.

There's one company that will remain nameless that when they changed all their heel heights from 12 mil to 8 mil, and no one really understood what that meant. I can't tell you the number of Achilles problems and things that came into the clinic two years after that.

Lisa: Wow.

Dr Colin: Because making even that 4-millimetre change in someone who puts in 60 to 80 kilometres a week, and they're used to loading their tissues in a particular way when you all of a sudden change that with up to three times your bodyweight up to 10,000 steps, that's a huge change for your body all of a sudden.

Lisa: Wow, that is insane. Just from a very small change. And look we all—lots of people just swap different shoes ‘Oh try those ones, or this time, I'll buy those’.

Dr Colin: Yes, exactly.

Lisa: And so is it—and this is the other thing, brands keep changing.

Dr Colin: Yes, every season.

Lisa: ‘Ugh, damn. It's something new, it was perfect. And now it's gone again, I can't get it’.

Dr Colin: Yes.

Lisa: So by a couple of pieces, when you do get something that's right.

Dr Colin: 100%. But even that, don't let them sit on the shelves for more than two years.

Lisa: Oh, okay. Why is it? Do they degrade after that you sort of leave them?

Dr Colin: Actually the materials get stiff, the longer you leave them there. And so, that pair that felt really cushy a couple years ago, they let them sit for a couple of years, they're going to be harder...

Lisa: Oh, gosh.

Dr Colin: ...when you take them out of the box.

Lisa: Oh, okay.

Dr Colin: So you can't just let them sit for years on the shelf.

Lisa: And onto that note. How many kilometres? Like, how often should you be changing? I've always said between six and 800 kilometres max, what's your take on that? Is there a new science around that?

Dr Colin: Science is interesting when it comes to that. I mean, there isn't a lot of actual hard science on that. The soft science of it is to look at the bottoms of your shoes and see. If you're a heavier person, at your initial contact, and I don't mean heavy, like actually just a larger BMI. But some people, my wife is a light woman but she sounds like she's going to come through the floor, two floors down when she walks. And so she'll wear out the outsole of a shoe much faster than somebody who strikes the ground a little bit lighter. And so if you look at the bottoms of your footwear and let's say you're only 400K into a pair of shoes, but there's an angle now where the lugs are totally sheared off one side, that shoe was now forcing you to walk that way. And it's not helping your biomechanics at all.

And so yes, I think as it—as a general rule, 6 to 800 kilometres is okay. But if you're not, if you're training on consecutive days, and if you're training in one pair of shoes, you're going to break down the EVA material much faster because that material needs about 36 hours to rebound fully, before it's ready to go again. But if you're training 24 hours, you're going to break down your shoe much faster.

Lisa: Wow, that's a good point. I knew that. And I'd forgotten that fact. Thanks for reminding me of that because yes, alternating shoes on different days is something that I used to say, and I’ve forgotten completely about that one. So, that's a really good point. So, having a couple of pairs of shoes on the go, is a really, really good idea.

Dr Colin: Yes, 100%. And to that end too we were talking about, with transition shoes, and whatnot, having them even a different heel heights for different types of running would also be great. I mean, so while you're doing a fartlek training, or tempo run, or a long day might be different than what your ratio is, or the all day everyday shoe. And so that little bit of variability, I think, is a really positive thing.

When you get locked into one movement pattern all the time, then your body comes to predict that. And if you can get that little bit of variability where you're lengthening some days, you're shortening some days, you're doing different things, and your body is used to that, then you're going to be more adaptive. But if you lock into that one pattern, it's going to be so much harder to change.

Lisa: That seems to be the thing for everything in biology column. It seems to be a push and pull in a variety. You don't want to starve for too long, you don't want to eat too much for too long, you don't want to be too cold or in a thermoneutral zone for too long, you want—the body wants variety change. Not the same diet every day, not the same everything every day, and just by varying things up, we're giving our body a chance to get what it needs, and to have that variation—that push and pull that biology in all levels that I've been looking at seems to be cycling things. Cycling diet, cycling supplements, cycling shoes, cycling, changing in variety keeps the body guessing and keeps it changing, and keeps it so it doesn't go, ‘I've got this. And it's a piece of cake'.

Actually, I thought it just popped in my head. What do you think of Kipchoge shoes? The sub-two-hour marathon, the Nike shoes.

Dr Colin: Oh, yes. Yes, I mean, wow, there—this is a fun time to be alive for nerds like myself. So yes, I mean, there's some really cool stuff that Nike’s doing in some of their footwear. And they're—I mean, one of the leaders. But I mean, everyone now is coming out with a carbon plated shoe, and really aggressive rockers, and a lot of this stuff from a performance standpoint. And it'll be interesting to see how it's controlled and how it's covered. And to what lengths can we go to be able to increase the performance of humans? We developed things like oxygen deprivation to be able to increase your red blood cell counts, to be able to increase your performance. Changes in footwear like this are not that dissimilar from that. It's just a question of, how much can we use them? And how does it work with you?

Lisa: Yes.

Dr Colin: Yes, and what's gonna be legal.

Lisa: And at the moment, it is, isn't it? Like it's...

Dr Colin: It is.

Lisa: Yes. And I had a friend, who's a holistic movement coach, I had on the show, actually, a few weeks ago talking about feet as well, the health of feet. And he said, ‘I didn't want to like those Kipchoge shoes', but I— because he's very much into barefoot when possible and developing strength in the feet. He said, ‘But I put’...

Dr Colin: Well, that certainly is the opposite.

Lisa: He said, ‘I have to admit, I run a hell of a lot faster when I'm soaked’.

Dr Colin: Sure. Yes. But that comes back to the point of moderation, right? Is that there's a time for that shoe, just like there's a time to be barefoot. And it's using it in the appropriate fashion.

Lisa: Wow, that's brilliant. And okay, let's talk about the knock-on effect of how the feet which have and you know this 100 times better than me, there's just a ton of nerves, a ton of bones as most complex structure that we have, the proprioception, and the connection between the brain is just so important that we actually have that neurofeedback from our feet. So, what sort of a fix do—what sort of things can we expect to have happen on a good side from proprioception when we're doing lots of activity? And we're doing lots of different movement types and varieties of training? And how does it help our brain? The brain-foot connection, I think, is what I'm trying to ask you here.

Dr Colin: Well, I mean, anything that's going to make you more aware of what your foot’s doing in space is, again, only going to be a positive both from a balance and a performance perspective. It's striking to me that I can see some people perform incredible feats of athleticism, but then can't balance on one foot to do a pistol squat.

Lisa: Yes.

Dr Colin: Do you know what I mean?

Lisa: Yes.

Dr Colin: Because they just don't have control over their ankle. And so when people think of their feet, that's one thing. But I mean, the actual foot itself, though, those deep intrinsic layers of muscles are more stabilisers than they are prime movers, right? The prime movers are going to be higher up in the leg, and the tendons of those larger muscles in the leg support the ankle, right? They're the ones that are tibialis posterior, and the perennials and the things that actually wrap around the ankle. So it's a matter of looking at the lower leg holistically, not just the foot itself.

Yes, those little foot muscles are important. But I think oftentimes, some of the higher stuff up is overlooked as well as the actual prime movers and the actual real good stabilizers that way because those things are going to fatigue out relatively fast, and then you're left with the larger muscles to be able to do some of those things. But when you're not paying attention to one of those two, then you're going to get a mismatch in balance and performance. And so it's a matter of being able to look at more. It's about being able to use your abductor hallucis appropriately, being able to use all of those intrinsics to raise up your arch a bit and reduce some strain in your plantar fascia.

I would never go as far as saying you're going to change the structure of your foot by making your foot muscles strong, but certainly, you're going to get a better grip on the ground and you're going to be able to use your feet like feet and not just like a meat slab that hit the ground to be able to get to the next step.

Lisa: Yes, is it a bit like if I was to go around with gloves all day, and I wouldn't have the dexterity that I would need to do typing and learn to play an instrument or anything like that. Is that what's happening with our shoes, when we’re in shoes all day, every day, we're just taking away that connection to the brain and the brain's ability to be able to make those subtle adjustments with those little tiny muscles doing their thing?

Dr Colin: You can look at it two different ways, right? Because one might say that yes, if you're barefoot and you know you've got skin on the ground, you are going to get a different sensation than if you have sock and then something else between you and the ground. Right? There's just different feedback when it comes to it.

But to say that putting footwear on reduces your proprioception, or your sensation completely, is a bit of a misnomer. Because if you have something that's, let's say, a little bit squishier, and your foot’s moving around a bit more, well, that's also a signal to your brain too in terms of where to fire muscles, and how to fire muscles and using those muscles on top of it. So, I think we can go in both directions. And again, there is a time when it's going to be appropriate. And there's a time when you want to be barefoot and getting that sensory input in just a different fashion to say—because, at the end of the day, I just don't think it's realistic in the society that we live in that we're not going to be out of it completely.

Lisa: We don’t want to come from class, and you know...

Dr Colin: And so yes. So it's a matter of figuring out how to do that, in a fashion that's most appropriate, given the circumstances that you find yourself in.

Lisa: A bit of a left-field question and a bit of a non-scientific well, oh well, there's probably stuff coming out now. What's your take on having though the connection to Mother Earth and grounding? And that type of thing, and being in the dirt, so to speak, and having the actual contact with the earth? Is there anything to that side of things? Or is it just no scientific data really around that?

Dr Colin: There's absolutely nothing wrong with that, at the end of the day, and from a data and a science standpoint, I'm the first one to tell you that I'm not 100% up on that.

Lisa: Yes.

Dr Colin: But I was listening to another podcast. It was Ben Greenfield recently.

Lisa: Yes, I like him.

Dr Colin: Who was talking about some of—yes, yes, yes, same—as some of the science around that specifically. And I believe that there might be some science that has come out, I just haven't read it to be able to be up on it to be 100% honest with you.

Lisa: Yes. I mean, I've heard various things and even like getting your hands on the dirt and gardening and how much of a good effect that can have on your body and your mind and your mood and things like that.

Dr Colin: Yes.

Lisa: And I mean, we are in science starting to actually see why is it important to go out and have early morning sunlight and circadian rhythms and all of these sorts of things...

Dr Colin: True, true.

Lisa: ...and connection to the ground and the effects of the medicine, and I don't think we're there yet with all the science. But my take is—on that is yes, go out and spend 10 minutes a day with your hands and the dirt and connect with the ground. And if nothing, the being in nature is definitely going to calm you down and make you feel better.

Dr Colin: 100%.

Lisa: Yes, so that's already, I think—okay, so just looking at some most common running injuries before we sort of wrap up the call. If we can look at like plantar fasciitis and perhaps Achilles and calf muscle injuries and perhaps knees. It's a picture you will cover in a few minutes, isn't it? If we want, the second podcast, Dr Colin.

Dr Colin: Yes. We can do a podcast on each one of those actually.

Lisa: Well, actually, I think I will be getting you on because your knowledge is next level.

Dr Colin: Thank you.

Lisa: So let's talk a little bit about say Achilles.

Dr Colin: Sure.

Lisa: It's one of—it's a very common problem.

Dr Colin: It is. Yes, yes, it really, really is. And Achilles is a difficult one. Again, depending on where things are at and what we know, whether it's insertional, or midportion, there are definitely are two different protocols when it comes to it. So, from the physio side whether you do eccentric loading, which is raising up on two feet, lowering down on one or whether you're doing a different kind of strengthening programme that really is sort of the physio side of that end of it, where I tend to come in on that and where I tend to see a lot of Achilles injuries are people who wind up changing the drop of their shoe too quickly. And so they're used to running in something that's either too low or too high and then make it an abrupt sudden change, or they change their running style too quickly.

So, it's very common to see people who go—who are heel strikers who want to try forefoot running for the first time and if they do it improperly when you load the ground with your heel, I mean, yes, we know that if you overstride braking forces and everything else are really bad for you and smashing your heel into the ground might not be ideal for everybody.

But if you're running on your forefoot, you're striking, your initial contact is with your forefoot, then you touch your heel. Then you push off your forefoot again, right? So, one is heel midfoot toe, one is forefoot heel, forefoot. So, to that end, you're going through a much larger cycle of Achilles loading. And so for some people, especially who—if gene, you were talking about genetics earlier, we know that there is a genetic predisposition for some people, or Achilles issues specifically if you're one of those people, then that can certainly be a bad thing if you do it too quickly.

And so to that end, we talked about the very first thing we do is deload the Achilles. So using things like heel shoe, heel lifts, and footwear, to be able to, for a short period of time, take some of that load off the Achilles, allow it to heal and then gradually reloaded it as they've been working with their physio to be able to gain back strength and mobility and everything else. The one thing that I like to look at everybody who comes to my clinic because I think it's so incredibly important, is their ability to move their ankle appropriately because their calf musculature is flexible enough.

Lisa: Yes.

Dr Colin: And I'll get into trouble there because some people say, ‘It's not coming from your calf, it's coming from your hip'. It can be coming from your hip certainly if you have things that are changing your pelvic tilt, and it's lengthening your hamstring, and it's doing that, and then you're getting the effect of change that comes with it, it's a matter of just looking at it to understand where that change is coming from. But any ankle restriction in your range of motion can make you use your Achilles in a different way, the simplest way for your body to compensate for that is to out-toe and pronate more, well, you're going to get a rotational stress on your Achilles, for some people that's just going to be too much combined with the kind of running programme that they're doing. And so one thing to think about for sure.

Lisa: Wow, this is like, you're a foot specialist, but you also need to have a really good understanding of the whole anatomy of the body really, don't you? Because you have to be a holistic in your approach because, and then this is one of the issues that I have with the medical world in general, now speaking is that they’re so siloed. If you've got a lung problem, you go to the lung specialist, or the pulmonary, if you've got a heart and then the ear, nose and throat are separate, and yet it's to do with your lungs, like, we need to have a holistic ‘Look At It systems’ in the body or the—not even systems, but the entire body, so everybody has to have it.

Dr Colin: Yes.

Lisa: And it's difficult because you have to have a specialised education in feet, you can't be an expert in feet and an expert in hips.

Dr Colin: Yes.

Lisa: But you do need a general education to be able to understand: what the roles of the other therapists or doctors or whatever it is in order to have a good understanding. And I think that holistic approach were possible, into sort of disciplinary communication, is really, really important. Would you agree with it?

Dr Colin: Oh, that's the only way that I work is multi-disciplinary. And so if there's one specialist that thinks that they can fix everything, then that usually makes me want to run away screaming. And because there's just isn't enough flexibility in your thinking to understand that, maybe what you're doing won't be enough for somebody. And again, can't tell you the number of people that come in to say, ‘I've seen my ex-specialists who said, there's nothing else that can be done. We get them back running within six weeks'.

Lisa: Wow.

Dr Colin: You know what I mean? It's only because we were flexible enough in our thinking to be able to say, ‘Yes, we're gonna change this little thing over here. That might be the thing that's going to get you back to what you want to be doing'. So, it’s so...

Lisa: I could go in a rant on that, really. I could go on a rant about the amount of times that people have been told, ‘You can never run again'. I was told I would never run when I broke my back when I was a young lady. And that were wrong, 70,000 kilometres later.

Dr Colin: Yes.

Lisa: If I'd lifted up to so-called experts who, with my mother who had a massive brain aneurysm five years ago and who said that initial, ‘You’ll never have any quality of life again’. She's got massive brain damage. They were wrong. I spent five years rehabilitating her, but they were wrong, and she's completely normal again. So, it's not just accepting—what I think is important to realise is the limitations of your knowledge and saying, ‘Hey, I don't know, I'm at the end of my abilities'. You might have to look somewhere else, or outside the square, or try something else to talk, to so and so.

Dr Colin: Yes.

Lisa: And that's fine. That's good if we get there but not blanket saying, ‘Well, you can never run again because you've got a knee injury.’ The amount of times, amount of runners who have come on doctors said I should never run again because I've got some slight knee problems, and I was like, ‘Really?’

Dr Colin: Yes, no, I agree. So, a case in point in my own life, I have congenital arthritis. That's so bad. I had my first hip reconstruction at 17.

Lisa: Wow.

Dr Colin: That left me with a four-centimetre leg length discrepancy. So I've got some real orthopaedic problems. And was racing mountain bikes at almost the pro-level in Canada in downhill at the time, and wanted to pursue that. And I was told, ‘Never ride a bike again', this kind of stuff. And I'll be doing a half Ironman in Muskoka in July...

Lisa: Wow. I love it.

Dr Colin: ...25 years later.

Lisa: Exactly.

Dr Colin: So, yes. At the end of the day...

Lisa: And if we keep founding way round the problem. Yes.

Dr Colin: Yes, I mean, you know your limits better than somebody else. But I think that there's also a time when you do need to respect the knowledge that someone's done and spent time attaining. But if they'll put aside all of your own expectations and things, then they're not doing you a good service.

Lisa: No, no. And sometimes they're wrong, and they're just not up—what I'm also saying, and we're getting off on a tangent here, but it is a—if your life is different there's definitely a 20-year lag between what's actually the latest in science and what's actually happening in clinical practice.

Dr Colin: Yes, true.

Lisa: And not so much in the area like you have, but saying things like critical care and things like this, it's just so far behind the eight ball because there's so many hoops that they have to jump through in order to get anything changed, that the science can be saying, ‘Hey, this is what you need to be doing'. And they'll be like, ‘Yes, we need another 20 years before we got adopted'.

Dr Colin: Yes, knowledge translation is difficult.

Lisa: Yes, it just seems to be this huge lag, and in some areas of medicine but I've gotten completely off-topic. But I love talking with people that are on the cutting edge of stuff, and I find your knowledge is absolutely next level.

Colin, I think we're gonna have to get you back because we didn't even get to plantar fasciitis and hips and knees, and all the rest of it and...

Dr Colin: I'd love to.

Lisa: Yes, what you're doing... So, before we wrap it up, where can people find out your books and obviously, you've said on Amazon, but give us your websites, and where people can follow you on Instagram and all that sort of good stuff.

Dr Colin: So we're just starting to build out a website called stuffaboutfeet.com. So that's probably the best place to get me right now. You'll be able to see some of the books that are on there, other podcasts that I've done, you'll watch some videos, and then that's going to be built up just more and more and moreover the coming weeks and months.

And through that site, you'll be able to get to me whether it's a personal email or you want to get on the socials or what have you. And so I've been kind of locked away in both the research lab and the clinic office for too many years. And now we're going to get me a bit more online and doing a few more of these things.

Lisa: Yes, and you're so talented at this interviewing and stuff. So it's really easy to be able to share your knowledge and to get it out there. And then you can have much more of a massive impact worldwide rather than just locally, which is fantastic. You know that we can do that now with technology. So I love getting world-leading people on the show and sharing the amazing insights. And you definitely right up there, Colin. So thank you very, very much for sharing your insights today. So stuffaboutfeet.com, was that right? Was that correct? And that you've been listening to Colin Dombrowski.

Colin, any last words that you would like to share with people out there?

Dr Colin: You know, I really hope at the end of the day that you use your knowledge, the best to be able to get out there and do the things that you want to do. And don't put yourself in a box, really understand that you're capable of the things that you think that you are, it's just a matter of figuring out how to do them appropriately.

Lisa: Yes. And getting the right people with the right info.

Dr Colin: Yes.

Lisa: And we've just done that, haven't we? Brilliant. Thank you so much, Colin.

Dr Colin: Thank you.

That's it this week for Pushing The Limits. Be sure to rate, review and share with your friends and head over and visit Lisa and her team at lisatamati.com.

The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional.

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Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova 0

Feb 18, 2021

Aging is a gradual process of cell deterioration, but while it is a natural process, there are ways to hack its biological mechanisms. Certain supplements paired with sirtuin enzymes can lead to better well-being and suppress the effects of aging.

In this episode, Dr Elena Seranova talks about the role of sirtuins in maintaining cell health. She also discusses how several supplements, including NMN and resveratrol, work to enhance the beneficial action of sirtuin.

Listen to this episode to learn how to promote longevity and overall health.

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Here are three reasons why you should listen to the full episode:

Find out how sirtuins play essential roles in promoting longevity.
Learn how NAD influences sirtuin activity and how several compounds can increase NAD levels in the body.
Discover the best methods for taking resveratrol supplements.

Resources

Dr Elena's study on stem cell models of neurodegeneration for studying autophagy
Study on NAD supplementation by Dr Elena's collaborator
Research paper on the benefits of trehalose by Lisa's supervisor

Episode Highlights

[03:24] Elena's Background

Originally a psychologist, Elena ventured into neuroscience through her work on a neurofeedback device for patients with psychological and neurological diseases.
She eventually pursued a master's degree in translational neuroscience and joined a biotech startup.
She continued her studies through a PhD focusing on the molecular pathways of autophagy.

[09:41] Sirtuins and Gene Expression

Sirtuins are enzymes arising from various genes found across multiple species. They play crucial roles in evolution.
Sirtuins assist in epigenetic regulation, where different cells have different active genes.
Events such as taking a sauna or engaging in exercise change the environment of your cells. Evoking changes in gene expression helps you adapt to these conditions.

[19:09] Longevity Impacts of Sirtuins

Sirtuin 1 is heavily involved in repairing DNA damage, while sirtuin 3 contributes towards mitochondrial health.
The enzymes coming from both sirtuin genes require the molecule NAD for proper function.
With insufficient NAD, sirtuin enzymes might be unable to fix DNA and mitochondrial damage sufficiently.

[25:59] NAD Boosters

NR and NMN are two promising energy booster supplements that might boost NAD+ levels.
NMN shows higher bioavailability and more positive effects on aging mice.
Elena herself experienced improved energy levels when she started taking NMN supplements during her PhD years.

[37:05] Resveratrol and Sirtuins

Resveratrol activates sirtuins, allowing them to function.
It works well with NMN — resveratrol handles activation, while NMN provides energy.
To increase the bioavailability of resveratrol, consume the supplement with dairy products or food items with oil.

[40:01] Apigenin, Sirtuins and NADases

Several enzymes compete with sirtuins for NAD. These NADases mean that sirtuins cannot function without a large NAD supply.
Apigenin, which is present in parsley, blocks a certain NADase and leads to increased NAD levels.

7 Powerful Quotes from This Episode

‘We'll be having different sets of genes being activated, and this will be in response to different external stimuli, environmental stimuli, amino acids, even availability of nutrients’.

‘What sirtuins do is they upregulate many physiological processes in order to deal with potential danger’.

‘[Sirtuins] do need a molecule called NAD, nicotinamide adenine dinucleotide, and without this molecule, they cannot perform its functions. And what's happening when we age is unfortunately we do have reduced levels of this molecule as we age’.

‘From anecdotal evidence from myself and people that I know that have supplemented themselves with both, everyone just pretty much mentioned to me that they do like NMN much more than NR and they can see the effect and this is the reason why I ended up supplementing with NMN myself’.

‘So within three, four days, I actually felt a different “different”. I felt different energy levels, I felt an increase in my energy levels and I felt an increase in my focus’.

‘Basically what activates the sirtuins is the resveratrol molecule, but in order for them to function properly, you do need the NMN because this is what they consume in order to function, and so this is why it's such a good synergy’.

‘Besides sirtuins, there are different other enzymes called NADases that also consume NAD and if they do that consistently there is not enough NAD for sirtuins to do their job’.

About Dr Elena

Dr Elena Seranova started her ventures into medicine through psychology. She established her private practice as a wellness centre, where she encountered neurofeedback therapy and decided to pursue neuroscience studies.

She took up her MSc in Translational Neuroscience at the University of Sheffield, followed by a PhD in Stem Cell Biology & Autophagy at the University of Birmingham. Her work focuses on the molecular pathways involved in autophagy.

Dr Elena is also a serial entrepreneur. Aside from her wellness centre, she also co-founded a biotech startup before her PhD studies. She is the founder of NMN Bio, a company focused on NMN and other anti-aging supplements.

To learn more about Dr Elena and her work, reach out through her website.

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To pushing the limits,

Lisa

Full Transcript of The Podcast!

Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com.

Lisa Tamati: Well, hello everyone and welcome back to Pushing the Limits. Super excited to have you again with me. Today I have Dr Elena Seranova, who is a molecular biologist to guest on the show. And really exciting. We’re going to be having Dr Elena on regularly to talk different aspects of longevity and anti-aging. And today we're talking about longevity. We're talking about sirtuin genes. You might be thinking, ‘What the hell are sirtuin genes’? but you're about to find out. And why it's important and what you can do to upregulate and support these genes, these anti-aging genes or longevity genes.

So before we get over to the show, just want to remind you. If you are wanting help with any sort of health journey that you're on, if you want some one on one coaching and please reach out to me at lisa@lisatamati.com. If you're looking for help with gene testing, epigenetics, anything of that nature as we've spoken about before on this podcast, you can also reach out to me there, or check out the programme via our website, at lisatamati.com. Everything in health now is about personalizing everything to your genetics. So that's the nutrition, your timings of the day when you eat when you exercise, what parts of your brain you use the most, what your dominant hormones, your personality traits, because of your genetics, all of these aspects are covered in our epigenetics programme. So I'd love you to go and get that.

And for all you runners out there, come and join us at Running Hot Coaching, that's our online run training system. We'd love to coach you. We have personalized customized training plans specifically made for you for your specific goal, along with side video analysis, and you also get a one on one session with me. So go and check that all out at runninghotcoaching.com. That's all for data today.

I am really stoked to have you back. I hope that 2021 is going well for you, that you've had a good break over the last few weeks. And if you're in the southern hemisphere, you're enjoying our beautiful summer. So without further ado, Dr Elena Seranova over in Dubai.

Well, hi everyone and welcome back to Pushing The Limits. I'm super excited. I'm jumping out of my skin. I have an amazing lady with me, Dr Elena Seranova. Hello Dr Elena, how are you doing?

Dr Elena Seranova: Hello, hello, it's really nice to be here today. Thank you for the invitation!

Lisa: It is super exciting. So Dr Elena is sitting in Dubai, and we're going to be having a really in depth conversation today. And it will get a little bit scientific but hang in there with us people because this is all about longevity and anti-aging and who isn't into that?

So Dr Elena is a molecular biologist. And she's going to be sharing today some really critical information about the sirtuin genes. you’d be going, ‘What the heck is a sirtuin genes and what do they do? And why do I need to know about them?’ But these are really important things.

But before we get into that, the nitty gritty of the science, Dr Elena, can you give us a little bit of background on you and where you've come from? And what you've done in a nutshell, so to speak?

Dr Elena: Absolutely, yes, so I'm actually an interdisciplinary scientist. So I started my studies in the field of psychology. And then I opened my private practice. So that was my first business that grew into a wellness centre and was in operation for five years. I had two branches. That was back in my home country in Greece.

And I ended up working with a neurofeedback device that was basically retraining the nervous system of different patients with psychological and neurological diseases. And this is how I got interested in neuroscience. And I started studying it myself. I took a couple of those online courses. And I realized that this is such an amazing field.

And in order to understand the symptoms that I see my patients, I actually need to understand the proper science behind it.

And when I started digging deeper, I realized that it's actually the genetic component that is the crucial part that produces all the symptoms. So then I found this amazing master's degree in neuroscience and genetics, and specifically in translational neuroscience in the UK. And back in the days, in 2015, the Greek crisis was bad. So I couldn't grow my business as much as I'd like.

So I decided to move to the UK to do this master's degree. And after this, I ended up, co-founded a biotech start-up that also had to do with the biochemical assays that were aimed at elucidating gene to gene regulatory networks.

And with that, I also realized that I'm even more fascinated by the science, and I really want to stay in biotech. And my co-founders were making fun of me because I was the only person in the office not having a PhD. Yes, that was a traumatic experience. And at the same time, they were surprised when I said that I'm leaving the start-up to do my PhD.

Lisa: They shouldn’t have said so.

Dr Elena: Yes, exactly. So yes, this is how I continued my studies. And my research was focused on the molecular pathway of autophagy. And I was using human physiological cellular platforms of neurodegeneration, utilizing human embryonic stem cells and induced pluripotent stem cells to model neurodegeneration, which was very, very interesting.

And I actually have a review in the Journal of molecular biology that got out a few months ago, in April 2020, on the modelling of neurodegenerative diseases and studying autophagy in those models in human pluripotent stem cells. For anyone interested, you can go check it out. It has an open access.

Lisa: We’ll put the link in. Well done. Congratulations, that’s pretty amazing. And that brings me to a point I'll have to have a separate conversation with you about neurodegeneration and what we can do for the elderly. I've got a vested interest in that one. So we'll definitely put that on our calendar because Dr Elena is going to be coming on the show actually quite regularly in the next few months. So we're going to be doing a bit of a series because I think the information that Dr Elena has is just going to be crucial for you guys out there listening. So really, really excited.

But today's subject is all around sirtuin genes. Now these are—I'm going to try and explain it because I've been deep in this research too. So what tipped me down to this path and longevity and anti-aging, obviously, I've been in that space for a while. I listened to Dr David Sinclair on a podcast and subsequently read his book Lifespan, which I recommend everybody go out and buy. It's called Lifespan: How We Age—And Why We Don't Need To.

And Dr David Sinclair is a very, very prominent scientist at Harvard Medical School. And he has his own lab and he’s been studying anti-aging and longevity for decades now. And he was actually the one of the scientists who discovered resveratrol, which we're going to get into today and what resveratrol does, and it's very pertinent to the conversation. But it is also in this book, really giving me an eye opener into what's coming down the pipeline as far as longevity and being able to turn the clock, actually literally back to when you—so, our cells become young.

It sounds almost science fiction-y, some of the stuff that he's talking about that is just around the corner. It is like absolutely amazing stuff that we are going to be able to live longer, healthier lives. And for me, it is about health span, as well as like I obviously want to live long, but most importantly, I want to live healthy till the end. And I think that's probably the priority for everybody. Rather than having the typical degenerative, long, slow, drawn out process.

So anything that I can do to help my friends, my followers, my family live healthier lifespans, I'm into that research. So Doctor Sinclair is an expert on sirtuin genes, this is an area that he studied. And Dr Elena knows all about this. So Dr Elena, can you just tell us, for starters, where do we start on this big subject of longevity genes? And what they do in the body? That might be a good place to start.

Dr Elena: Yes, sure. So sirtuins are enzymes, basically. And it's a group of genes that is quite well conserved across multiple organisms, which means that they play a very important role in evolution and in our biology. And what they basically do is they control the epigenetic regulation in ourselves. And this means that when—in different tissues, there are different genes being activated at a different time. So we'll be having different sets of genes being activated, and this will be in response to different external stimuli, environmental stimuli, amino acids, even availability of nutrients, things like that. And what they really do is they control that all of the important regulatory pathways in the cell are functioning as needed, and they are quite responsive to external stimuli.

So for instance, you mentioned resveratrol, which is a molecule that is found in grapes and in other berries and different plant sources. So, resveratrol is actually found when the plants are stressed. So when there is some sort of either fungal infection in the plants, or there is no water and so on, resveratrol is the molecule that is being secreted. And what's happening is that sirtuins can sense this molecule, and as a result they do get upregulated.

And the reason for this — I guess this evolved from a revolutionary stand point of view is that, so you would have let's say, some small animals running around and consuming different plants, things like that. So the small animals cannot really distinguish consciously between danger, different dangers or lack of foods and things like that. So this process had to somehow be automated. So for this reason, again, resveratrol is like a signal that says to the little animal that there is some sort of danger in the environment. And then what's sirtuins do is they upregulate many physiological processes in order to deal with potential danger.

And there are different stimuli like that in our environment, and we can actually artificially activate sirtuins. So for example, with the use of sauna. We do have this heat shock response, where there is a stress signal from the environment, and then again sirtuins get activated because there is some sort of stressor coming into the body. Another one is exercise. So what happens? And actually not any kind of exercise. But let's say if you're just going for a walk for 20 minutes, you won’t get sirtuin activation. But if you're going for a run, and you start being out of breath, so that your body goes into slight hypoxia. And this is the signal that activates the sirtuin. So for all of the healthy living enthusiasts, don’t just go for a run. Absolutely.

Lisa: So just to recap on that, so this sirtuin genes which code for this enzyme. This enzyme is really important, and we'll get into a little bit more than nuts and bolts of this enzyme, but it does some very important activations on the genome, which is what we want.

Dr Elena: It basically regulates which genes will be switched on and which genes will be switched off. So it allows for a very tight control, for a very tight regulation of the functionality of different genes in the cell.

Lisa: Right. And then so sauna, which produces heat shock proteins, I've just bought a sauna recently for that reason. Yes, yes. Well, I heard about heat shock proteins, what sauna can do, how beneficial it is for so many things. I didn't make the connection to that and sirtuin genes. So that's really something I've learned today.

I did know about the exercise, and this is why like high intensity interval training, in moderation people — not like go and do this every day, please, but in moderation. It has a longevity benefit, has an improved actual VO2 max and endurance. And all of these great cardiovascular benefits is partly in relation to the sirtuin genes.

And just going back to the resveratrol, this is a xenohormesis, isn't it? So a stressor that the body goes, ‘Oh, where our environment—is there's something wrong in our environment. So we need to hunker down and get ready for battle’, rather than going forth and multiplying and everything's easy and happy.

So we want to push and pull in regards to all of these things like exercise, like sauna, like resveratrol, you want times of actually pushing things and in times of recovery, so it's not just going in one direction, is it? It is like balance.

Dr Elena: Definitely. Definitely. And then yes. And then another trigger for the sirtuins phase, caloric restriction. And this again comes from what we just described about the animal being hungry, potentially in the near future. So the sirtuins get activated. So it’s the same when you're on a calorie restriction and you're doing intermittent fasting, you will get this reaction again.

And this is tied up to autophagy as well, which has been activated. So you actually need to be fasted for several hours for autophagy to be activated. And research suggests it could be around 18 to 20 hours or more in humans. So I'm personally trying to do this on a daily basis. I'm having a very narrow window where I consume food probably three, four hours a day. I mean, it's not possible, always, especially when you're traveling around like I do at the moment. It might be challenging because I also want to eat high quality food. So I don’t want to be eating junk at the airport.

Lisa: Pretty hard, isn’t it?

Dr Elena: Yes. I mean, sometimes this actually pushes me to fasting even longer.

Lisa: Great discipline. I can't—I struggle to go over the 16 hour. And I think partly with autophagy—so autophagy, people, this is when the body basically, there is a pathway called mTOR, which we're going to probably do another episode on. And this is a growth regulation pathway where we are actually—if we are activating there's a lot of amino acids, a lot of proteins in the body and a lot of nutrients in the body sort of goes into growth mode. So like bodybuilders want this growth mode for example.

And when you go hypocaloric for a while and you restrict the calorie intake, then the body goes into a state of autophagy, which is where it's basically eating and recycling it's old cells that actually need to be gotten rid of. And these cells are called senescent cells. So these cells are alive, and they're putting out inflammatory chemicals or cytokines, and then not actually replicating, and that causes problems in the body. And as we get older, we eat more senescent cells.

So you don't want to be in a state of starving all the time. That's not what we're saying here. This is why it's intermittent fasting. And you don't have to do this every day, people. I know, I don't. I'm not as disciplined as Elena. But doing this on, I think something like five days may be normal and a couple of days, where it's sort of a longer fasting period. And just giving your body that change. If you go hypocaloric for weeks on end, you're going to down regulate your metabolism. So that's not where we want to go. And then you're going to have nutrient deficiencies and so on from that point of view. What we're trying to get is this seesaw, the body seems to—like in all of the studies that I've done, it seems to like the seesaw, like cycling. It likes going up and down, up and down. And that actually helps it keep its ideal balance, putting it very bluntly and simply.

So autophagy is something that we want. So fasting, mimicking sauna, exercise, all of these things are going to upregulate the sirtuin genes and these sirtuin genes. Now can you tell us—there are seven sirtuin genes in the human genome, can you just go briefly over what one up to seven does?

Dr Elena: Yes, I mean, there are quite a few functions that those genes have. So I don't think we'll have time to go through all of them. The important ones for our subject today for sports and longevity, and so on, is sirtuin 1 for sure, which is a very important protein that can be found both in the nucleus and the cytoplasm. And actually, its expression is different in different kinds of tissues and it also depends on its necessity and its function. And it's actually what we’ve seen is that sirtuin 1 is one of the first genes that would go onto the side of a double stranded DNA break to recover it. So it is heavily involved with DNA repair, very important gene.

And then sirtuin 3 would be the other very important for longevity, which has to do with mitochondrial health and mitochondrial function. So those two, they both are enzymes that in order to function, they do need a molecule called NAD, nicotinamide adenine dinucleotide. And without this molecule, they cannot perform its functions. And what's happening, when we age is unfortunately we do have a reduced levels of this molecule as we age, of NAD. And it just keeps on decreasing and decreasing, basically leading into death but a literal death spiral, where you don't have this beneficial effect of the sirtuin genes repairing your genome, repairing your DNA. And the epigenetic regulation becomes basically loose. So this is what is directing the loss of cellular identity as well. So this is one of the hallmarks of aging, where the cells are losing their identity. And then everything that is happening in the cell, all of the functions, they’re being so tightly regulated. So this is what's happening there.

And then NAD, it's worth mentioning that it exists in two forms and both forms are important. So NAD+, which is the oxidized form and NADH, which is the reduced form. So the reduced form, it's actually something that not many people talk about in the aging space and the supplement space, so they barely know NADH and NAD+. And NADH is actually important for the maintenance of mitochondrial membrane potential. So if you don't have enough NADH, your mitochondrial membrane potential will not be preserved as needed. And this would also lead to decreased mitochondrial function. And decreased mitochondrial function means that you will have a less ATP production and less energy as a result.

And the reason why this is so important for neurodegeneration, as you mentioned previously, because actually, the central nervous system is perhaps the first one that is being affected as we age. So it's very important. And the reason for this is that the postmitotic neurons that we have in the brain, they are heavily relying on massive ATP production in order to function.

Lisa: So let's stop there, Elena because your brain is so big. We might have lost a few people on the way there, we might have to backtrack a little bit. So NAD, nicotinamide adenine dinucleotide plus or NADH. So is this a little bit like oxidized, like vitamin C oxidizes and then reduces, oxidizes and reduces. And electrons can be donated backwards and forwards. Is that the same thing, sort of pathways?

Dr Elena: Yes, yes. Yes. That’s right. So NADH gains two electrons.

Lisa: And that is recycled through?

Dr Elena: Yes, this is happening through electron transport chain in the mitochondria. And we need both of those molecules in order to maintain proper cellular function. And so this would bring us to our next subject, which is what we can do in order to fix this decline of NAD.

Lisa: Before we go there, let’s just hang on a tiny bit on this NAD, because — so NAD, I know Dr David Sinclair said, arguably the most important molecule. So people, note this name, NAD, NAD+, or NADH. This is the most important molecule in our body next to ATP, and ATP is our energy production. So without energy we’re dead in 30 seconds, and without NAD, we're dead in 30 seconds as well. So either or we're both pretty much up the creek if we don't have either.

As we age, the NAD levels go down. And one of the things that regulates the NAD, or needs NAD sorry, is the sirtuin genes to do their job of DNA repair, is one of their jobs. There are many jobs that it does. And if the NAD is being used by the sirtuin genes to repair DNA, then it's not doing its other jobs. And as we get older, like we have something like 2 trillion DNA breaks, it can be wrong, per minute or something ridiculous. Dr Sinclair said, every minute in our body — so, these enzymes are running around trillions of times in our body doing the DNA repair. And also we need to replicate ourselves and do all of this sort of work.

So if the sirtuin enzymes are busy doing one thing, they're not doing another thing. So we want to have more of these enzymes available for all of these jobs. And especially as we get older, and we need more support. So that's just a bit of how that sort of explained what the NAD is.

Now, we should go on to the next part of the equation. So like there was an NAD salvage pathway, the body needs grams of it every day and we don't necessarily just get it by our food. But there is NAD boosters. What can we do to increase our NAD levels in the body?

Dr Elena: Yes, so yes, this is exactly where energy booster supplements come in. And there are various supplements out there. and recent evidence points towards two particular molecules that are being researched. One is an NR, nicotinamide riboside and then the second one is NMN, which is nicotinamide mononucleotide.

So now the NR molecule, in order to boost the NAD levels it needs to be converted into NMN first. And for this reason, scientists are focusing predominantly on NM. And I would say now there is increased interest in the NMN molecule at the moment because it looks like it has increased bioavailability, is being absorbed better. And in tests in mice, it does have a better effect on NR in terms of boosting NAD, but also in terms of the—in terms of improving the phenotype of aging mice with different studies that we've seen that have come out in the past couple of years, from gene expression to energy metabolism, lipid metabolism, insulin sensitivity. A bunch of other markers being improved in my supplemented with NMN. And I have to be honest with you I haven't looked in depth into the research for NR, however the evidence from NMN studies so far is quite overwhelming for me.

Lisa: Exactly, wonderful with all the research, too.

Dr Elena: Yes. I mean we would need to have more comparisons but from anecdotal evidence from myself and people that I know that have supplemented themselves with both, everyone just pretty much mentions to me that they do like NMN much more than NR, and they can see the effect. And this is the reason why I ended up supplementing with NMN myself.

So basically, I started studying NAD biology in block during my PhD. And unfortunately, my research paper is not published yet, so I won't be able to share that out. Perhaps next year hopefully I'll be able to share my data with you.

There is a paper from our collaborators lab though that is on bio archive already. And it's from Viktor Korolchuk in Newcastle. And they showed there how basically functional autophagy can maintain NADH pools, which is quite an interesting paper. And it does intertwine a bit with my work. But unfortunately, I can't share right now.

Lisa: Yes, you have to keep zip right now until it's published. So we can link to the bio archive, the one you mentioned there, at least, do some research and also I’ll also link to Dr David Sinclair's work, in his book, obviously. Because it does put it in in a way that people can understand, which is really, really important.

Okay, so NMN, nicotinamide mononucleotide is one of the in NAD boosters, and we need the in NAD to...

Dr Elena: Yes. And it's the only direct precursor of NAD. So this is the beauty of it. So from NMN, it converts straight away to NAD. So this is why it has such an enhanced bioavailability. This is why it has those effects because NAD is quite a large molecule by itself. So it's actually hard to—if you supplement orally with NAD. The absorption of the—it will not be high, because of how big the molecule is. So this is why it's called dinucleotide because it has two nucleotides that would need to penetrate the cell. But NMN is a mono nucleotide. And this is why it absorbs better

Lisa: It's actually made there—it's put together in the cell. So the nicotinamide mononucleotide enters through the membrane into the cell, from what I'm understanding, and then it becomes a dinucleotide. So it's a phosphorus molecule, I think or something that's added to the NMN. And then it's an NAD.

Dr Elena: So yes, so basically it's NMN is a phosphorylated NR molecule basically.

Lisa: Okay, phosphorylated NR molecule, okay, and then when it goes to NAD...

Dr Elena: And that’s the reason why NMN is actually a bit more expensive than other supplements. Because in comparison to other supplements that are just, let's say, plant extracts or something like this, there is quite a lot of biology implicated in the production of NMN. So there are several steps it would need to go through. And it's quite complex and laborious to produce. And this is why it's a bit higher in terms of price.

But from my personal experience again, so I started supplementing with NMN over a year ago, while I was still doing my PhD. And at that point—when I found NMN, I already had a burnout. So, which is something that a lot of PhD students experience and my project was quite, quite challenging. And human embryonic stem cells require quite a lot of cell culture in order to just survive, let alone to expand them and do experiments on them.

So yes, at some point during my PhD, I literally was doing 18 hours, from 6am till midnight. With eight or ten hours of cell culture during that day, let alone the experiments I had to do. So yes, quite challenging. However, it was a priceless experience. I learned a lot. And I think that it was definitely worth it.

So yes, back in the day, so while I was experiencing this burnout, I found out about NMN. And I thought to give it a go. And it was basically amazing the fact because I've been supplementing with different supplements for the past 15 years or so. And I'm a biohacker myself.

Lisa: Yes, yes. Like me.

Dr Elena: I transfer with different supplements and stuff. And this was the supplement that I felt the effect of within a few days of taking it and I've never experienced that before with any other supplements. So within three, four days, I actually felt different. I felt the different energy levels. I felt an increase in my energy levels and I felt an increase in my focus. And I remember my partner calling me at some point in the evening at 8 or 9pm, something like that. And we were talking on the phone and he just said ‘Oh, so you're not tired yet’. And I’m like, ‘No, I'm not tired. I actually feel great’.

Lisa: ‘This stuff's working’.

Dr Elena: Absolutely. Yes. And this is how my current business was born. And this is how NMN Bio was born. And I was so excited to actually have a product in the market that is pure, potent and I know that it is what it is. And because I have been struggling to find a good supplier of NMN for quite some time.

Lisa: Tell me about it.

Dr Elena: Yes, because of its price, I think that there are quite a lot of opportunistic companies out there that just white label the NMN powder, and they don't even have a certificate of analysis and you don't even know what's in there and things like that. And they just totally diluted with niacin or something else.

Lisa: Exactly. Yes, this is a danger and this is why having a significant analysis and having it scientifically backed in every batch tested and stuff is really important. I've been on—prior to meeting Dr Elena—I've been on in NMN for maybe five, six months now. And I've had my mom and my brother on it and my husband on it. But I had to go through, jump through all of these loops to get it out of America. Get it sent to someone there. Get it shipped over here and it's not been available down the scene of the world. And finding a reputable source is absolutely key with this molecule.

I remember David Sinclair saying, when you do get your NMN do keep it in a cool, dry place. So don't stick it in a hot place under the sun somewhere. Ideally, probably in the fridge if you can, to give it an extended shelf life and for it to do its job properly.

So you've founded a company NMN Bio, at the UK, and I'm really excited to be working with Dr Elena and I'm going to be importing it down to Australasia.

Dr Elena: I'm super excited about this too.

Lisa: Yes, me too. Like it's just super exciting for me. Because I'm spending a fortune a month, giving this to my family anyway. And I could never test what I was doing. And now I have a place where I can trust that it's coming from a good source.

So nicotinamide mononucleotide is the one aspect but that's not the end of it all. Is it though? That's not—so resveratrol we mentioned before. This work in combination—and on that point, it should be trans-resveratrol that you take, if you're taking resveratrol with it.

Dr Elena: Yes, absolutely.

Lisa: And we don't have this yet in the cater of products. But this is in the pipeline, isn't it, Dr Elena?

Dr Elena: Absolutely. Yes, this is coming in 2021. Super excited about it. Hopefully we'll have it on the market in the next few months.

Lisa: In the next months.

And but resveratrol, trans-resveratrol you want to be taking that in combination with nicotinamide mononucleotide. So an analogy that Dr Sinclair said was resveratrol is like the accelerator pedal and nicotinamide is the fuel. I think that’s the way around.

Dr Elena: Yes, absolutely. That's correct, because basically what activates the sirtuin is the resveratrol molecule. But in order for them to function properly, you do need the NMN because this is what they consume in order to function. And so this is why it's such a good synergy. And as you said, trans-resveratrol is absorbed much more. And also in order to increase the bioavailability of resveratrol, it's good to take it with some sort of full fat dairy. So for instance, a yogurt. David Sinclair says that he does take it in the morning with a full fat yogurt.

Lisa: With some fat, yes..

Dr Elena: In fats, or you could you could do some cheese, probably. I do yogurt as well.

Lisa: Does it have to be dairy? I've been taking it with oil, is that okay?

Dr Elena: Yes, this could work as well. So yes, absolutely. There are a few people doing olive oil for this type.

Lisa: So it just needs a fat in order for it to be bioavailable, because it’s a dry powder. And so the oil in the fat helps. Because it's a very insoluble molecule.

Dr Elena: And then what I do for my personal anti-aging cocktail...

Lisa: Which is obviously working, because Dr Elena is actually 110 years old.

Dr Elena: No, just 32.

Lisa: She’s just 32 but looks like—honestly, I thought, seriously 32? I would have thought you were 22. So something's working. The good diet. It can't be that overworked because you've been definitely overworking for the past few years. And this is obviously helping.

And I'm 52. So I'm old enough to be your mom. And I'm definitely super excited about anything that's coming down the pathway that's going to slow down the degeneration. Because over the years, and after smashing the crap out of my body, I've definitely got some repair work to do. And my mom is 79 years old, she's in the corner over there, taking her NMN as we speak, and her resveratrol, along with their hemp seed oil and all the other supplements and a big green smoothie of broccoli juice. So she's like going, ‘ugh’, it'd be quite funny for you to see her face right now.

Dr Elena: You should also add apigenin to her cocktails. So, this is another molecule which is very interesting. And perhaps in a later podcast, we can also talk about a couple of different things that have to do with raising your NAD levels in different ways. So, basically, what happens, besides sirtuins, there are different other enzymes called NADases that also consume NAD. And if they do that, consistently, there is not enough NAD for sirtuins to do their job.

So such enzymes are called parks, which are activated when there are some stress signals in the body. So, for instance, one such signals when let's say your mitochondria are going bad and there is some sort of stress related to mitochondrial function, you will get a secretion of cytochrome c from mitochondria. And then as a result, you will get some sort of activation of the park enzymes and they also consume NAD.

Another NADase is CD38. So, this is an enzyme that is activated when there is increased inflammation in the body. So, as we age, CD38 levels increase. And what has been demonstrated very beautifully in a recent study in mice was that CD38 actually controls the functions of sirtuin 3 in an NAD dependent manner. Because they did quite an elegant experiment, where they did have CD38 knockout mice, and the wild type mice or regular mice. And in the CD38 knockout mice the levels of sirtuin are two and a half times higher. And then when they put a saturating amount of NAD in the wild type mice, what happened is basically the function of sirtuin is also increased. And it was similar with the function of surgeries in CD38 knockout mice. So this means that if CD38 is absent, then sirtuin3 in this instance is upregulated and is working much more. But when CD38 is present, it consumes all of NAD and then there is not enough NAD for sirtuins.

Lisa: And this is so this is why we need a bigger pool of NAD, basically for all of these problems as we age.

Dr Elena: So this is one point and then the second point I was going to do there is that apigenin, so the supplement that I mentioned to you, which is actually present in parsley and predominantly in dried parsley. So you can actually get it for cheap.

Lisa: Yes.

Dr Elena: Have a teaspoon of dried parsley every day. So apigenin is a molecule that actually blocks CD38. So this means that it can also increase the levels of your NAD and make it available for your sirtuins.

Lisa: Wow. I'm off to get some parsley. I just ripped my parsley plants out of the garden. Bugger. I will get seeds, so I'll have to plant some more. And you do need to dry it in order for it to intensify.

Dr Elena: If you dry it, it will have even apigenin. So, the bioavailability increases somehow, I'm not entirely sure of the mechanism. But yes, dried parsley.

Lisa: Yes. Sorry. There's a noise in the background with my mum washing out a broccoli.

Dr Elena: No worries.

Lisa: Yes, yes, yes, this is my podcast life. Real.

So activated immune cells. So like I've had an infection for the last couple of weeks. So I've been under a hell of a lot of stress in the last year, like really—losing my father and so on, a hell of a lot of stress. And the day before Christmas, I stopped working and I started to relax and my immune system then went, ‘Okay, cortisol levels are now going down. We're going to make you sick. We’re going to do some repair work’.

Dr Elena: That’s how it’s usually done.

Lisa: Yes, yes. That's what happens when you relax. So my whole Christmas period was spent with a head cold and a chest cold. Now, when my immune system is activated like that, I'm going to need a lot more NAD because of this in NADases. You call them, NADases? And the CD38 would have been one of those things that was probably more active when I was sick. Would that be right? Okay, so we need to increase that in order to help our immune system.

So does this—random thought—does this help with other autoimmune diseases as well? Like, does it help deep down regulate some of the inflammatory pathways?

Dr Elena: I don't know, this is not my area of expertise. Wouldn’t be able to comment on top of my head on this.

Lisa: Yes, just me connecting the dots going—that would make sense but okay. So all right, so we've covered quite a lot of ground today. And I think we'll probably wrap it up there, Dr Elena. And we'll go on to mTOR and autophagy and other things in subsequent podcasts, and so on.

So we're going to put all the links. If you guys want to get some NMN, and in a few months, we will have resveratrol as well. I'm going to put the links in the show notes to the new website. And we're going to be importing it down to here to New Zealand and Australasia. And I'm really excited about that. Because there is one other company that has it here and it's not got any certificate of analysis, there's no sort of thing. So you want to make sure that you know where you're getting this information from all your supplements from, and you want to know who's behind it.

So I'm really, really excited about working with your Dr Elena. I think this is brilliant. I know we've got a whole lot of products that are in the pipeline that are going to be coming down in the next year or so. Other things—so we will be covering those in future episodes. Things like, I don't know epistane...

Dr Elena: We should definitely talk about senescent cells and what we can do in order to combat them. And then of course, the subject of my PhD, which was around autophagy. So, this is definitely a very nice subject for discussion, because as you mentioned, mTOR is not something that you want to mess with on a regular basis. And actually, the good news are that there is the mTOR- dependent activation of autophagy and mTOR independent activation of autophagy. So my PhD supervisor was the one that discovered during his PhD probably 20 years ago, 15 years ago, the mTOR- independent regulation of autophagy and different molecules that value also can work and activate autophagy in an mTOR-independent manner. So one such molecule is already on the market as a natural sweetener. It's called trehalose.

Lisa: Trehalose.

Dr Elena: If you want to supplement your...

Lisa: How do you spell that?

Dr Elena: Trehalose. T-R-E-H-A-L-O-S-E. This is what I use for my coffee.

Lisa: Oh, trehalose. So that will help you increase your autophagy?

Dr Elena: Trehalose has been shown to activate autophagy in an mTOR-independent manner. Yes.

Lisa: Wow. So I don't need to starve myself in order to activate...

Dr Elena: I mean, there is not that much data in humans yet on this particular molecule, to be honest. I actually don't know what is the dose that you would need to have this effect, but I still prefer it over sugar.

Lisa: Yes, absolutely. And anything that supports that pathway anyway and getting rid of these senescent cells. So senescent cells just for those wondering what the hell we're talking about. Senescent cells are basically cells that are still alive, but they're no longer replicating. They're not doing the job properly. And they're sending out inflammatory signals into the body. So they attract cytokines that cause inflammatory responses.

And so what we want to do is we want to knock these cells off them to have their autophagy, meaning their cell death. And when we recycle the parts of the cells for the new job, and that's what we want to happen. As we get older, we get more and more senescent cells and there's actually literally ways our body down and stops and increases inflammation and causes a lot of the effects of aging, if you like. So that's definitely a subject for next time.

But Dr Elena, you've been fabulous today. Thank you so much for the work you do, for the patient you bring to the project. I'm super excited about our collaboration and helping lots of people stay younger for longer. I think that will be.

Dr Elena: Absolutely, that’s the goal.

Lisa: Yes, absolutely. Have a wonderful evening because it’s around midnight in Dubai. So thank you very much for staying up late for me over in Dubai. It's probably too much.

Dr Elena: My pleasure.

Lisa: And we'll see you again soon. Thanks Dr Elena.

Dr Elena: Okay, thank you. Bye bye.

That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends. And head over and visit Lisa and her team at lisatamati.com.

Download this Episode

Breathwork - The key to Better Health with James Nestor 0

Jan 28, 2021

Every day, we spend an average of 20,000 breaths with 11,000 litres of air, primarily made with subconscious effort. If you want better health, changing your breathing technique probably isn’t the first option that comes to mind. We don’t even think about it; we don’t pay attention to how we do it. But it turns out that how you breathe has far-reaching effects on many aspects of human health. Discovering what it means to breathe correctly is crucial for greater wellness.

In this episode, author and journalist, James Nestor, joins us in seeking to unlock a person’s full breathing potential. He discusses the myriad of health benefits controlled respiration can provide. You’ll also learn how industrialisation made it harder to breathe correctly and how various exercises can improve your respiration.

Listen to this episode to discover simple methods to maximise the benefits of each breath you take.

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Here are three reasons why you should listen to the full episode:

Discover how carbon dioxide is necessary for getting enough oxygen in your body.
Learn how soft foods and bottle feeding during childhood can impact your health as an adult.
Understand how oral exercises and breathing practices can significantly improve your wellbeing.

Resources

DEEP: Freediving, Renegade Science, and What the Ocean Tells Us About Ourselves by James Nestor
Breath: The New Science of a Lost Art by James Nestor
Wim Hof Method
James Nestor’s website

Episode Highlights

[04:03] How James Got into Breathing

James is a journalist who once covered a world freediving championship in Greece.
Despite being a swimmer and bodysurfer himself, he was astounded by participants who can dive 300 to 400 feet in a single breath.
Upon returning to San Francisco, James decided to write a book about freediving. His research exposed him to the art of breathing and its importance to wellbeing.
He learned that improper breathing is damaging to the body.

[10:29] The Physiology of Breathing

Contrary to widespread knowledge, it’s possible to have too much oxygen and not enough carbon dioxide in the body. However, it is essential to have a balance between these two.
Many standard breathing methods deplete carbon dioxide levels, leading to lower oxygen saturation and more unsatisfactory performance.
A study found that by holding their breath comfortably for 25 seconds, 85% of the athletes will not have a breathing dysfunction.
Instead of compensating, learning proper breathing techniques can increase your bodily tolerance for carbon dioxide.
Listen to the full episode to learn more about the process of breathing!

[19:57] Basic Breathing Techniques

Most people breathe faster than the optimal rate without realising that many of their health problems come from their breathing rate.
The point of breathing exercises is to acclimate your body to breathe through the nose without thinking about it.
Slower breaths while maintaining the same volume of air can increase efficiency by 35%.
Transitioning to slower breathing will temporarily reduce performance, but you will eventually see improvements as your body acclimates.

[27:11] Nasal Breathing

Listen to the full episode for James’ points on running and breathing!
Nasal breathing leads up to 20% more oxygen absorption compared to mouth breathing, all else being equal.
Nitric oxide is a potent vasodilator that increases blood circulation. Nasal breathing increases nitric oxide concentrations six times more than mouth breathing.
Breathing through the nose is more effective in defending your body against viruses than any other form of breathing.

[38:36] Why Aren’t Breathing Interventions More Popular?

There’s not a lot of money that can come from breathing interventions. Hence, the development of this alternative practice isn’t promoted widely.
That said, James believes that alternative medicine isn’t always the answer. Conventional Western medicine is still crucial for many health interventions.

[41:38] How Modern Diets Changed the Way We Breathe

In antiquity, people always had perfectly straight teeth and larger mouths.
The introduction of industrialised food removed the need for a larger jaw. Evolution drove the shrinking of the human jaw, so more people have crooked teeth or impacted wisdom teeth.
Smaller oral cavities also made breathing more difficult, and the incidence of upper airway resistance syndrome rose.

[44:24] Childhood Feeding

Improper oral posture can root from habitually breathing through the mouth.
When we were younger, chewing was essential. The introduction of baby food prevented infants from performing the right chewing exercises.
Breastfeeding changes the face structure and promotes more efficient breathing.
Children need to eat hard foods to develop a proper jaw and airway.

[48:20] Oral Exercises

Even adults can see improvements in their breathing efficiency by doing basic oral exercises.
After a year of oral exercises, James was able to improve his airway size by around 15% to 20%.
Palate expanders are an option for people who need them. However, oropharyngeal exercises and myofunctional therapy are easier and more effective methods for improving your breathing.

[54:33] Relaxation through Breathing

Slow, focused breathing activates the parasympathetic nervous system, leading to greater relaxation.
Doing breathing exercises several times a day will immensely help you cope better with stress.
Listen to the full episode to learn more about how slow light breathing diaphragmatically stimulates the parasympathetic nervous system and the vagus nerve.

[59:14] Hormetic Stress

The quickest way to reduce stress is to breathe. It is all about working your respiratory system and working out your stress.
James suggests starting with the foundations of nasal breathing, slow breathing and awareness.
Similar to exercising at the gym, breathing exercises promote hormetic stress. At moderate amounts, hormetic stress is beneficial to human health.
Listen to the full episode to learn more about the Wim Hof Breathing Method!

7 Powerful Quotes from this Episode

‘By mastering this sort of breathing, we can not only dive deep, but we can heat ourselves up, heal ourselves, and do so many other things’.

‘Scientific papers were published about this 115 years ago, showing very clearly that you need a balance of carbon dioxide and oxygen to operate effectively and efficiently. When we breathe too much, we can offload too much CO2, which actually makes it harder for us to bring oxygen throughout the body’.

‘That slower breath with that pressure allows us to gain 20% more oxygen breathing through our nose than equivalent breaths through our mouth.”

‘I think our bodies are the most powerful pharmacists on the planet and that’s been shown, so why not try to focus on your body and health a little bit’?

‘By having a smaller mouth, you have less room to breathe. And this is one of the main reasons so many of us struggle to breathe’.

‘Start slow, start low. See what your body can naturally do. If after six months, you’re like, ‘I’m still not, this isn’t working’, go see someone and take it from there’.

‘I talked to dozens and dozens of people who have fundamentally transformed themselves through nothing more than breathing. I want to mention it again. I’m not promising this is going to work for everyone, for everything, but it needs to be considered as a foundation to health’.

About James

James Nestor is a journalist and bestselling author. He has contributed to many newspapers and publications such as The New York Times and Scientific American.

His first book, DEEP: Freediving, Renegade Science, and What the Ocean Tells Us about Ourselves, took inspiration from his journalistic coverage of a world freediving championship.

James also authored Breath: The New Science of a Lost Art where he combines thousand-year histories with modern research to shed light on proper breathing. His investigations have revolutionised the conventional understanding of breathing and have helped many people live healthier lives.

His other projects include speaking engagements for institutions, radio and television shows, and collaborations for scientific research and communication.

Learn more about James Nestor and his work on diving and breathing by visiting his website.

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For more episode updates, visit my website. You may also tune in on Apple Podcasts.

To pushing the limits,

Lisa

Full Transcript Of The Podcast!

Welcome to Pushing the Limits, the show that helps you reach your full potential with your host, Lisa Tamati. Brought to you by lisatamati.com.

Lisa Tamati: Well, hi, everyone. Welcome back to Pushing the Limits in this new year. I hope you're enjoying yourself. You've had a good break over the holidays, and I have a fantastic guest today. Wow, this guy is insane. So his name is James Nestor, and he is an author, New York Times best selling author, Wall Street Journal best selling author, London Times New York Times bestselling author of a book called Breathe. So it's all about breathing. You might think, how the hell do you write a book on breathing. But I tell you, this is going to be a really exciting interview, and you're going to learn so much that you wish you'd been taught years ago.

He's also the author of Deep, another best selling book that he did on freediving. And he's a filmmaker and science writer for many of the science magazines. Now in this book Breathe. He explores the million year long history of how the human species has lost the ability to breathe properly. And why we're suffering from a laundry list of maladies from snoring to sleep apnea to asthma to autoimmune diseases and allergies. And in this, on this journey in this book, which was absolutely fascinating. He travels the world and spends a decade in the attempt to figure out what went wrong and how do—we fix it.

And, you know, the links that the sky week two—for his research has just absolutely next level. I really enjoyed doing this interview with James. He's an incredible person. And just so very, very interesting. So I hope you enjoy the show. Before we head over to speak with James in San Francisco, just like to remind you to do a rating and review if you came for the show. This is a labour of love. And it really really helps the show get out there if you can give us a rating and review, either on iTunes or wherever you're listening to this podcast. Or if you can't work it out, just send me an email with it. And we'll gladly receive those as well.

And if you want to reach out to me if you've got any ideas for podcasts, or people that you would like to see on here, or if you have a question, health question, if you want help with health journey, health optimisation, epigenetics, run coaching, that's our day job. That's what we do for a living. And that's what we are passionate about. And that's what we love. So if you're having trouble with a tricky health issue, if you wanting high-performance, if you're wanting to do that next ultramarathon or first run your first five-kilometer race, whatever the case may be, please reach out to us, lisa@lisatamati.com. And you can find all our programs also on that website, as well as this podcast and lots of other goodies. So I hope you enjoy this interview with James Nestor. Over to the show now and thanks for listening.

Lisa: Well, hi everyone and welcome back to Pushing the Limits. It's fantastic to have you with me and I am jumping out of my skin for excitement today because I have someone that I've been just so looking forward to interviewing. An amazing author, James Nestor, who is going to be sharing his research and his book, which is really a game-changer. Breathe is the name of the book. And James is coming to us all the way from San Francisco today. So welcome to the show, James. Fabulous to have you.

James Nestor: Thank you for having me.

Lisa: So James, can you just give us a bit of a background into your—who you are in your background? And how the heck did you end up writing a book about breathing? And why do we need to know about it?

James: So I'm a journalist, and I write for science magazines and outdoor magazines. I've been doing that for years and years and years. And I think the real jumping off point for me was when I was sent out to go to Greece to write about the world freediving championship. And even though I've spent my life near the ocean, I'm a surfer. I'm a swimmer and body surfer, all that, I had never really spent too much time under the ocean. And I had never seen anyone freedive before because the water is very cloudy here on the West Coast. There's not a lot of places to do this. So I remember going out in this boat, it was the first day of the competition and just watching these people take a single breath and go down 300, 400 feet on a single dive there. And come back four minutes later and—just it was like they we're answering emails just like.

Okay, next up, back for lunch. It was what the hell is going on here? I had understood that this was absolutely impossible. And yet here these people vary sizes, various forms - big, tall, large, small, all that - that had mastered this thing. And I got to be friends with a few of them who took me into this other side of freediving outside of the competitive freediving, which I just thought was pretty insane. And they allowed me to understand free diving as this meditation. And of course, breathing is at the core of this meditation. And by mastering the sort of breathing we can not only dive deep, but we can heat ourselves up, heal ourselves and do so many other things.

Lisa: Wow, so that was the jumping off point in, for those interested. Yeah, I've taken an interest in freediving too. And my gosh, what they do is pretty next level, insane. I don't think I'm crazy enough to really have a go at it. To be fair, but absolute admiration for what they do and how they do it, in—the everything that they have to overcome. But okay, so if we just jump in now, the into—how does we know? What can we learn from these free divers and other traditional breathing techniques? And why is it important for the everyday person to be understanding how the breath works in the physiology, which we'll get into which I found absolutely mind blowing and thought, why is nobody told me this? And why did—why does, why should someone listening to this actually be interested?

James: So the free divers told me that the only way to hold your breath is to master this art of breathing. And it was also something interesting to see all of these different people. And they all had these enormous chest, they had expanded their lung capacity. Some people double the average adult lung capacity by forcing. Well, they were not born this way. So it made me think about how malleable the body is depending on what inputs we give to it. And so I got back to San Francisco, and I wrote another book that featured freedivers. But in the back of my mind, that book was called Deep. And it looks at the human connection from the very surface to the very bottom of the deepest sea, magnetoreception echolocation all that.

But as I was researching that book, and writing, I just kept finding more and more information about breathing, about how so many of us in the West, including in the medical world view breathing as just this binary thing. As long as we were breathing, we're healthy, and we're alive. When you're not breathing, that's bad, your dad or you have a serious problem. But that is such the wrong way of looking at this. It's like saying, as long as you are eating, you're getting food, you're getting nutrients. But it's what you eat. That's so important. And it's how you breathe. That's so important.

So I was lucky enough to then meet a bunch of leading experts in this field who have been studying this stuff for decades, even publishing in these weird scientific journals. No one's been reading their stuff. I thought, why the hell hasn't anyone told me this? Like, I'm middle aged, I've been mouth breathing, through most of my life. I've been whenever I was working out or surfing, I'm just thinking I'm getting more oxygen in. And this is so damaging to the body, and no one was talking about it.

So this book took me so long, because I couldn't understand why some researchers on one side were saying how you breathe has no effect on your asthma, has no effect on your body, on your brain. And this other side was saying they're 100% wrong. Here's all the data. So it was going through all that and weeding through all that that took me a while. But I think at the end, I finally found the truth behind all of this.

Lisa: He certainly did. And the book is such a deep deep dive like you know, and I've been talking to some friends about you know, reading this book and, and everything. How can you have a whole book on breathing? And I'm like, you have no idea. You could probably write 10 books on breathing and it's so powerful. And as an athlete I've, you know, I was just saying to you prior to the recording, I've spent my entire life as an asthmatic since I was two years old. I have a very small lung capacity. I have a low VO2 max, despite that I decided to become an endurance athlete. Go figure that one out, got some mental issues, obviously.

But I'd spent my entire athletic career breathing in my mouth in places like Death Valley, in the Sahara, in the Himalayas, and altitude, and you know, freezing cold temperatures. And all of the problems that that brought and so this book has been a life-changing thing for me personally. Unfortunately, I'm no longer a competitive athlete bagger. You know, like I didn't get the memo back then. But now training hundreds of athletes. Wow, I can start to influence them and change them and are already started to adopt some of the information into the programs that we're using. So super powerful information, and in really important. So, okay, now let's go into a little bit—the physiology of breath because we sort of think if I take deep breaths, and breathe often in faster, if I'm running, then I'm going along. I'm getting as much oxygen as my body can get. Why is that completely upside down?

James: That is upside down. And it's so counterintuitive. It took me months to get my head around this, even though we've known these scientific papers were published on this 115 years ago, showing very clearly that you need a balance of carbon dioxide and oxygen to operate effectively and efficiently. And when we breathe too much, we can offload too much CO2, which actually makes it harder for us to bring oxygen throughout the body.

If you don't believe me right now, you can breathe 20 or 30, heavy breaths. You might feel some tingling in your fingers or some lightness in your head. This is not from an increase of oxygen to these areas, but a decrease of circulation.

Lisa: Wow.

James: Because you need a balance of CO2, for circulation, for vasodilation. This is—it is integral to providing blood and nutrients to our body. And for some reason, as Westerners we just think more is better, more is always more. That is not the way of the proper way of thinking about this when you talk about breathing, you want to breathe as closely in line with your metabolic needs as possible. Why would you?

It's like being in a car. Why would you be revving the motor? Everywhere you're going, I had a stop sign just revving the motor. When you were over breathing. That's exactly what you're doing. You're causing a bunch of wear and tear on your heart on your vascular system. And you're sending stress in those—to your mind. People like you are very strong willed and we'll fight through it right you'll just keep going you're in pain, I don't care. I'm gonna finish this race. I'm gonna make it happen. Compensation is different than health. Oh, and and so this is why so many professional athletes, they'll be really good for a few years. The minute they stopped, diabetes, chronic health problems. Our body..

Lisa: Thyroid, diabetes, metabolic problems. Yeah, like no hell, you've spent your life being a disciplined athlete. I'm struggling with hypothyroid, for example, and high blood sugars. And I'm lean and I'm, you know, it's like what the heck. Like, wow. And I hope through the breathing in some of the other stuff that I'm doing that I can remove some of the damage because you're because it is so counterintuitive. So that carbon dioxide there was a real mind bender for me, because I've always understood carbon dioxide as a negative thing. You know, we want to breathe it out. We want to get it out of the system. That's the end result of you know, what do you call it the electron chain in the ATP production, and we're producing this carbon dioxide, we're gonna give it out.

And that's not the case, isn't it? It's a controller of the acidity in the blood is something that we want to train, our chemoreceptors need to be trained in order to be able to tolerate more carbon dioxide. So this just dive into the winds a little bit on the actual physiology that I've just touched on the air so that we can actually get to the bottom of this carbon dioxide, your mind bender, really.

James: So when we take breath in, it enters into our lungs and the bronchioles, to these little air sacs, the alveoli, and from there it goes through various layers and enters into red blood cells. The vast majority of oxygen enters into red blood. So there's some free floating but not much. So in those red blood cells or something like 270 million hemoglobin, and so then it enters into this hemoglobin. And it's, you know, it's funny, why would when we're working out, why would we get more oxygen in one area than another? So CO2 is the signaling molecule. So where oxygen is going to detach is an areas where there is CO2, and oxygen isn't going to attach otherwise. So you need this healthy balance of CO2, we have 100 times more CO2 in our bodies than we do oxygen.

Lisa: Wow.

James: Okay, so this is this very carefully controlled system that needs to be in balance, and our bodies are so wonderful at keeping us alive. So when we become imbalanced, all these other things happen. If we become too acidic, we'll learn to breathe more, right? We’ll trigger that if we become too alkaline, our kidneys will release bicarbonate. So all of this is incredible and so important.

Compensation, different than health. We can compensate for a very long time. Imagine you can live maybe 40 years eating garbage crap food eating Fritos. That doesn't mean you're healthy. No offense to Fritos. Delicious, absolutely delicious. But, you know, it doesn't mean you're healthy. So…

Lisa: Yeah.

James: ...the reason why you have to understand this balance of CO2 and oxygen is because you can't just understand CO2 as a waste product. It's still considered this a medical school. Yeah, you don't need it. But people who study this know that is—it's absolutely essential to have that balance, you don't want too much. But you don't want too little. You want your body to be able to operate at peak efficiency without having to go through all those compensations, right? To keep you there.

Lisa: Exactly. So when we breathe in, we.. When I say, we don't hold our breath, and I'm holding my breath for a long time, as long as I can. And then that's horrible urgency that comes up and you start to—your diaphragm starts to make that sort of hiccup thing. And this is actually the chemoreceptors in the brain, which is the area that is what I understand, correct me if I'm wrong, that is measuring the CO2 levels more than anything in the blood, not the oxygen levels. And it's so, the CO2 going up, and then the body's going “Oop, time to breathe,” and it makes you do that, you know, hiccup thing in order to make you breathe. And when I'm doing my breathing exercises that I've learned from you, I let that reflex go for a while while I'm training my body and to be able to accept more carbon dioxide. And that will help me be a better athlete with a bit of a EO2 mix hopefully, and make me faster and so on. But it's the CO2, that's actually pushing the oxygen into the cells as well, isn't it? And that was another, a mind bender as well.

James: It's an exchange. So you can think about those red blood cells as this cruise ship, right? So and they're full of oxygen. And they cruise to areas where there are other passengers that want to get on this is CO2, and they exchange. The CO2 hops on as oxygen hops off. And this is just how it works. So that need to breathe, you're 100% right. A lot of people think, gonna exhale, hold my breath. “Oh, I don't have enough oxygen, I need to breathe.” No, that is dictated by rising carbon dioxide levels. And so many of us are so sensitised to CO2, that we can't hold our breath more than 10 seconds without going.

But they've done a study with athletes. And they found that to very comfortably hold your breath, over 25 seconds, 89% of those athletes will not have any breathing dysfunction. So this is a great practice to do. And this is why this is used in so many different breathing techniques for so long. The ancient Chinese were doing breath holds. Pranayama ancient Hindus were doing breath holds for thousands of years—is to exhale softly. And to hold your breath calmly. You don't want to be struggling and feeling your diaphragm moving. Just calmly, when you feel a little teaspoon of discomfort. You breathe and you calculate how long that is.

Don't look at this as a competition. I know that there's a lot of people out here. No, you can compete later. So what you want to do is to get your CO2 tolerance higher, because by having a higher amount of CO2, which is really a normal amount of CO2, your body can operate better. You will have more circulation. Oxygen will detach more easily. And when you're doing endurance sports, this is what you want. You don't want to use energy for things you don't have to use energy for. You want to be burning clean and tight. And that's what this allows you to do.

Lisa: This is about efficiency isn't and maybe you're saying that the average person is breathing 12 to 18 times a minute, on average. And ideally, we should be around the five and a half or six times a minute would be ideal. “So breathe light to breathe right” was one of the catchphrases that stuck in my head. And that's my trigger for all over breathing again. And so it's actually slowing down our breathing rate and not increasing the volume so much as diaphragmatic breathing. So using the deep, lower lobes of our lungs to actually get the breath end and doing it a lot slower. And why are we all you know, doing it 12 to 18 times a minute and overbreathing? Which is yeah. It is...

James: Sometimes a lot more than that. I mean, I've talked to clinicians who see people breathing 25, 30 times a minute just and they've been doing this for decades, and their bodies are just destroyed.

So it's, these things become a habit after a while and our body gets used to that cycle of compensation. And we start acknowledging this is normal. We started thinking having migraines is normal, having cold toes and cold fingers all the time is normal, being exhausted all the time is normal. None of this is normal. And especially if you look at modern populations of what's considered normal now, I mean, what 15% of Americans have diabetes, 25% have sleep apnea, 10% have autoimmune like, what is going on here? And that this is just accepted that, “Oh, just you know, I've my diabetes...”

Lisa: Aging.

James: ...my drugs. So anyway, I'm getting off track here. You when this becomes a habit, again, compensation different than health. And a wonderful practice to try is to breathe in at a rate of about five to six seconds, and breathe out at around that same rate. I put in the book 5.5 yet, but then people have been writing me, saying, 'I'm a half a second off'. Oh, my God. So now I'm saying anything in that range. And if that's too difficult for you, slow it down, go three seconds in three seconds out. It's perfect.

This is not a competition. This is about acclimating your body. So we can't breed this way all the time, that's going to be impossible. But whenever you become aware of your breath, that you're breathing too much, you can bring your breath back by breathing this way and recondition it. And the point of all these exercises is not to think about them. You want to do them often enough, that you're always breathing through your notes that you're always breathing lightly and slowly.

And that range of diaphragmatic movement, especially for athletes, I cannot tell you how essential this is, when you're breathing too much. Okay, here's what's happening, you're breathing up into your chest, which is extremely inefficient. There's more blood further down in your lungs, so can participate much more, much better in gas exchange. But you're also doing something else. You're taking air into your mouth, your throat, your bronchi, bronchioles, none of which participate in gas exchange yet do you bring it in? You go? I'm using maybe 50% of that breath.

If you slow down with the same volume, six laters a minute, to about six or seven breaths, right? Per minute, your efficiency goes up 35%. 35%. And if you're not gonna make a difference, you're running for five hour days. You're crazy. If you look at Kipchoge, check out how he's breathing, you know, an hour and a half, extremely light. He's completely in control, you can hardly see his chest. And he is in the zone.

Sanya Richards-Ross was the top female sprinter in the world for 10 years, check out how she's breathing through the nose in control, destroying everyone else and all of our competitors. So it takes us a while, which is why people don't, you're going to see a decrease in performance when you switch. Okay, guaranteed that it's gonna to go down. If you stick with it, it's gonna go up. I don't want to say that it's true for everyone. But I would say 95% and the breathing experts, the elite trainers I've worked with have told me 100% of the people they've converted, their performance goes up and the recovery is cut by half.

Lisa: Wow. And then I mean, who the hell doesn't want that as an athlete, you're fighting for 1%. So when we're talking, no such mess of possible changes that don't rely on your genetics and don't rely on you know, things that you can't control anyway. And like, for me, transitioning has been hard. I'll be honest, because I was completely congested all the time. And that's why I'd heard that nasal breathing because that’s the next thing we'll discuss that nasal breathing was very, very important for a number of reasons. I didn't really understand why. But I was like, well, I can't breathe through my nose is just blocked the whole time. And I don't have a show on hell of doing that. So well.

Well, I'll carry on doing my breathing. And then when I learn how to decongest my nose and sometimes it will take me two or three breaths. And the first time the first couple of weeks when I was doing it, my nose was running and I wasn't getting anywhere and I'm like, this is not working. But I pushed through that phase. And now I can run for like a team case at a fairly good pace, completely nasal breathing, if I do the warm up phase properly, if I go out the door and just try and do it straight out, the gate won't work, I need to do the walking, holding my breath, and get that cleared first, and then I can get into my training. And then I can hold it in the first 10 minutes, I'm still finding it a little bit like I want to breathe with my mouth, but that instinct is there. But I'm slowly training myself into that system.

And saying, I can actually, you know, I can actually run for a good hour just through my nose without any problems. And I've also not done the high-intensity. So I backed off the super high-intensity, because I know I'm automatically going to open my mouth when it gets to that. So while I'm in this transition phase, I'm not doing anything beyond that sort of aerobic capacity level. And I think I need this just to adapt. So these are huge types of people listening out there, if you are congested, and you think, well, this is all well and good guys, but there's no way in hell that I'm going to be able to breathe through my nose. Think again, there is, it's just a matter of being taught how to do it. And that's a pretty simple couple of exercises that were, you know, that's in the book. It can really, really help us if you persevere through it.

And then I expect to see improvements and my VO2 max and all the rest of it. Now, let's talk a little bit about the reason why it has to be nasal breathing. And so it's not just about breathing slowly. We've talked about breathing slowly, we've talked about diaphragmatic breathing. We've talked about CO2 and the role that we don't want our CO2 levels too low in the body. Let's talk now about the whole. Where was I going James? Help me out. I've just hit a..

James: You wanted to talk about breathing, you want to talk about fitness, you want to talk about nasal breathing.

Lisa: I hit a moment. So nasal. So we want to understand the physiology of the nose and why the nose is what we want to be breathing with rather than our mouth.

James: So I want to mention a few things. A few more things about running. This may seem overkill, but just a couple of points. So what I've heard from various instructors, Patrick McKeown is a world renowned breathing therapist, top got Brian Mackenzie the same thing. Never work out harder than you can breathe correctly. So if you're entering the zone, your mouth is open, slow it down and build your base and work up from there. Sometimes it took Dr John Douillard took him six months to fully acclimate. But once you get there, you are going to find a power in yourself that you did not know existed.

And this has been proven time and time again. When Carl Style was working with the Yale running team and the US Olympic running team. He said that these people suffered way more sicknesses, respiratory problems, asthma, COPD than anyone else. And he said, “They push through it because they're competitors. They're gonna push through it.” A complete mess. So there has to be a slight shift and thinking of like, you have to accept your performance is going to go down for a little bit.

Right now's a good time to do that. We're still in a pandemic. So you know, once things open up, you'll be kicking everyone's ass. And that's not a bad thing. But just know that this is a wave. This is a process. So the reason why you want to be doing this, we'll get to nasal breathing now is I will bring on my guest. He's been waiting over here patiently. Steve, for the people who aren't watching this, I'm holding up a cross section of a human skull. You can see the nose right here. When you breathe through the nose, you're forcing air through this labyrinth.

It's so similar to a seashell. It's called the nasal concha. So seashells have their shells this way to keep invaders out to keep pathogens out. Right? Our noses serve the exact same function. This is our first line of defence. So when we breathe through our nose, we're heating air which is important in cold climates where humidifying it, which is very important in dry climates. We're pressurizing it, we're conditioning it, we're removing particulate which is important, if you live in a city or basically anywhere else now. We're helping to fight more viruses. So there will be a smaller viral load breathing through the nose. And we condition this air so by the time it enters our lungs, it is properly conditioned to be more easily absorbed. When you're breathing through your mouth. You can consider the lungs as an external organ. Yeah, because they're just exposed to everything in your environment. So not only that, not only is this the most effective filter we have is it forces us to breathe more slowly. This is a self-regulating device. Yeah. How long did it take me to take that breath took a while? How long does this take? Yeah, nothing. So that's slower breath with that pressure allows us to gain 20% more oxygen breathing through our nose than equivalent breaths through our mouth. Again, if you think this is gonna make no difference to, you you're absolutely crazy. And this is simple science. You know, this isn't controversial stuff.

Lisa: No, this is simple science, but not well, knowing until your book came out and became a worldwide best selling book. Thank goodness because this stuff needs to be out there. And I'm called silly because I'm deep in the waves and in researching all the time. And by hacking and the latest longevity, and the goodness knows what I'm just always into the latest and greatest. And I'm constantly surprised at how you know that some fantastic information never sees the light of day, because of the systems that are in place, or traditions and laws and stuff. And it's like, wow, we have to get this information out there.

And this is one of those times when I'm thinking thank goodness, someone has put this into a book that's readable for people to understand the science without having to do such a deep dive themselves. And I think that that's really important. And that nasal, you know, nasal breathing. Also, it does another thing that I found really, really interesting was all about the nitric oxide. Can you explain what nitric oxide is and what it does in the body and why the nose is so important in that regard?

James: Nitric oxide is this amazing molecule that our bodies produce that plays a central role in vasodilation. Having more nitric oxide will decrease your chances of having a stroke, will decrease your chances of having a heart attack. It will increase circulation to your brain. I mean, I can go on and on here. It's no coincidence that the drugs Sildenafil also known as viagra, guess what it does, it releases nitric oxide in your body. That's how it cleans. Yeah, we get six times.

One study showed that we get six times more nitric oxide breathing through our nose than we do through our mouth. And if we hum we get 15 times more nitric oxide. So this has an incredible effect on the body and especially now there are 11 clinical trials right now where they're giving patients with COVID. Guess what? Nitric oxide. And apparently, according to Nobel Laureate, Louis Ignarro, oh, it's working wonderfully well in these. Studies are going to be out soon. I heard something. My brother in law's an ER doctor, my father in law's a pulmonologist. So we talk all about this stuff. And the vast majority of the people suffering the worst symptoms of COVID are people with chronic inflammation.

And as an opposite, very observational study. There are also mouth breathers. Yeah. And this was known 100 years ago, they were saying 75 to 80% of the people with tuberculosis are mouth breathers, chronic mouth breather. So there's been no official study on this just this is just observational stuff. Don't go write me about this, that your nasal breathing got COVID. It can happen.

Lisa: Can happen still, we're not saying that.

James: It's to me, but we know that can happen. But we also know something else. That breathing through the nose will help you defend your bodies so much more effectively, against viruses. And this is what Louis Ignarro again, he won a Nobel Prize. So listen to that guy, if you're not gonna listen...

Lisa: Yes and I've actually I've heard Dr Ignarro speak a number of times, and I'm hoping I can get him on my podcast to actually just to talk a whole session on nitric oxide and what he discovered, because he he won a prize for discovering this, this gas if you like in the body, because nobody really understood what it was or how it operated.

And it is being used for Viagra. And the reason it works for that is that it expands and dilates the blood vessels, but that's what's actually doing it and all parts of our body. And therefore when we're doing this nasal breathing, and we're getting more of that nitric oxide and I mean, a lot of the athletic supplements that you can get now in your corner supplement store are about, you know, drinking beetroot juice or whatever increases your nitric oxide. So this is another way to get at an info for you athletes out there. You want better performance, you know, a lot of my athletes are on beetroot juice and things like that. Just nasal breathing is another way of doing that. You know, so that's a really big piece of the puzzle, I think.

James: And those don't work. They certainly work but the key was so much of this just like with a key with oxygen. You don't like, go and get a bunch of oxygen for five minutes, then walk away so I'll fix them. You want to constantly be producing this stuff. So beet juice, you know what we'll work for a short amount of time. But to me, it seems like a much better idea to use something that we're naturally gifted with to use our nose. And to constantly be having a body that can constantly produce a healthy healthy level of nitric oxide. I drink beet juice.

I'm a big fan of that, the nitrates and other vegetables can help release more nitric oxide. Great stuff, right? But nasal how often can you be drinking beet juice, you don't want to be drinking that 10 times sugar in it.

Lisa: No. There's a lot of sugar in it.

James: There’s a lot of sugar in it and you know, occasionally is great, but there's other ways of doing this. And you know, I think our bodies are the most powerful pharmacists on the planet and that's been shown so why not try to focus on your body and health a little bit? Well last thing I want to mention that I just find, is so frustrating here in the US is all this talk of COVID all this talk of you know wear a mask, which I'm a believer in that stay at home. I'm a believer in that. Zero talk about not eating four double cheeseburgers a day.

Lisa: Hey, mean.

James: Ola, like getting your health and breathing through your nose. like where's that conversation? Getting vitamin D, getting vitamin C. And so anyway, we've seen what the government's you guys have a much more progressive government, let me tell you, we're so jealous of it. But now we have the whole...

Lisa: We’ll be a medical society, though there's nothing. It's not that late. But yeah, and I've had a number of episodes, I've just done a five part series on vitamin C, and intravenous vitamin C, and cancer, and sepsis. And, you know, the whole gamut in the problems there. In this, every single doctor has said to me too, when it comes to COVID, why aren't we building up our immune system so that we don't get people in our ICU on ventilators? You know, so that we don't get to that point, or we have less people and, you know, that just seems like a no brainer to me, but we're still promoting eating crap and drinking crap. And, you know, and not taking into account. It's, yes, I mean, the vaccines and all that, but how about we just take a little bit of self-responsibility we might not have as bad if we do get it.

You know, like I've got a mum. I've just written a book called Relentless that my listeners know about and it was about rehabilitating my mum back from an aneurysm four and a half years ago, where she hit massive aneurysm. Hardly any higher function, I was told, like, should never do anything. Again, I spent four and a half years rehabilitating her and she's completely normal. Again, she's driving the car, she's walking, jogging, everything's fine. And this is why I've ended up doing what I do, because I'm very passionate, because none. And I mean, none of this was offered in the standard medical system that we were in. They were great at the surgeries, they were great in the crisis.

But when it came to rehabilitation, there was just nothing there, and so I discovered all of these things. And one of the passions I have is just staying one step ahead of here and giving her the next thing now she's 79 years old, I want to keep her healthy. So when COVID threatened us, you know, I've, you know, got over there in the corner, my hyperbaric oxygen chamber, my ozone over the air, and, you know, you name it. I've got it so that if it does come, we prepared as prepared as we can be. And that is a good approach, I think prevention, rather than waiting for the disaster, and then trying to pick up the pieces at the end of the day. You know?

James: Yeah, and I just want to be clear, and I know that you're saying the same thing here. There's, doctors in my family that practice Western medicine who've helped people, when I get a car accident, last thing I want is acupuncture. I want to go to the ER and have somebody say, “Sir, I break a bone. I'm not doing pranayama breath work, I'm going to go and get a cast.” But about rehabilitation. This is 100% true, because it costs a lot of money.

There's no way a system can support full rehabilitation. And one thing that I've heard from almost every expert in the field, whether it's a professor at a university, or an MD, or a nutritionist, or whatever is they believe, this isn't my view. This is their view. I want to be objective here but they believe that there's a reason people aren't talking about breathing again. It's, there's no money in it. There's a money. Oh, why the US government isn't saying “Don't go to McDonald's today.” That's going to shut the economy down. So the good news about this is people who are interested want to take control of their health. There are now other means of getting information from people who have studied this stuff, people who are into scientific references, who are looking at science in a real objective way.

And so I view this thing, hopefully, this is going to be a lesson we can all learn then that we can acknowledge how incredible the human body is, how we become susceptible to illness, and how to better defend ourselves in the future.

Lisa: I'm just so on board with all of that. And I think it's our right and this is a problem we do. You know, we love Western medicine, they do some brilliant things. I love naturopathic medicine, I love alternative, complementary, whatever you integrate, or whatever you want to call it.

We've all got deficits, and we've all got blind spots, and every single piece of this. And it's about bringing the whole lot together, and not letting money rule the world. I think is, if we can ever get to that point, that would be fantastic because it is at the moment. And there's a lot of things that are being hindered, like things, simple things like breath work, like stress reduction, like intravenous vitamin C's, like things that don't, nobody can make money at, or hyperbaric oxygen is not going to make millions for anybody. So it's not getting out there, that information is not getting out there. And it needs to be out there.

We got I reckon we could talk for days, the job's because we were obviously on the same track. But I wanted to touch on a couple of areas. One was the whole skeletal muscle record of our ancestors and our facial, you know, our whole facial development and why that's part of the problem and the food problem, the mushy food that we eat today. And then remind me to talk briefly about the immune system and all this inveigled the vagus nerve and stuff. So let's start with though, with the skeletal record, and the difference between our ancestors and how we are today.

James: So early on in my research, I started hearing these stories about how humans used to have perfectly straight teeth and I don't know if you're like me. I had extractions, braces, headgear, you name it, every single person I knew had the same thing. It was never if it was just went this is what how it was done. At wisdom teeth removed. If you think about how weird that is, you're like, why are we removing teeth? From our mouths? Why are teeth so crooked? Where if you look at any other animal in the wild, they all have perfectly straight teeth. And what I learned was that all of our ancestors, before industrialisation, before farming, any hunter-gatherer all had perfectly straight teeth. So I went to a museum and looked at hundreds of skulls, and they all stared back at me, these perfectly straight teeth. Completely freaked me out.

They had these very broad jaws, wide nasal apertures forward, growing powerful faces. So if you have a face that grows this way, and you have a mouth that's wide enough for your teeth, you have a wider airway. Having a smaller mouth, you have less room to breathe. And this is one of the main reasons so many of us struggle to breathe, we have upper airway resistance syndrome, sleep apnea, snoring, and so many other respiratory issues is because there's less room in there. And what happened is this came on, in a blink of an eye with industrialised food in a single generation.

People went from having perfectly straight teeth, wider nasal apertures, to having crooked teeth and smaller mouths and a different facial profile. And this has been documented time and time again. Yet I had learned in school, which for me, it was zillion years ago that this was evolution-meant progress we're getting we're always getting younger, you're getting taller, we're getting better, look around the day and ask yourself if that's true, it's complete garbage. And then I went back and looked at the real definition of what evolution means. All it means is change and you can change for the better, or for the worse. And humans, as far as our breathing concern is concerned, are changing very much for the worse.

Lisa: Wow. And so we're, I mean, I'm saying I grew up have had so many extractions and teeth completely crooked and a tiny little mouth and all of those sort of problems that you're describing. So what was it that their ancestors did differently? So it was just the food being not we not chewing as much was that basically? Yes, like that's that was a real chain game changer for us when the industrialisation happened and we got mushy food.

James: There were many inputs, chewing is the main one. So when you live in an extremely polluted environment, sometimes your nose can get plugged, right? You start breathing through your mouth, that can create respiratory problems, but if you breathe through your mouth long enough, your face grows that way actually changes the skeletal picture of your face. So that's another input improper oral posture is what that is called, but it's for when you're younger chewing is so essential and it starts with breastfeeding.

There were no Gerbers food. I don't know if you have that out there, but there were no, like, soft foods. Just a few 100 years ago. So if you think about it, so now we're eating the soft processed foods right out of the gates. We're going, we're being fed on a bottle, soft processes. All of our mouths are too small and too crooked. So this chewing stress starts at birth. They've done various studies looking at kids who were bottle fed versus those who are breastfed.

When you're breastfed, your face pulls out your mouth, gets wider because it takes a lot of stress to do. Two hours a day, like every day, every two hours, you're doing it. And literally, and I've talked to parents who had twins, I just talked to a lady yesterday who bottle fed one did love not want to be breast fed breast fed the other. They look totally different. One has crooked teeth, one has autoimmune problems. One has swollen tonsils, the other doesn’t. So that is anecdotal.

But there's been studies in the 1930s they did tons of studies into this. So I'm a dude, I'm not going to sit here and tell everyone they breastfed people for that is not my point yet. But some people just can't. But I think it's important to acknowledge that the physics of how this works. And after that, if you have bottle fed a kid that's fine. But they need to start eating hard foods baby led weaning, this is what needs to happen to develop that proper jaw to develop that proper airway.

And even if you don't do that, if you then go to soft foods, and your kid is two to three years old, and it's snoring or sleep apnea, which is so common now it's so tragic, because that leads to neurological disorders, ADHD, again. This isn't crazy New Agey. This was at Stanford, there's 50 years of research on this from the top institution here. So there are direct links between those things, but luckily we have technologies now that can help restore to the mouth to the way it was supposed to have been before industrialisation. They actually widened the mouth of these small little kids, and open their airways, and it drastically improves their health.

Lisa: Today so it's palatal expanders that you you tried out and actually isn't even as an adult was you developed I remember it was at eight coins worth of new bone in your in your face and in a year or something crazy so we can still so if you've missed about if you've not received your kids or your you didn't get that yourself or whatever, it's not all over there is things that you can start doing even starting just to chew now like that to eat some carrots and whatever you know, whatever hard foods you can find to actually use those that powerful joy in order to make it stronger.

It's just like every other muscle in the body isn't it? And when we're mouth breathing to our remember you saying or the muscles here get lax and flattered and just like any other muscle that we're not training, if we're if we're going to mouth open all night and we're you know, then we're causing those muscles to be lax and over time that that leads into sleep apnea and things as well can do. So yeah, so this is something that we can practically get a hold on now even if it's a bit late for you and I think.

James: Yeah, I talked to my mum I was bottle fed after like six months my mum was like six months is a long time when I was growing up bottle fed soft foods industrialized crap my off intel I was you know 25 and it discovered these things called vegetables. But you know, so so this isn't pointing the finger at anyone we were sold this story by our governments that said you shouldn't eat mostly refined grains, eat your Cheerios, eat your bread, or crema wheat eat your oatmeal like that this is eat your sugar, that's good. Eat your chocolate milk, you know, so we have knowledge now we know the folly of our ways.

But the one thing that was inspiring to me this is easier to do, when you've got a developing kid quickly growing it, you can set the foundation and their face will grow around like their faces grow different. It's just, it's beautiful to see how the body forms to its inputs. So I, you know, youth was several decades ago for me, for far too long. I was a child of the 70s and 80s. Right? Yeah, we thought I thought once you're in middle age, you're completely screwed. What can you do, but that is just a convenient excuse for people to say, “Oh, it's genetics. Oh, I inherited this.”

Like genes turn on but they can also be turned off and so I wanted to see what how I could improve my airway health in a year and so I took a CAT scan, and I did proper oral posture, you're 100% right when, when you're just eating soft, mushy food in your mouth is open. All of those tissues can grow really flabby just like anywhere else on your body. But if you exercise them if you exercise the jaw, the strongest muscle in the body, you know, for its size, the tongue, extremely powerful muscle, you exercise these things, they get tone like anything else. And this can help open your airways. So this is just an anecdote, this was my experience, it'll probably be different for other people. But I did a number of these things.

And a year later to the week, I took another CAT scan, and the results were analysed by the Mayo Clinic, which is one of the top hospitals here. And they found that I increased my airway size about 15 to 20%. In some areas, and I can't tell you just as a personal story, it has absolutely transformed my life because I can breathe so much more easily through my nose. At night. I am silent. I didn't snore before but I was knowing that my wife would always tell me, totally silent now. And of course I am because I have a larger airway, things are more toned air can enter more easily.

Lisa: Is it easy to find palace expanders are these like any a couple of dentists in the world doing this sort of stuff?

James: Not everyone needs palatal expansion. I've gotten so many hundreds of emails of people, you know how we are, it's like, what's the latest thing, oh, there's a new pill, there's a new device. Oh, I get it, that's gonna solve all my problems. So they can really help people who need it just like surgical interventions. For people who have severe problems in their nose are a huge help. They're transformative. What I found is a lot of people don't need that. And what I firmly believe is start slow, start low, see what your body can naturally do. If after six months, you're like, ‘I'm still not this isn't working,’ go see someone you know, and take it from there.

But palatal expansion absolutely works for people who really need it, but you would be amazed by just doing something called oral-pharyngeal exercises. There was a study out in chest, which is one of the top medical journals, you know, they found this significantly cut down on snoring, not lightly, significantly. And all it is, is exercising the tongue, roof of the mouth, proper oral posture, just working out this area. Toning it, of course, that's gonna help you if this is flabby and hasn't been to..

Lisa: The gym for your mouth.

James: That's what it is. And I view that world, there's a whole separate school called myofunctional therapy that is helping people do this, which is so beneficial. They focus mostly on kids, but they also work with adults. And this is what they do. They are the instructors, the gym instructors, for your mouth and for your airwaves. And I strongly recommend people looking that up, there's a bunch of instructionals for free on YouTube, you can go that route as well.

Lisa: Oh, brilliant, we'll link to some of those on your website. And, you know, I get people those resources. It's just, it's just amazing and fascinating stuff. And who would have thought this conversation would go so deep and wide, I wanted to just finish up then with talking about the immune system and stress reduction and vagus nerves and all of us area too, because, you know, me included in this and most people are dealing with, you know, massive levels of stress, and breathing can I've, since I've read your book, and I was really, you know, quite aware of how to bring my stress levels down and movements and the importance of you know, yoga and all those sorts of things.

I've had that piece of the puzzle sort of dialed in, if you like, but the breathing exercises and actually calming the nervous system down within minutes. Now I can fall asleep in seconds. And you know, what seconds is a bit exaggerated but minutes, and I can I can take myself from being in this emotionally, my god and i tend to be like that because I'm like, you know, busy, busy, busy. And then go, “Hey, I'm spinning out of control. I've lost control of my breath. And I hear myself and I pick myself up on it now.”

And I go and do two minutes of breathing exercises. That's you know if that's all I can afford to do, and I can switch into parasympathetic now, that's been gold. Can you just explain why the heck does doing this slow light breathing diaphragmatically stimulate the parasympathetic nervous system and the vagus nerve from what's actually going on there?

James: Sure. So what people can do now is take a hand and you can place it on your heart. And you can breathe into rate of about three seconds and try to breathe out to about six to eight seconds, just whatever's comfortable. Now, breathe in again. 123 and exhale. And as you're exhaling out very softly, you're going to feel your heart rate, get lower and lower. And lower. So when you are exhaling, you're stimulating that parasympathetic side of your nervous system, our breath can actually hack our nervous system function.

And by exhaling more, and taking these long and fluid breaths, you can trigger all of those wonderful things that happen when you're parasympathetic. You reduce inflammation very quickly. You send signals to your brain to calm down. You actually change how your brain is operating the connectivity before the between the prefrontal cortex and the emotional centers of the brain changes when you slow your breathing.

So throughout the day, if you want to remain balanced, you take those soft and easy light, low breaths, to account of whatever's comfortable, three, four, even up to six, and six out. But if at some times you feel “My stress levels are starting to increase. I'm feeling my mind slip. I'm making rash decisions.” Start extending the exhale. An exercise I like to do is inhale to about four, exhale to six, you don't have to do it that long. Inhale, two, three, exhale to five, whatever's comfortable, as long as that exhale is longer, you're gonna feel your body slowing down.

And if you don't believe me, all you need to do is get your heart rate variability, monitor your pulse oximeter and take a look at what happens after 30 seconds of slow, focused breathing. And you will see this transformation occur in your body, if that can happen in a couple minutes, what's going to happen to you after a couple of hours of taking control of your breathing, or a couple of days, or a couple of months.

I'll tell you what's going to happen. I talked to dozens and dozens of people who have fundamentally transformed themselves through nothing more than breathing. I want to mention again, I'm not promising this is going to work for everyone for everything. But it needs to be considered as a foundation to health.

Lisa: And you need to stick at it for a little bit. And you know, I do my HIV monitoring every morning before I get out of bed and do my breath holding exercises and look at my boat score from Patrick McKeown. And you know, all that sort of stuff. Before I even put my feet on the floor, and I yeah, I can control my heart rate to a degree just through my birth weight. So I know this works. And I know that when I do a longer exhale from that, and compared to the inhale, immediately, I just feel a bit more calmer, and a bit more in control.

And it's reminding myself and this is the trick because we, when we're in the middle of work, and we've got meetings and phones are going and emails are coming at us, and it's like the “Lions are chasing me.” And it's been trying to remember to breathe in. Bring yourself down and calm yourself down. And just take that couple of minutes many times a day, you know, depending on how stressful Your life is. And in doing that on a regular basis, over time will have massive implications. Because we're talking here, your digestion. You digest food better if you're in a parasympathetic state versus a sympathetic, your immune system.

Again, coming back to COVID in that conversation, you're going to be improved, you know, your hormone balance. Yeah, just to fix everything, the way your, the brain waves, all of these things are going to be affected by your stress levels. And what is the easiest quickest way to reduce your stress? You breathe. So I think you know, that's a that's a really, really top tip. This just before we wind up and I've taken enough of your time, James but I you did in the, towards the end of the book, you went into some extreme super breathing practices, which because I was like, wow, okay, because I you know, read all about Wim Hof and looked at his breathing techniques.

And I was like, wow, how how does that work, then? Because I'm over breathing when I'm doing that. How does that work? What is there a specific time when that type of breathing or the extreme breathing one pops just one of them? But you know, is there a reason to be doing that type of extreme breathing stuff? Or can it help? Or is it just for crazy like good, crazy, but crazy.

James: Seems so counterintuitive, after learning about all these benefits of breathing less and breathing lightly, to then practice something where you're breathing like this. Yeah, and I was like, What is going on here? These are two completely opposite things. But think about those breathing practices like going to the gym. You're not going to go to the gym for 24 hours a day you're going to destroy your body, but going to the gym for half an hour and working out going to the gym for an hour and working out says huge benefits to so these breathing practices are all about working out the body and working out the respiratory system and working out your stress.

Okay? So they purposely stress you out. A lot of people think “I don't want to stress that, why do I want to do something that stresses you out?” The point is, they teach you to control your stress, you consciously bring stress on, and then you consciously turn it off. And this hormetic stress, these short bursts of stress are so beneficial to our bodies, because we are not meant to be sitting on soft sofas and soft beds, eating soft foods, watching soft TV programming all day, we're meant to work out sometimes. And that's what these are so effective for doing. Some people find them jarring if they haven't done any breath work.

So I suggest people start with that foundation of nasal breathing, breathing, awareness, breathing slowly and all that. But for some people for whom nothing else's work, no other drug has worked. I'm talking about people with autoimmune diseases, rheumatoid arthritis, even amass of psoriasis. I mean, the list goes on and on. I've seen this time and time again. And the science is very clear that this hormetic stress, doing this in a controlled way, allows you to decrease inflammation for the other 23 and a half hours of the day, which is exactly what the parasympathetic state does.

So I love what you call Wim Hof Method, he's the first person to say I talked to Wim semi often I love what he's doing. He's such a cheerleader, he changed people's lives. Love the guy. He knows this isn't his method. This is 1000 year old stuff, you can call it Sudarshan Kriya, you can call it pranayama. Whatever all these methods are so similar, because they do the same thing. They have you breathe very intensely. And then they have you hold your breath or not breathe at all. And then they have to breathe very intensely.

So this is the interval training, you see what's going on here. So this is HIT training for the respiratory system. I'm a huge fan of it. I use it as much as I can. I've seen big benefits to it. And it so happens to be right down the stream from me at University of California, San Francisco, Dr. Alyssa Apple, who is the expert in telomeres, had a famous book out a couple years ago. She's now studying this stuff, breathing and arthritis. And her study is coming out next month. I'm talking to her next, next week. So this stuff in, in my view, especially with athletes, the people getting the calls now are people that are focusing on breathing Brian Mackenzie elite in stride, length is Brian. He's doing this is all he's doing now.

Lisa: Yeah, these guys are just on the next level. And when I first read the book, and I you know, read Patrick's too. And I was like, hang on, I don't get this because I was into the Wim Hof stuff. And I was like, yeah, I'm doing that sort of stuff. And but, you've just really clarified that for me, actually put that into sort of mistake, that part of it. That it is, like the intense interval training. So you don't want to be doing this 24 seven, you know, you want to do this with a specific purpose for a specific short period of time to create a stress just like you do when you go in train your backside off, and then you come back and you recover from that and it just that push and pull.

And on you're so right, like, we and this is an issue in our, in our world now we are so comfortable. We are so warm all the time and cozy, you know, in our clothes, clothes and their cozy houses and our cozy cars and now we never get outside and we need as human beings to be pushed and pulled and out in up and down and have challenge, you know, challenge both mentally and physically. I think to keep ourselves strong and we don't, that's when we you know, fade away and have problems and get sick and all those sorts of things. So I'm a big, you know, mean, pushing the limits is the name of my podcast for crying out loud. You know.

James: I actually talked to Patrick quite often, we correspond all the time. He and Anders Olsson told me at the beginning they're like, Oh, this heavy braid. This is bad. This is bad. Yeah, Patrick's come around now. Worst wins book. He's like, Wow, this is great stuff. So he's starting to incorporate this stuff. Because again, it's Westerners, it's we always think, it's needs to be one or the other. You're the slow breather, you're the fast breather, your paleo or your vegan, your kid. These things all have benefits to me. They're more tools in the toolbox to use at different times. And we're showing this these short periods of intense breathing can really be this pressure release valve for stress.

And I'd be surprised if someone does the Wim Hof Method or Tummo. I'd be surprised if anyone is feeling more stressed after that. I mean to me, I find this is a very powerful tool. I use it before sleep sometimes, man the second my head hits the pillow. I'm gone in about eight hours. And that's what you want. That's brilliant. And it's good to Yeah, that Patrick's saying that, that Toby and Patrick's coming on the show in a few weeks time, so I'll ask him about it. Because I, you know, like I've been fooled do I, you know, because I've been doing the Wim Hof stuff previously, and now I've like, all backed off of it.

But now I might have another crack at it again, and go a little bit deeper and just see if I can, you know, get to the next level. Because I mean, there's slow breathing for most of the time and certainly controlled in the in the training, and then there in the running and so on, is what you want to be doing most of the time, but we want these little stressors, these are medic stressors in order to improve and…

James: Guess how one breathes the rest of the time. He rolls through his nose. Yeah, really slowly. And he hums a lot. Increase nitric oxide. So this is everyone sees him as the maniac screaming at you to breathe, and they don't see him the other 23 and a half hours a day where he's very chill, you know? So this is again, it's not one or the other. It's able to look at the benefits of all these things, just like the benefits of all these different foods that pick out the ones that work for you and to use them.

Lisa: Excellent. I think that's a beautiful place to wrap it up. James, thank you so much for writing this incredible book, and for sharing your knowledge and spending so many years because I know this was a lot of years of research that went into this. Please everybody go out there and buy this book. Get the word out there, share it with your friends and family the links will be in the show notes. But James, where can people find you and in your book and where they best to get it?

James: My website is a good place to start. I've listed all of the scientific references because I know this stuff sounds completely wacko. You can see videos, you can see expert Q and A's with a Harvard professors. There's exercises from Johns Hopkins. All of this is free. And it's at mrjamesnestor.com. There's links to the book too, because the how of breathing is the easy part. It's to me I found the more interesting story was the, what does it do? Where does this come from? You know? In what ways can it help benefit us and that's what I focused on. I'm also on Instagram trying to get better at this social media crap. And I'm posting things related to only breathing there.

Lisa: Yeah, Instagram, you probably need to do a bit of Wim Hof before you jump on it because all the social media has drives me nuts too. But we have to do it. We live in this world. We do James, thank you so much. It's been an absolute honour to meet you. And I'm really, really grateful to you.

James: You have to promise in six months after continuing to nasal breathe and work out. I want to hear a full report on where your endurance levels are and your performance levels.

Lisa: You got it, maybe I'll be competing again with Lenovo. That's great. Thanks a lot for having me.

That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends and head over and visit Lisa and her team at lisatamati.com.

Download this Episode

Nourish Your Body with Detoxification and Metabolic Fitness with Dr Bryan Walsh 0

Jan 21, 2021

No one is exempted from exposure to environmental pollutants. While this may sound worrying, there are steps, backed with scientific and empirical evidence, to rid our bodies of these harmful pollutants. However, there is still a lot of misinformation about detoxification that we need to uncover.

In this episode, Dr Bryan Walsh discusses the common perception about detoxification and explains the actual science behind it. He talks about the different phases of detoxification and its complexity. Dr Walsh also tackles the importance of excretion as a widely ignored aspect of detoxification in diets and weight loss programs. Detoxification may seem challenging to start, but it begins with getting to know your body and blood chemistry.

If you want to know more about the science behind detoxification, then this episode is for you!

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Here are three reasons why you should listen to the full episode:

Learn about the phases of detoxification.
What is the assessment criteria for detoxification?
What is the importance of context in detoxification?

Resources

Try out a Metabolic Detoxification Questionnaire here. Alternatively, you can look for other questionnaires by searching for ‘metabolic detoxification questionnaire’.
Detoxify or Die by Sherry A. Rogers
Fasting Mimicking Diet Program by Dr Valter Longo
Metabolic Fitness
Curious to start your detoxification? Try out the Walsh Detox Program!

Episode Highlights

[04:47] How Dr Walsh Started Studying Detoxification

Dr Walsh was interested in health and fitness from a young age. He eventually ventured into massage therapy and became a fitness professional.
He took a postgraduate degree to become a naturopathic physician.
After his education, he felt that he had to study more to serve his patients better.
His goal is to connect conventional Western medicine and alternative medicine.

[09:56] Views on ‘Toxin’ and Detoxification

Dr Walsh cites some ridiculous notions surrounding detoxification. In the 80s, it used to be rehabilitation for addiction to alcohol and drugs until everybody started hopping on the ‘detox bandwagon’.
Xenobiotic or commonly known as ‘toxins’ is something foreign to the body that can cause damage in excess.
When water leaves the body in any form, water-soluble toxins leave as well. Meanwhile, the body still needs to turn fat-soluble toxins into water-soluble toxins to get rid of it.
Our bodies are naturally built to detoxify pollutants through biotransformation.
Listen to the full episode for an in-depth discussion on toxins!

[16:11] Categories of Pollutants

First is heavy metals. This category includes aluminium, arsenic and mercury, among others.
Second is persistent organic pollutants, which include phenol, dioxins and pesticides.
The last category is volatile organic chemicals (VOCs) that are usually inhaled.
In essence, pollutants are everywhere.

[17:41] Everyone Is Exposed

While everyone is exposed to pollutants, the levels may vary due to location and lifestyle.
For instance, Dr Walsh believes that athletes may be less toxic due to sweating during exercise.
Listen to the full episode to know the body’s pathways for getting rid of environmental pollutants.

[23:04] The Difficulty in Assessment Criteria

There are a lot of variables and testing methods to consider in assessing toxin exposure.
The fat biopsy is regarded as the gold standard test. However, because different body areas store different amounts of fat, there’s no consistency in the body.
Taking these tests can guide you to make different lifestyle changes. However, keep in mind that they cannot determine your body’s toxicity level quantitatively by an absolute number.
Listen to the full episode to learn more about the complexity of detox questionnaires.

[30:00] Nature of Pollutants

Toxin gets stored in a cell or area with low concentration. This is called the concentration gradient.
If there’s more toxin in the blood and less in the cell, it will get stored in the cell.
When fasting, you go into a catabolic state. Studies have shown that xenobiotics in the blood increase in this state.
All detoxes are cellular detox.

[33:43] The Phases of Detoxification

Phase 0 starts with the fat-soluble toxin entering the cell.
Phase 1 is the reaction with the addition of a hydroxyl group.
Phase 2 concerns conjugation reaction of adding methylation, sulphation and the like.
Finally, phase 3 is when excretion happens.
Tune in to the full episode for Dr Walsh’s analogies and a detailed explanation of each phase!

[42:06] The Three Pillars of Detoxification

The keys of detoxification are mobilisation, biotransformation and excretion.
Mobilisation is getting pollutants out of storage.
Biotransformation encompasses phases 1 to 3.
Excretion should take the toxin out of your body.

[47:34] Effects of Dieting

Dr Walsh recommends doing a weight loss program in conjunction with a detoxification program.
During periods of weight loss or catabolism, xenobiotic levels increase.
The problem with rapid weight loss and yo-yo dieting is the redistribution of toxins in the body without excretion.

[53:22] Nutrients and Detoxification

Being nutrient sufficient is enough to support phase 1.
Phase 2 is driven by amino acids.
Phase 3 can be blocked by three inhibitors: milk thistle, curcumin and green tea. However, note that the effects of these three inhibitors are based on its dosage and the context.
One protocol will not work for everyone; you have to look at the totality. Listen to the full episode for more details about nutrients and botanicals!

[1:05:00] The Nature of Symptoms

For Dr Walsh, thyroid dysfunction may be secondary to another issue.
Once symptoms show, you should consider if it is a protective reaction.

[1:11:32] Advice for Detoxification

Dr Walsh shares details about his detox course, including a practitioner-based programme and The Walsh Detox for the general public.
Your blood chemistry is essential in determining your detoxification programme.

7 Powerful Quotes from This Episode

‘I’ll be the first to tell you that science will never prove some of the things in life that are the most important things — relationships and love and how we try to study how the brain works — and I don’t think we have any idea’.

‘This is part of my problem with the industry is we can’t even decide on what a toxin is. . . So what I would suggest, the one that people are most talking about, that’s why I think environmental pollutant or environmental toxins make more sense because usually what people are talking about are things that are outside of us that get inside of us and cause damage of some kind’.

‘They will test their blood, their urine and their sweat for a specific xenobiotic or environmental pollutant. And they will find in many cases, it’s not in the blood, it’s not in the urine, but it is in the sweat’.

‘Everybody’s toxic. Everybody needs to detoxify. . . It’s not necessarily exposure; it’s we all have some degree of storage. The question is, when somebody is not feeling optimal, is it because of that or not? And so you can’t run around screaming everybody’s toxic because I don’t know that they are’.

‘And so it’s [toxins are] concentration gradient-based, which also means so that’s how it gets stored. If there’s more in the blood and less in the cell, then it will tend to go into the cell. And that’s when it gets stored’.

‘There’s some ridiculous stories out there that will say, ‘The body won’t release toxins if it’s not healthy enough, and it doesn’t think it can deal with them’. That’s not true’.

‘I’m against protocols; because one protocol will be brilliant for one and harmful for another same protocol’.

About Dr Walsh

Dr Bryan Walsh has been studying human physiology and nutrition for over 25 years and has been educating others in health for 20 of those years. When he isn’t teaching, he spends his time poring over the latest research and synthesising his findings into practical information for health practitioners to use with their clients. He has given lectures to members of the health care industry around the world and consistently receives positive feedback in his seminars and courses.

His online educational platform, Metabolic Fitness, helps health professionals to stop guessing and start knowing what to do with their patients.

Dr Walsh is best known for challenging traditional dogma in health and nutrition concepts, such as questioning current models of adrenal fatigue, glucose regulation, detoxification, mitochondrial dysfunction and more.

As such, he has been sought out to consult with multiple companies, academic institutions and wellness organisations. Dr Walsh is also a board-certified Naturopathic Doctor and has been seeing patients throughout the U.S. for over a decade.

Outside of his professional endeavors, you can find him spending time and having incredible amounts of fun with his wife, Dr Julie Walsh, and five children.

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Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn more about the science behind detoxification.

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For more episode updates, visit my website. You may also tune in on Apple Podcasts.

To pushing the limits,

Lisa

Full Transcript Of The Podcast!

Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com.

Lisa Tamati: Hi, everyone, and welcome back to Pushing the Limits. And today I have just a super superstar for you, Dr. Brian Walsh, who's sitting in Maryland in the USA. Dr. Walsh is someone that I've followed for a long time and learned from. He is one of the great teachers in biochemistry and physiology. And today we are discussing detoxing very relevant to this time of the year. And this is all really next level information. Because it's all about detoxing, like what are the actual physiological steps of a detox process? And what is the latest and current research. This is not something you read in a two page magazine article detox type of thing. But this is the real deal with someone who really, really knows his stuff.

Now, Dr. Brian Walsh has been studying human physiology and nutrition for many, many years. And he spends his time sort of poring over the latest research and synthesizing all of that information for the layperson to be able to understand. And he also lectures at Western States University in biochemistry. And as a healthcare professional, he's a doctor of naturopathic medicine. And he has an online educational platform called metabolicfitnesspro.com, where he helps other health professionals like myself, and many, many others, as well as lay people with his programmes and courses.

And we're going to be discussing today, as I said, detoxing, how to do it properly, when not to do it, what to be aware of if you are doing it. And he's you know—Dr. Walsh is someone who's really known for challenging traditional dogma in health. And he actually goes and does all the research, does deep deep dives into all of the clinical studies into PubMed, and then brings us the latest and information. So he's really someone that you want to have on your radar, someone that you want to know, if you want the latest and greatest in information.

I hope you're enjoying your Christmas time, by the time this episode comes out, Christmas will have been passed. And we're into the new year. And hopefully the world is on a new trajectory and that 2021 is going to be a hell of a lot better. And what better way to start the year than with a discussion around detoxing and getting your body in good shape for the year ahead. So without further ado, I'll be heading over to Dr. Brian Walsh.

And just a reminder too. If you want help with any health issues, if you are dealing with anything, please reach out to us lisa@lisatamati.com. You can reach me on email. If you're wanting information about our online run training programmes at Running Hot Coaching, want personalized run training, please do reach out to us as well. We just launched a new package that will be coming out in the next few weeks. So keep an eye out for that where we're going to be offering video analysis, as well as fully customized programmes and a session with me—all included in there in a package price. It's really really a no brainer. So if you want to find out about that, please reach out to us at lisa@lisatamati.com.

Of course our epigenetics programme is still open, if anyone wants to know and understand the genes—understanding everything to do with your genes, eliminating the trial and error for your body, understanding what foods to eat exactly, which areas you're predisposed to have problems with, how your brain functions, what your dominant hormones are all of this sort of great information. Please also reach out to us and we can put you in the right direction. We've done a few webinars already on our epigenetics programme. And in the coming weeks, we're also going to be having Dr. Ken McDonald on from PH-316, who's going to be going a little bit more deeper into this. So I hope you enjoy the session though for now with Dr. Brian Walsh. And we'll head over to him right now.

Lisa Tamati: Well, hi everyone and welcome back to the Pushing The Limits. This week, I am super excited. I'm jumping out of my skin. I have a man who I really, really admire. I love his work. He's got an incredible brain. Just absolutely mind-mind conversation we were going to have today. I have Dr. Bryan Walsh with me. Welcome to the show, Dr. Walsh.

Dr. Bryan Walsh: Thank you so much for being here.

Lisa: It's a really, really an honour to have you on. Dr. Walsh, you’re still in Maryland, in the States? Can you give us a bit of a background just on who you are and sort of a quick synopsis and your background as a physician, etc.?

Dr. Bryan: Well, yes, I guess I should say it all started out, I was very much into health and fitness, even at a young age, quite honestly. I became a fitness professional—that’s how I started. And then I did a lot of orthopaedic work, so that led me to massage therapy. So I did massage and I was a fitness professional. And the problem is my clients would ask me health advice. And here in the States—I'm a law-abiding citizen—I could have talked to them about nutrition and supplements, but I wasn't allowed to with those things that I did.

So then I looked—and there's something in the States, it's a naturopathic physician, naturopathic doctor. I know you guys have naturopathic there. They're a little bit different. It's a four year postgraduate degree. So you go to four years of university, and the traditional four years. And then you have your doctorate. That sounded really good to me because I was already into alternative health. I was devouring books, on health, on herbs, on homeopathy, everything in the health. And that was the umbrella for all these things that I was interested. And I thought, wow, that's great, perfect.

So I went through four years of that. Spent way too much money. But it's also where I met my wife. So that is money rally well spent. Yes. Although we both went to school there. So we doubled our debt, essentially, by marrying each other. But what we quickly realized is that it didn't really prepare us to do what we wanted to do. And it didn't take long. I was sitting in front of patients, and I honestly—I didn't think I know what I was doing. I didn't feel qualified. I spent all that money over the four years of school with great classes, but it sounded like all these great topics but...

And so that started me—and this is all to tell you this story— where I realized I had to teach myself everything, that I had to reteach myself physiology. I know we're going to talk about detox today. But how I stumbled upon that what I'll call is the truth about detox. And so where I am today is I believe in old medicine, I believe in the body heals itself. But Western science and Western medicine is incredible. I mean, we owe much of what we know about the human body, in terms of mechanisms and pathways and how herbs even work in the first place, to Western science.

So what I tried to do is bridge the best of both, is to take the alternative nutritional functional health world, which is great for some things but horrible in others, and combine that with conventional Western medicine, which is great in some things, but horrible in others, and I try to connect the two. So I hope that gives you much of...

Lisa: That’s brilliant.

Dr. Bryan: I love science.

Lisa: And I love the way you sort of combine the traditional or the alternative with the allopathic sort of model because they do both have good things, and they do both have problems.

Dr. Bryan: Absolutely. And I can tell you, I love science. But I'll be the first to tell you that science will never prove some of the things in life—of the most important things, in relationships, in love, in health. We try to study how the brain works and I don't think we have any idea. We try to—we're doing genetic testing now, I don’t think… We talked about the microbiome, I don't think we know much of anything when it comes to these things. So, science is fascinating. It's so fun. It can occupy you for hours upon hours upon hours of reading and the rabbit hole of PubMed, but I don't think it will ever offer some of the answers.

So that's kind of where I live is that we live in this expansive universe full of all sorts of possibilities. But here on Earth, science really helps us a lot understand certain things, but it doesn't contain all the answers.

Lisa: It's a very humble approach. And I think a really good place to start because we know a lot, we don't know a lot more. But we have to sort of work with what we've got and the best knowledge. And this is something that I've really enjoyed out of like, I think I've devoured everything I could find on the internet of yours. And I must say sometimes, I'm like my brain is spinning, trying to keep up and it's fantastic. And I was talking to a colleague who's also really into you and he's got a master's in physiology and he said, ‘Well, I struggled, too, so don't feel bad’.

But you do have a way of putting things into analogies that I have just found absolutely fascinating. And today we're going to go into detoxing. And there is an analogy in this story that I've heard you speak of a couple of times that really went, ‘Aha, I get it now’. So definitely want to delve into that analogy. But so just to start with, with detoxing. Let's look at what detoxing in the public realm—if you like—in the popular—the magazines. People talk about detoxing a lot. And I think that we don't understand what detoxing is. So let's start there. What is a proper detox?

Dr. Bryan: So what you just described, that's the problem. It's a mess. I was just in the checkout line at the grocery store, two days ago. I even took a picture of my phone to send my wife and it was like, ‘A faster way to do a liver detox’, and it was some medical doctor. I thought, ‘I'm not even going to open that magazine. It's going to be garbage’.

You’re right. People say, ‘drink a little bit of lemon juice in the morning, and that's a great way to detoxify the body’. And then I was in the airport one day, and I saw these foot pads that you put on your feet to help pull toxins out of your feet. And then there's the foot pads, and there's colonics. And there's all these different things, and that's why conventional medicine doesn't believe any of this because you have these people saying, ‘Well, when you skin brush, then you're detoxifying yourself’, maybe, maybe not. But no wonder they think that we're a bunch of quacks because if you stand back and look at all that nonsense, it does look like quackery.

In the 80s, detox, the only detox there—unless you were like a hippie—in the 80s, was like a celebrity going through some kind of rehab for some kind of addiction, alcohol or drug addiction, then they would go through some kind of rehabilitation, so that was a detox. That was the only detox there was. And then all of a sudden everybody started getting on this detox bandwagon. And the thought is that we are bombarded with—we’re basically these toxic waste cesspools of disgusting that’s inside of our bodies, and the only way to get rid of it is to do these to detoxify.

Now, there's some truth to that, some truth. But our body is designed to—a better way to say detoxification is biotransformation, first of all. So there are two different types of we'll call—I don't even like the word toxins, quite honestly. You can call them xenobiotics, starting with it with an ‘x’. Xenobiotic means it's something foreign to the body. You can also call them environmental pollutants, environmental toxins, whatever you’re going to call it. Some people say synthetic, but that's not true because Mercury is toxic to the body in high amounts. So, for lack of better terms, we can call them toxins, xenobiotics or whatever. But they're things that are foreign to the body that in excess can cause damage.

There's essentially, for simplicity sake, two forms, there's water soluble, and there's fat soluble. Water soluble, by and large, I don't think we have to deal with too much, because our body is really good at getting rid of it. Our body is so much water already, we don't have to do anything to it. If we have access to something that's toxic, and it's water soluble, our body's pretty good at getting rid of it.

And when you look at the ways of getting rid of something, it's anywhere that water goes. So sweating, obviously, urinating, it's quite a bit of quite a water. In faeces, there's a small amount of water that gets expelled there. And even technically—and people have measured this but in tears or saliva, you can get rid of toxins too. So anything where water is leaving the body, then water soluble toxins are leaving as well. And I personally believe that those aren't much of a concern to us because our body... It's kind of like if you take a whole bunch of B vitamins. Technically, those can be toxic in high amounts but they're water soluble in your urine turns glow in the dark yellow if you take too much of that because your body is getting rid of it. Same with vitamin C or any of the water-soluble vitamins.

Interestingly—and I hadn't thought of this as a way of describing this, but the vitamins that they say to be careful with are the fat-soluble ones like vitamin A, D, and K because they can accumulate and then those are the toxic ‘vitamins’ if you look at conventional medicine. So fat soluble toxins, those ones are more of concern because they can get stored and the body has to work a little bit harder in order to get rid of them. In other words, you have to take something that's fat soluble, turn it into something that's water soluble, and then the body can get rid of it and all those pathways that we talked about.

So the body has built in detoxification or bio transformation processes—everybody says it's the liver but it's not. The enzymes and steps necessary for this are found in a number of tissues and in quite a bit. So, things that have exposure to the outside world, the skin has this disability, the liver does, the kidneys do, the lungs incidentally do, the testes in a guy does when we consider the location as exposure to the outside world more so than some of the internal organs. And we can go into the details of this but basically this fat-soluble toxin that can cause damage to the body gets metabolized or bio transformed, turned into a water-soluble toxin, if you will, a compound. And then is easily excretable in—again sweat, tears, saliva, urine, or a little bit in faeces. So yes, that's kind of a nutshell version of it, I think.

Lisa: Okay, so. So let's look quickly at what are toxins and what sort of a fix they have in the body? So we're talking things like your heavy metals, your Mercury's that you mentioned, your pesticides, your preservatives in your food, there's chemicals that were exposed to.

Dr. Bryan: So that's honestly—this is part of my problem with the industry is we can't even decide on what a toxin is because the toxin if you think about it, a toxin is something that could cause damage to the body. Right? So then you could say a reactive oxygen species or oxidative stress is a toxin, technically. Hormones, if you have too much of a hormone, can that cause damage to the body? It absolutely can. So, then all of a sudden is a hormone a toxin.

And so that's where we start to run into problems, is that we just throw out these terms like toxins. Well, what is that something that? Something that damages the body? Well, a hammer, if you hit me on the head is going to damage my body. Is that a toxin? Let's say, oh, it's internally. All right, well, so how about lipid polysaccharides from a gram-negative bacteria? That's an infection. Is that a toxin? Yes, it is. So that's our—aflatoxin, you have mould in your house. And so, it ends up being this really broad term that people have a hard time describing.

Now, so what I would suggest. The one that people are most talking about, that's why I think environmental pollutant, or environmental toxins, make more sense because usually what people are talking about are things that are outside of us that get inside of us and cause damage of some kind. And there's three, let's just say major categories of that there's actually more. One would be things off the periodic table. So that's the heavy metals, by and large, so aluminium, arsenic, mercury, all those types. Even copper, copper is toxic. Iron is toxic.

Then there's—loosely the category that you can call persistent organic pollutants. And that's all the ones that get all the press, like this phenol and phthalates and dioxins and all those different things, pesticides. And then there's the ones that you could call them volatile organic chemicals, or VOCs, those ones are usually inhaled. So, you paint, you’re repainting your house, or your apartment and the smell that you get, or cosmetics or toiletries, cleaning products. If you buy a brand new piece of furniture and that off gassing, carpets. So those are the— mean, there's more, but those are the three major categories that I consider so... But then you consider where those come from, in the food that we eat, in the water that we drink, in the air that we breathe, it literally is everywhere.

Lisa: Yes. So we are toxic.

Dr. Bryan: Well, yes. We are. And I long time ago would say that we're all toxic, and everybody needs to detoxify. And I've tempered that a little bit because like for example, there's one published paper that suggests—well, okay, I should take a step back—everybody is exposed, everybody is exposed, period, end of story. To prove otherwise, I would need to see that proof.

Now, it's going to be different considerably, however, based on your location, where you live. In New Zealand versus America. Here in America, I'm in Maryland, but that's going to be a lot different. I'm near farmland. So, we might have exposure to pesticides, but not so much some of the other things that might have been more of an urban area. In New Zealand there’s other different things.

So also that depends on one's lifestyle. So me and my family largely eat organic food as much as possible. We use—I don't say green cleaning products, but we use better cleaning products than just the standard things. And so we probably have less exposure than somebody following a standard diet using standard toiletries, cosmetics, yes, and all those different things too. So, we all have exposure. Yes, that's it. I think I believe that's irrefutable.

Is it stored in all of us? And I'm going to go ahead and say yes, but to different degrees. For example, you said you're a professional athlete. You have sweat a lot more than the majority of people. There's also some really interesting evidence showing that exercise actually upregulates certain detoxification or bio transformation enzymes. So you might actually be more adapted to that.

Lisa: Another good reason to do it.

Dr. Bryan: Absolutely. You know what? It’s so funny, like, you know you're supposed to, but then you just see more and more reasons. And it does, it absolutely has been shown in papers, to upregulate certain detoxification enzymes. In addition to the fact that you're sweating more so than somebody who's sedentary. So, I haven't seen any literature on this, but I believe that most athletes are probably less toxic than the general public.

Lisa: The sweat is also a preferred pathway for some of the toxins to leave the body.

Dr. Bryan: If used badly, yes. The skin has been called the third kidney before, which is kind of a cute thing to call it. I mean, is it or is it not? I mean, it's not like you're urinating out of your skin. So that should be gross. Next time you sweat, think of that. No, but it's a major excretory organ.

And I will add this, there's some really interesting, really interesting scientific papers — small, unfortunately, not a lot of money in this industry to test this stuff. But they will take a group of people, and they will test their blood, their urine, and their sweat for a specific xenobiotic or environmental pollutant. And they will find in many cases, it's not in the blood, it's not in the urine, but it is in the sweat.

Lisa: Exactly. Yes. The preferred pathway, yes.

Dr. Bryan: That's an indication that a) it's being stored and b)... Yes, whether it's a preferred pathway or not, what that means to me is that it's probably stored in the tissues. Because you think about the blood, the blood is circulatory and it's bringing things around. The kidneys are filtering the blood. So, if it's not in the blood, that makes sense, it's not in the urine. What that means is it's stored. It's if it's not coming out in the urine, that means it's not in the blood, that means it's stored in tissues. And so, it isn’t going out. So whether it's preferred by the body or not, I don't know. But that just means that it's right there, right close to the tissues.

Lisa: Yes, In coming out.

Dr. Bryan: Right close to the periphery, and it's coming out via the interstitial fluid and stuff surrounding itself. But here's another thing to consider, too, when you talked about the demographic of the population that listens to this is, while most athletes probably have less—I mean, when it gets a broad state, you can't say yes, might have less because of exercising, because of firing. But are they exposed to something more than might somebody else be?

So for example, if they're drinking out of plastic bottles that have been warmed up sitting in the sun all day, like might they have more excess pollutants...

Lisa: More BPA...

Dr. Bryan: ….these people are outside exercising in polluted area.

Lisa: Exhaust fumes.

Dr. Bryan: Exhaust fumes. I mean, you think about your respiratory rate when you're exercising, your respiratory rate is quite a bit higher than somebody who's sedentary. So then all of a sudden all those...

Lisa: And oxidative stress

Dr. Bryan: Yes, absolutely. So there's a lot of factors to consider for sure.

Lisa: Yes. So we've looked at—these are the broad categories of toxins. And yes, we're probably all toxic, and we need to be doing or thinking about doing a detox—I don't want to say protocol—but to thinking about it constantly detoxing. And you touched on the couple of studies here where they measure the sweat, they measure the urine, and so on, and they got different measurements for different things. That's one of the problems, isn’t it? The assessment criteria. Because obviously, if we're doing a detox, we want to be able to assess, are we actually getting—and when you dived into the literature of assessments in defining out which is the best—how do I see if I'm toxic? What did you find in the literature around all the assessments?

Dr. Bryan: So in the functional medicine world, there's no shortage of—well just tests in general and really attractive, good looking tests that when you look at them, you want to run them. Like, ‘Well, I would like to run this on myself. forget my patients or clients I want to run these tests’. The scientific validity on a lot of these tests is not there at all, despite what people might say or think.

Yes, so I'm not opposed to testing for toxins. But there's so many variables to consider, and the practitioners that are running them, I don't think are considering these. So I think a lot of people are using them—they're wasting their money on them because they're not considering all these variables. So, for example, the first question to ask is, ‘what tissue do you test’? Do you test the blood? Do you test the urine? There are hair tests. Technically, in the literature, they test fingernails for toxin exposure. There's so many different ways of testing–fat biopsy, you want to take a needle into your fats, take some of it out and test that.

And actually—I'll say since I said that—fat biopsies are considered to be the gold standard for internal toxic burden, and that would make sense if that's where they're stored. But the problem is, according to research—and this is done on humans, mind you—that different fat depots in the body store differing amounts of things. So, you might inject it into your, your, your butt fat, and find a whole bunch of one thing, and then you do it to your abdominal fat, and you come up with a higher amount of something else. So, if that's the gold standard, and you can't even have any consistency in the human body, then that's not going to be accurate, either. And if that's the gold standard, then that's not accurate, then none of them are going to be accurate.

So, the short version is there are some—I guess I'll say, like validated as much as you can questionnaire—subjective questionnaires that one can take and get an idea of how toxic they may or may not be. Now, it's not quantitative. It's quantitative in the sense that you get a numerical value for the score. But it's not quantitative, in terms of like, This is how toxic I am. I am 80% toxic out of 100’. It's just a subjective questionnaire. But if somebody were to take a questionnaire like this, and scores high...

Lisa: We've got a problem

Dr. Bryan: ...and then does a few detox rounds or whatever, for a few months, six months, nine months, whatever it is, and then does it again and their scores are lower, that's good enough to suggest that they're doing better. And what's interesting about some of these questionnaires, is they not only asks things like, ‘do you live around industry? Do you have exposure to petrol or to gas’? But your symptoms as well. And so it takes all of these considerations, like, ‘Yes, I live and work around a lot of chemicals, but I don't have symptoms’ versus somebody that has a whole bunch of symptoms that are associated with toxic exposure, but they don't live around them. So, it does—they really are comprehensive.

Lisa: I’d like to get a couple of the links to those if we could possibly see.

Dr. Bryan: And listen, it's free. That's the very nice thing. You don't have to spend 300 US dollars on some blood tests that may or not be accurate. And what people are really interested in is, ‘how toxic are you’? Well, if my surroundings and my symptoms suggest that I am, based on these questionnaires, that's good enough for me. And as opposed to test, if you do it six months later, and it's approved, then I think you're probably doing a little bit better.

Lisa: It's a little bit like your cell blueprint, which I found brilliant, by the way, and if anyone wants to check out that we can put the links. That questionnaire that you've developed there gives the practitioner the direction to go and we don't have a specific, ‘This isn’t definitely but hey, you might want to check your thyroid. Hey, you might want to go and check if you've got a parasitic infection, or whatever the case may be’. And I find that a brilliant system really.

Dr. Bryan: But isn't that what a practitioner wants to do? I mean, the patients come in, and they want to know, ‘Well, where should I head first’? And detox questionnaire—and again, so everybody is exposed period, everybody's exposed. Everybody has some degree of storage. Now, I don't know how much. They might be really toxic. They might be cut. Who knows? But everybody has some degree of storage. The question is, then, is, ‘Are your symptoms—because of xenobiotic exposure—are in storage or not’?

And that's where these questionnaires come in handy. If you take a questionnaire like that, and I mean, because there's people out there, believe me, there's plenty of them. Everybody's toxic, everybody needs to detoxify. There's an old book called Detoxify or Die. I mean, if that's not scary enough. It’s a good book, but I mean, it's not necessary. So we all have exposure, it's we all have some degree of storage. The question is, when somebody is not feeling optimal, Is it because of that or not?

And so you can't run around screaming ‘everybody's toxic’ because I don't know that they are. But if you score high on one of those questionnaires, then that's the direction you'd want to look into. And if you score low, I mean, listen, people will still argue it, ‘Well. We're still all toxic’. I wouldn't go down that road. It wouldn't be the first thing that I’ll thought about.

Lisa: It’s not your first protocol

Dr. Bryan: Oh, no. The questionnaires... Absolutely.

Lisa: Yes, I think that's what I do as a practitioner too, as epigenetics practitioner, and a health coach, is go for the low hanging fruit first. Because we can go in 100 directions and I can confuse the hell out of my clients and they can be like, ‘what the hell am I doing’? But if you are going for the ones late tackle, best piece of the puzzle, and then work your way up the food chain is so to speak—and actually find out which ones are the most important.

Dr. Walsh, I mean—we're going to put the links in the show notes—you've developed your own detox system if you like, which I'm really keen to share with everybody and for them to check out. But let's go in now to the actual four phases of detox: zero, one, two, and three, and you have four, isn't it? In most people—or some people are at least aware of phase one and two detox within the cell. And when I first heard you talk about this, I was like, ‘Wow, okay, there’s a zero and there’s a three’. Okay, can you explain in a nutshell, what the body does when it gets a toxin? It's in the blood for some reason, it's gotten there. What actually happens next in these detox phases?

Dr. Bryan: All right, well just to make it really comprehensive. I'll tell you, when you said when it gets into the blood, what happens? So when it gets in the blood, it can be detoxified, biotransformed, and excreted. But the best way to describe this is, so if it's in the bloodstream, wish I have something to sort of model this with but so like, so the bloodstream, and then you have you have a cell next to the bloodstream. Now there's—in physiology, there's what's called a concentration gradient. And these membranes… And so let's say we have the bloodstream in a tube—I really wish I had some kind of props here. I’m looking around. I have—my son has a Santa hat, razor blade, I don't know, I don't have much around here. Anyhow, so you have the bloodstream and here you have a cell. Now, if there's more in the blood of this, whatever it is, and less in the cell, it will tend to go into the cell. And it's usually fat cells, because it's fat soluble, it will tend to go into adipocytes or fat cells.

And so it's concentration gradient based, which also means—so that's how it gets stored. If there's more in the blood and less in the cell, then it will tend to go into the cell. And that's when it gets stored. There's a really, really cool paper that discusses how adipocytes used to be considered to be just an energy repository, but then turned out to be an organ because they excrete over a hundred different things. But one of the additional roles they suggest is that it is this. It is to store toxins or xenobiotics, or things that could otherwise damage the body—they're fat soluble, which would make sense.

Now, if that's a concentration grid. Now let's say we're in a fasted state, and we haven't eaten anything and or exposure. If there's less in the blood, and more in the fat cell, then it will leak out. And it's based on a concentration grade, it's based on homeostasis. There’s some ridiculous stories out there that will say, ‘the body won't release toxins if it's not healthy enough, and it doesn't think it can deal with them’. That's not true. What I've seen is that it leaks out from a homeostasis for a concentration gradient if there's less than the blood and more in the cell. So we are constantly leaking this stuff into our blood, if it's stored. Now this gets amplified. And I talked about this in the course, during lipolysis. So in a fasted state, in a catabolic state—not even not even losing fat, but just in a catabolic state which we go through at night. So if you stop eating at 8pm and you're sleeping, you're in a catabolic state, for example.

If you're in a state of fasting, or lipolysis, then that's going to speed up mobilization. So now—and all the studies I've ever seen on mammals or humans show this. In a hypocaloric state, or fasted state levels of xenobiotics go up in your blood. And I'll say it again because that's huge. In a fasted state or a hypocaloric state, like dieting, then if there's stored xenobiotics, it will dump into the bloodstream, and those levels go up. And they always show that every single time because that's a state of lipolysis as a catabolic state.

So then now we're back in the blood. So whether it's at an immediate exposure, or it was just released, the rest of the story remains the same. So then what happens? And I should just say too, I mean, I get frustrated with pieces of the industry. There's some people that will say, ‘Well, it's not a detox if it's not a cellular detox. If you don't detox yourself, then you're not’... This happens at the cellular level, as all detoxes is a cellular detox. So what I'm about to describe next is the cell.

So let's say we have that xenobiotic it's floating around in the blood, we either just had exposure, or it came out of a fat cell. So in one of the cells, like the liver, the kidneys, the skin that we said has the ability to do this, there are four phases of detox. So if you picture just a cube, all I have is a mug, but I have a cube. Then there needs to be a door coming in and a door coming out, that's going to be two of the phases. And then once it's inside, there's two other things that are going to happen to this.

So here's our cell, we have a fat soluble compound—I'm looking around for some—we have a fat soluble.

Lisa: It’s like your room, isn’t it?

Dr. Bryan: Well, that's the way that's why I've said it before. So yes, I mean, you could just use it as that. So in the room that you're in, or even a car quite honestly would work. So if you're in a room, you’re the cell, that's the cell, let's just say it's a liver cell. So when the door opens, that's phase zero detoxification. That's an actual phase. It was recently discovered in the early 2000s. Most people haven't heard of it but it's legitimate, things can block this. So if that happens, then that's a problem, clearly. So phase zero is when the door opens and the fat soluble compound comes into your room, into where you were.

Lisa: Into the cell.

Dr. Bryan: Into the cell, right. And once it's there, it has to go through two phases of detox. And you said I use analogies—quite honestly, I kind of make them up on the fly.

Lisa: That’s awesome.

Dr. Bryan: Well, I mean, I don't even know what I said. But I think in the past, what I've said...

Lisa: It was an angry dude—a person—we make the person a toxin who’s just entered the room.

Dr. Bryan: Oh yes. All right. I make him up on the fly until now. So all right, yes, yes, I can go with that one. So you have the room, the room’s a cell, a person is on the outside of your room, they come in, that's phase zero. And that's all it is in the cell is just a little protein tube. So the person comes in, they're fat soluble person. And they're angry. So what did we say?

Lisa: You stick a sticky note on the head.

Dr. Bryan: Is that what I said?

Lisa: Yes.

Dr. Bryan: Let’s make them more mad. That's right. Okay. See, listen, I'm telling you make it up right then and there. All right, you're right. You're right. You're right.

So the person comes in, and they will damage your room. But to incite them and make them even more angry. Yes, that’s right. You put a little sticky note, like what was your little yellow sticky notes, and you put them on the forehead, that makes them really mad. Even more mad than they were in the first place. And now you can calm them down. But if you don't, they're going to start flipping over your desk, and just totally, totally worse than they were in the first place. They were angry when they came in. But now they're even angrier. But you can hand them a $100 bill. And they're going to say, ‘All right, I was angry but now I'm not anymore. I'm good. You just handed me something. So I'll go ahead and quietly leave the room now’. And then when they walk out another door of the room, then that would be phase three.

So to put that—and thanks for reminding me of my analogy. But biochemically speaking, so you have a fat soluble compound, like a phthalate or a dioxin, or whatever it might be. So it literally has to get in the cell in the first place. Now, researchers used to think it was a fat-soluble membrane, fat soluble compound, and would just go right in. And that's not the case. It needs a channel in order to bring it in. That's phase zero, literally it is phase zero. And why is it phase zero? It was because they discovered this after they already knew about phase one and phase two, but they didn't have any numbers before then and they didn't even know it existed. So in the early 2000s, they said, ‘Well, we'll name it phase zero’. So that's the entry of a fat-soluble toxin, let's just say into hepatocyte, liver cell.

Phase one: reactions. There's a few different kinds. They’re like oxidation reduction type of thing, hydrolysis. Basically, what happens is that when in the sticky note what it had on it, it had an OH, hydroxyl group. So you put a hydroxyl group on this person, or you exposed a hydroxyl group that was already present but wasn't fully exposed. Now the problem is after we put that sticky note on their forehead, and they got even more angry is that toxin beforehand could cause damage to the body. It could cause oxidative stress or DNA damage or endocrine disruption or citric acid cycle, mitochondria, whatever was unique to that particular toxin. But now that it has OH exposed or added on to it via phase one, it is water soluble, first of all. It's water soluble, which is cool. Now your body can get rid of it. However, it's considered to be an intermediate metabolite, and is considered to be more damaging than the original xenobiotic.

Now, it's not true of every single time. And that's the thing, there are too many of these compounds to make blanket statements. People will say it's more toxic. No, it's not. It may be more damaging—I'm not going to say more toxic. It may cause more damage now that it's water soluble with this hydroxyl group exposed. But then phase two, when you handle this angry—now really angry person, a $100 bill US dollars. I wouldn't let you guys—you hand them a $100 bill or a bunch of money, they're not angry anymore. They're still water-soluble, they were but now phase two is considered a conjugation reaction and conjugation is adding something to it.

And so people that are familiar with phase two are familiar with things like methylation or sulphation, or glucuronidation, or amino acid conjugation, any of those things but what gets handed is this: so sulfation, you hand them a sulphur group, methylation, it hands them a methyl group, amino acid conjugation, it's usually glycine, glycine will go, glutathione conjugations glutathione, so acetylation and acetyl groups. So the xenobiotic gets handed to it, what's unique to that particular one, if that makes sense. You can make it really easy to talk about hormones like sex hormones, go through the same pathway—the testosterone, the estrogen. They go through the same pathway.

Lisa: They do, and neurotransmitters as well.

Dr. Bryan: Yes, cytokines, immunoglobulin, antibodies

Lisa: And dopamine and all of that?

Dr. Bryan: Yes, by and large, by and large, yes. So then it gets phased two. It gets something handed to. Let's say, it gets a sulphur group and went through sulfation. Now, it's no longer damaging to the body. Now it's relatively benign. It was damaging as its original compound. It came in through phase zero, it was made potentially more damaging by exposing or adding on a hydroxyl group, depending on what the compound was, and depending on the biochemical pathway went through, but then when it gets conjugated, it's still water soluble, but now it's not damaging. And can there—if phase three, that second door is open, can go out of the door.

Now remember, so all that does—and this is a really important part—there's a lot of misunderstandings of what phase three is. Phase three is merely a tube, leaving that cell, which means that, this thing now, in terms of physiology goes into the interstitial fluid surrounding cells.

Lisa: And it’s water-soluble at this point.

Dr. Bryan: It’s water-soluble in the interstitial fluid, and can be excreted in sweat. It can go through the lymphatic system, which is going to pick up some of the junk of the interstitial fluid but that just dumps itself in the bloodstream anyways, which that means it'll probably end up in the kidneys and get excreted out in urine. But a lot of this can end up going in—since it happens in the liver, the liver will get rid of its these...

Lisa: ...products

Dr. Bryan: ...through bile because the route from the liver to the intestines is via bile.

Lisa: Why is this not phase four, then? Like phase three should be the thing leaving the cell.

Dr. Bryan: It is, that's phase three.

Lisa: Phase four should be like actually the excretion method.

Dr. Bryan: You can call it phase—or at some point, you're going to have too many phases. You’ll be like, the 10 phases of detox. It will just confuse everybody. But after it leaves the cell, the most critical piece is excretion. And I mean, we're not talking about this part yet but I'll just say, the three pieces, there's four phases to detox. But the three things that must happen for somebody to actually detoxify, and I say must with a capital MUST, is one is they have to be mobilized. You have to get them out of the storage in first place. Two is you have to go through biotransformation, which is the phase zero, one, two, and three. The third part is they have to be excluded. If they're not excreted—and this is a really important part—if it's not excreted, it can go into another cell. That conjugation reaction that can get undone, there are enzymes that will undo that conjugation. So you handed this sulphur...

Lisa: You’re backing in the shot again basically.

Dr. Bryan: Well, and then it becomes this damaging thing again, and can get stored in another tissue if it doesn't get excreted, which, incidentally, is why I have a major problem with most fasting programmes. Honestly, most weight loss programmes in sedentary people. I mean, if you take a fitness competitor...

Lisa: An athlete’s all right, they're going to sweat it out.

Dr. Bryan: They'll probably be okay. But if you take somebody who has just been storing their whole life, they've never really exercised, they get to be 45 years old. They wear a certain weight during their wedding. Now, they're 45, they don't feel sexy anymore. Maybe it's a good time to do a real weight loss programme, the chances of them flooding their system with these things is tremendous. And if there is not an active role in, especially that's the mobilization, that's the first part.

But to properly detoxify these, and more importantly, excrete these things, then it's just going to go somewhere else. And I will say there's some evidence. It's weak evidence, unfortunately, there's not a lot of research on this, but midlife weight loss might be associated with an increased risk of things like dementia and certain chronic diseases.

Lisa: I want to sit on this topic a little bit and dive into, because I had some questions when I started to understand this whole process, it really rang some alarm bells for me. For people who do like yo-yo dieting, they're losing weight, they're gaining it, they're losing weight, they're gaining it. They're actually doing a lot of damage than somebody who's just lost it. Another thing is if you're losing it slowly over time as compared to just dumping it all because you've done a juice fast that someone told you was a fantastic detox. And then you've dumped all this into the system. And this can have impacts years later, like we just mentioned, like dementia, Parkinson's disease, all of these things.

Because I was listening to one of your biochemistry or blood chemistry lectures, I can't remember which one, something to do with cardiovascular system. And you were talking about the triglyceride molecule, or whatever you call it. And how—if the legs are broken off—it’s free fatty acids get into the system and then this can clog up the system, cause insulin resistance, be a contributing factor to diabetes, all of these things. And I was like, ‘Whoa, whoa, whoa, whoa. So, when I'm losing weight, which I think is a good thing for my body, I'm actually also doing some damaging things because I'm releasing these toxins or these free fatty acids or, or things that are actually causing trouble’.

So when we have a detox programme that's in the latest magazine, and even some of the scientific like Dr. Valter Longo’s Fasting Mimicking Diets, which is a great—lot of research gone into it, but it's looking at the mobilization, the autophagy, the mitophagy, all of these good pieces of the puzzle, but it hasn't actually considered the excretion. It does look at the micronutrients required for phase one and two, which is fantastic.

So you've got three pillars here that you're talking about. First is mobilization, of the fats or the toxins into the bloodstream from stored places, like your fat cells. Then we've got phase one and two, where it's processed, the detox—actual detox situation. And for that, we need a whole lot of micronutrients, which I want to touch on briefly like using your selenium and your B vitamins and goodness knows what. If you don't have those—your sulphur groups. If you don't have those, you're going to have trouble. And then we need to look at how do we get this stuff out. So what can we do to support the body to do binders or I don't know what the sweating protocols or saunas or whatever?

I had one question that for me personally, I've got a mum that had a massive aneurysm four years ago, and my listeners know about my story. I've just written a book about her journey back for massive brain damage. Now she's lost 30 something kilos over this last four and a half years, when I have been rehabilitating her. She does not sweat. And she's 79 years old, she's never really sweated. She doesn't do that very well, naturally. And she also now at 79, can't exercise intensively enough to sweat. I can't put her in a sauna because here temperature regulation has gone with her brain function. I have to be really, really careful, then if I make you lose any more weight, don't I? With brain damage...

Dr. Bryan: Well, it’s a hard thing to say for sure. I mean, first of all, with all that weight loss already—I don't want to say the damages—you have no idea.

Lisa: Yes, so hopefully it was not a big dump.

Dr. Bryan: Yes, so there are some interesting human studies, looking at slow versus more rapid weight loss and how much xenobiotic levels go up, and how it affects thyroid hormone, and the basal metabolic rate and all these different things to which is their recommendation is to do slower detox, but like I said, I would recommend how about, I mean start a weight loss, I would support doing detoxification pathways while you're doing the weight loss programme so that you can get rid of these things better, and it doesn't cause damage.

Yes, so in terms of yo-yo dieting, again everybody's a little different. I can't say this happens to everyone. It depends on your diet, your lifestyle, where you live, and how much you've accumulated. I mean, some people don't have a whole lot, I would suspect. But yes, so there in fact, there is at least one study that comes to mind using mice and yo-yo dieting. And what basically it showed with them is that during periods of weight loss or catabolism, that their xenobiotic levels would go up. And then when they stopped in the hypocaloric state, they went back into a more of a hyper caloric state, that the xenobiotics that weren't excreted went somewhere else. And when I mean somewhere else, like a different tissue, so it absolutely can go from one tissue. Absolutely. Absolutely.

In fact, I wanted to tell you this. Anecdotally, I just talked to a guy—I don't know about a month ago—who used to work at a water fast detox clinic in Thailand. And he worked there for a really long time. And he's said that their people would fly to Thailand to go to this water fast detox clinic that had no business to do so. They were not healthy, it's more of a novelty. Like, ‘hey, let's go to Thailand and go to the water fast place for two weeks and do a detox, then we'll go back and live our life normally like we did before, eating a bunch of garbage’. And he said, they had no business doing it, but they would come back once or twice a year. And the same people he said would get worse, that I mean, and horrible, like liver problems or teeth were falling out, and just wrecking them. And it was fascinating to hear that story. He didn't know why.

Lisa: Yes, and I can guess why.

Dr. Bryan: Well, that's what I mean is to actually have real world experience, possibly. There's no proof of this, but to see these people that would do a one week, two weeks supervised water fast and then come live their life and then come back, and their health was worse. And I think if I had to bet I would say that's probably why. And consider, it's just a water fast. So what were they not doing, is they weren't exceeding, they weren't sweating. They didn't take any binders. They weren't doing anything. All they were doing is just water. And so, to me, they were flooding their system in a very—almost completely fasted state except for water, which is essentially fasting. Flooding their system, potentially with xenobiotics, not excreting them all and then reabsorbing them, putting them in different tissues.

Lisa: Re-depositing them in your brain or something. So you could shift the mercury molecule, for example, from your fat cell where it was pretty safe. Put it into your blood and then it get redeposited in your brain and cause real strife.

Dr. Bryan: And he hasn't contacted me yet. I think he will probably be angry. But Dr. Longo you mentioned, I mean, the guy's brilliant. He's brilliant, he’s great.

Lisa: Oh, yes, no doubt.

Dr. Bryan: And it's super, super cool what he's doing, that's a huge concern that I have, though: is that you take an average person and you put them on what's essentially like, what 300 to 500 calorie diet for a period of time, and if you don't support the biochemical—so that's mobilization for sure. If you don't support the second part, which is detoxification pathways, and then the third pick is excretion, then you're potentially making them worse longer. And again, who cares about autophagy and mitophagy if you're just redistributing these xenobiotics somewhere? And it’s a huge concern. It's a legitimate one. And I’m not saying what he's done is bad, I just think it's a piece that is missing.

Lisa: A discussion needs to be had around this.

Dr. Bryan: Yes, well, and that's true of... So, take the Gwyneth Paltrow juice test. It's the same thing. You're not binding or excreting anything. You're hypocaloric, yes. Are you improving detoxification? Well, not if you have things like celery and carrots because those might actually inhibit as it turns out. So you're not detoxing. So you're mobilizing, not detoxifying and not excreting—that's bad news, I think, long term.

Lisa: Well, let's look—talk about a couple other things that are in the phase one and two, in phase three, actually, more specifically. Some of the compounds that we consider great compounds for a lot of things, like you mentioned celery and carrots. I mean, that's what people juice with. I mean, I know I just had a celery juice for breakfast. I'm not into detox, but celery in itself is not a bad thing. But it can be a mild phase three. I believe inhibitor is in curcumin, milk thistle, some of these things that we consider detox herbs, if you like, and especially in supplement doses versus food doses can actually have the opposite of fate. Can you go into just a little bit of that, what nutrients support phase one and two and three, and which one's actually inhibited? And why is it counter-intuitive?

Dr. Bryan: Well, the counter intuitiveness of it has to do with the dose, turns out. So well, and again, I mean, as humans, good lord, we've been wrong far more times than we've been right. I mean, as a husband, I can tell you, that's true. And father, it's like a daily basis. But so what we did with milk thistle was we say, milk thistle is good for liver liver detox is there for milk thistle is good for detox. And that's not true. And that's fine. I mean, that logical progression of thought makes sense, but it's not how it pans out. So it's dose related.

So, phase one. There's a lot of talk about phase one out there. Phase one are very basic, rudimentary biochemical processes. Oxidation reduction hydrolysis, if those suck in a person, detox is not your problem. They get highlighted a lot—phase one pathways. But in the end, people will say technically you need some B vitamins for this, but you need B vitamins to run most of the basic biochemical processes in the first place. So, honestly, phase one is not a phase I worry about too much in people. As long as they're nutrient sufficient, which basically means taking a good quality multi, they're probably—and I say big probably—they're probably fine with phase one. There are things incidentally, like some of those vegetables that you mentioned.

So this is where it gets crazy. In high doses, things like celery or apples or carrots can inhibit phase one a little bit. And it's dose dependent. And so it's in the concentrated form. Well, what's concentrated form?

Lisa: Supplement

Dr. Bryan: If you juice a whole bunch of carrots and apples, yes. I mean, most people will juice more than they would eat the raw fruit or vegetable. So you might juice five or six celery sticks, three carrots, two apples, and, I don’t know, spinach, Well, turns out that all those things will probably inhibit phase one in that concentrated amount. There's nothing wrong with the fruit or the vegetable eating raw. And I will say there's nothing wrong with it, juicing it either but it's all context. I'll get to phase three in a second.

Phase two. Again, these are very basic biochemical pathways that if you can't run them properly, you have bigger problems than just detoxifying. Phase Two are very amino acid driven. So amino acids make glutathione, for example. So you need amino acids just for glutathione, you need the amino acids for the amino acid conjugation pathway. Things like acetylation, you need acetyl groups, those are pretty easy to come by in the body—sulfation, methylation. So you need certain nutrients, usually, amino acids do a pretty good job supporting that.

And problem comes in phase three. So if you consider that analogy of we use the angry guy. So if you want to get rid of the angry guy out of the body, you need to have door zero, and door three wide open. So like I mean, if you consider just like—let's say you have a line of angry people outside, all you need is a sticky note and $100 note to be able to shuffle them through, right? The problem or in the body has a fair bit of sticky notes and $100 notes, not everybody, but as long as they have sufficient micronutrients like vitamins and minerals, and as long as they're sufficient in amino acids, which again, not everybody is, they’re probably okay.

Now, again, it's going to vary with people a little bit. But you need to have those doors open. And the problem really arises, and think about this, where—this is putting our whole story that we've talked about together. If that, if the exit door is closed, you can undo. You can essentially take that $100 note back, and now, it's super angry and super angry again. And so if that third, or I'm sorry, the third phase or that exit door is closed, that's where problems arise.

And so this is where it gets super interesting to me, super interesting. Curcumin, milk thistle, green tea extract, those are extremely potent phase three inhibitors. They close that exit door. And when people question me on this, well I'll show them the papers. But I'll say, ‘Look into the literature’. Because in conventional—and this is what I say Western medicine is brilliant and thank God, they do what they do, because we're learning about things that we need to use for ourselves.

So in cancer therapy, Western medicine is trying to find out how you can keep a chemotherapeutic drug inside of a cell longer, so it can interact with cancer better. And so in medicine, they talk about these pathways, because they don't want these pathways to work because then you need a higher dose. These chemotherapeutic drugs, they don't want them to exit the body. They want them in the body, so they can act against the cancer. And so you know what researchers are using to block that phase three in cancer treatments is milk thistle, and curcumin, and they're even using green tea extract and some of those types of things. They're using those in doses that people would take as a means of keeping the chemotherapeutic drug inside of the cell longer by blocking phase three.

Lisa: So this is all about context, isn’t it, Doctor Walsh?

Dr. Walsh: It’s totally context.

Lisa: We're not saying green tea is bad for you. We're saying if you were doing a detox and you're mobilizing all these toxins, don't take green tea at that time, or curcumin, or milk thistle at that time. If you're trying to do something good in the cell, go for it.

Dr. Bryan: Well, so milk thistle, I think—and I don't have a list of 10—deserves to be on a top 10 list of herbs. Milk thistle is amazing at what it does. It's so broad and all of its mechanisms. It is truly, truly an amazing botanical.

It turns out, and one of its big roles as people know is it's hepatoprotective. I mean, it can regenerate the liver. But it turns out the reason why, and this is where it really gets cool, the reason why it's so darn hepatoprotective is it blocks its own exit out of the cell. So why can milk thistle be so awesome for liver cell, because it blocks phase three, allowing you to do its other stuff to do inside of the cell longer. So that's why it's so great as a liver herb. It's horrible as a detox herb though, because it blocks phase three. And if you don't let that angry guy out, you're going to take your $100 note back and he's going to be even more angry again.

Lisa: So we need to know what you’re after, what you wanted.

Dr. Bryan: Well, one thing and understand this too. So I came at all this research in the same—where everybody else did. I was, my mind was blown by this. My eyes were open and I thought ‘Holy cow’. And just to give you an example. Well, I'll just make my statement, and then I'll tell you why. Unless proven otherwise, I think most botanicals, most herbs, most stuff don't have a place in the detox programme because people truly don't know what its effects are.

Now I'll qualify what I just said. You can take any nutrient like quercetin been studied with, there's a bunch that have been studied. And here's the problem when it comes to detox, is the same compound like quercetin will increase detoxification in one tissue of the body, like the kidneys. It will decrease detoxification enzymes in another tissue of the body, and I'm making this up, like the liver, and it will have no change on the exact same enzymes, exact same enzymes, same quercetin, same dose, different tissue or cell will have a different effect on the same enzymes.

So what that means is so you can say well, is quercetin a detoxifier or not? You say, well, I don't know because it does in one cell it inhibits at another cell, there's no change in the third. Listen, if someone wants to use quercetin, go for it. But in what I've read, in my understanding of this until proven otherwise, I don't think quercetin deserves a place in the detox programme. And I don't care who says what or shows what, when you look at the dearth of studies in that one area on quercetin, you end up like I have no idea of what a quercetin is, does it detoxify or not? I have no idea.

Lisa: So it's analytic, isn’t it?

Dr. Bryan: Unless proven, otherwise, you don't take it. So that's true but it turns out, it's dose dependent. And so the amount of quercetin that’s been found in onions, however, is probably beneficial for detox. The amount of curcumin found in turmeric is beneficial. It's helpful. It stimulates phase three, in a high potent dose inhibits phase three. Same with green tea. Like green tea as an extract in a capsule is going to cause problems. A single cup of it, I don't think but it is context. Milk Thistle, curcumin, these things are all amazing. Apples, celery, it's all amazing. But it's all about context. If you're actively detoxifying, I don't think they have a place in a detox programme.

Lisa: So quercetin is—for people who are listening, it's basically a senolytic, isn't it? Like, it’s mental health counterpart. Yes, senescent cells and things that might be useful for that. So what we're saying is that these are all great things, but at the right time, in the right context for the right person is the key. And this is the good part.

Dr. Bryan: Quercetin is step further. So quercetin blocks histamine release from a mast cell, it also inhibits the thyroid. So...

Lisa: Wow. I got—oh my god.

Dr. Bryan: You have to look at the totality. No, that's it. So, that's fine. So somebody who has hypothyroid with allergies, maybe quercing is not the best idea. But somebody with normal thyroid and allergies and possibly it will work. And well I mean, this is if you followed my work, you know I'm against protocols, but that's why. Because like one protocol will be brilliant for one and harmful for another, they're the same protocol.

Lisa: Yes. And that's why it was so great with all their blood chemistry stuff was like trying to understand the actual physiology rather than just going one plus two equals three, and therefore this person has XYZ. And to be honest, as a health coach, it’s a lot of work trying to get that into your head. It's harder than working from protocols.

Dr. Bryan: It's a pain in the butt.

Lisa: It's giving me more work to do.

Dr Bryan: That's horrible. No, it sucks. It's horrible. But I mean, listen, no. And here's the thing: as a practitioner, you can either decide—and I don't judge, I don't care what somebody does—if you want to go down the easy route and just use protocols on people and not think much, that's totally fine. For me, it's integrity. I mean, if people come to me and want me to try to help them, I will do my due diligence in trying to do so. And knowing that I can't just give out protocols, which sucks because then you bang your head against the wall for every single patient sometimes, and it's not easy, but it's good medicine.

Lisa: Can we just touch on—before, and I know we nearly have to wrap up shortly, but thyroid? How does all of this affect the thyroid? And if you need a suggestion for the next thing that you want to bring out, I need help with thyroid. The thyroid is an epidemic sort of problem and...

Dr. Bryan: And it's not easy to fix in nutrition.

Lisa: And trying to do it without, just taking levothyroxine or eltroxin or whatever isn't fixing it for most people. A lot of people are subclinical and the toxins that we’re having and the state of our hormones, estrogenic, if we’re dominant estrogen or testosterone, it's all having effect on our thyroid and our thyroid is just so important. Have you got any words of wisdom in regards to the thyroid in all of us?

Dr. Bryan: Okay, so as it pertains to toxins, I can briefly discuss that. Here's my take on thyroid. Thyroid dysfunction is very downstream. Meaning, in my opinion, it's not usually primary, it's usually secondary to something else, whether it's inflammation—I mean, who knows what. Another thing that the practitioners must ask themselves, so they have to ask themselves this is I mean, if people don't remember anything else, just remember this, is when you observe something in the body is to ask if it's on purpose.

So for example, I did a workshop on adrenal fatigue. Maybe it's low cortisol because the body wants low cortisol, and maybe low cortisol is protecting the body, and I have a lot of evidence to suggest that it is. Maybe low thyroid… So this is a thing, is it a thyroid issue? Is it something that's causing the thyroid issue? Or is it an organic thyroid issue? And if it's organic, does the body want it to be that way? Hypertension is protective in some cases, I will tell you. Insulin resistance is beneficial from an evolutionary perspective, as is PCOS. So, these are areas that I think that medicine has wrong, but...

So when you think about quickly the physiology of the thyroid. So there's the hypothalamus, it makes TRH and then the pituitary makes TSH and thyroid makes T3, T4, and there's a conversion of T3 to T4, there's binding and there's receptors and all that. So there's probably about 10 different spots. Xenobiotics, in the literature, scientifically proven, has been shown to affect every single aspect of thyroid physiology, from the stimulation of production in the hypothalamus, TRH, TSH, thyroid hormone production inside the liver, thyroid hormone release, thyroid conversion, thyroid binding, and then eventually thyroid binding on the thyroid receptors inside of itself. Every single, every single aspect of thyroid physiology is and as I say this, because it's a potent effect of xenobiotics.

So to make it clinical, if somebody is having thyroid dysfunction, subclinical thyroid symptoms, or it's showing up in a lab, what do you do? You have to be willing to be subjective and do the questionnaire. And if they score high, say, ‘Listen, I don't know if this is going to fix it or not, but you've scored high on this, it's worth a shot’. And so then you do a few rounds of a detoxification programme over the course of a few months, six months, whatever they have, however high their score was. And then have them retested. If their thyroid rebounds, then yes. I've seen some pretty crazy things with that detox. In fact, this is more of a male thing.

But I have a patient right now that reached out. Long story, really chronic guy, probably Lyme disease, just wrecked him, like neurological wrecked him so so bad. I feel so bad for him. But because of that he developed low testosterone, low testosterone symptoms, erectile dysfunction. And it's just—he's an awesome guy. I say he's awesome because he had accepted these things well. This is in his upper 30 years old, he's not even that old. But he kind of accepted it, he’ll be like, ‘This is my life. A certain amount of erectile dysfunction is going to be my life’. And he did my detox. 10 days, for the month afterwards, totally normal. He was on fire in that area. He retested his testosterone, his testosterone went up. So I'm not saying my detox does this. But what did he do during that 10 days that was able to—he had such an amazing effect. Was it the calories? Was it the food he was eating? Was it detoxification? I don't know.

So I say all that because if somebody has symptoms, do one of these symptomatic—I'm sorry, subjective questionnaires. If you score relatively high, that's the best assessment that you can do. And I would try a few rounds of doing a detox programme. If it wasn't high, I wouldn't bark up that tree. I would consider something else, some subclinical infections or micronutrient deficiency, or genes. A lot of people like to jump on the genetic train but that's a possibility as to why, too and mental emotional.

Lisa: And how we process these things.

Dr. Bryan: Yes, mental-emotional issues, absolutely. All those things.

Lisa: Yes, and the genetic some right into the whole functional genomic stuff. And that definitely plays a part in how we process things out of the body, good or not for good or whatever, and it’s part of this thing. So okay, so if we’re looking at—so the thyroid in this case, look upstream, have you got toxin exposure? If you have, well, let's look at avoidance for starters, how can we avoid some of these, clean up your house, clean up our personal hygiene products, clean up your food, organic when possible—all of these things, then we'll look at a detox.

Now, your detox programme is a 10 day programme that you can do on—regular depending on how toxic you are. And the first—sort of six days—I think it is six days is sort of based around the fasting mimicking. So a low a low calorie diet with a good mix of macronutrients to make sure that you've got all the stuff in the body to do the phase one and phase two. And what is the second part of your detox? And how do people get this protocol if they want to do it for themselves, or practitioners listening out there, how can they get this to help with the clients?

Dr. Bryan: Yes, so our main website right now is metabolicfitnesspro.com, that has all of our courses, including the detox course, there's a practitioner based one, which, I mean, that's the one I like I will say, but that that has all the science of all the paths because it goes deep into the science, basically, for practitioners. So they have a better understanding when they're talking to their patients, and they just know how the processes work. We have a more watered down version of it, The Walsh detox, that's available to the general public. Practitioners can buy that one, too, but it doesn't have as much science, it's a lot more watered down. But it's the same protocol, essentially. So yes, those are available metabolicfitnesspro.com.

Lisa: We’ll put the link in the show notes.

Dr. Bryan: So the second part of it—I mean, since recording that, I might do an updated version of it soon here. That whole 10 days was for somebody who has never done the detox type thing, any kind of dietary modification. So just consider the average person, you know who they are, who’s never really done much with their diet, minus trying to lose weight at some point.

For people that are more experienced with dietary modifications, that are probably a little bit healthier, going into something like this, like yourself. What I have been doing with people is we will do instead of one 10-day detox and a month, we'll do two of the latter half. So two 4 to 5 day, if that makes sense. So it's really just fasting mimicking diet. So it's five day the more intense version, but we'll do those. So first week, and third week in a month, we might do five days of that. And that's arguably the more...

Lisa: Practical

Dr. Bryan: Well, a potent part of it, too. Yes, it's more potent than the ones with the mung beans and all of the things in the protein. So there's a couple ways of doing it, but it just—again, it depends on where somebody is. We've had people with multiple chemical sensitivity, that didn't feel real well, and they had to modify their program, more binders, more foods, so they weren't as hyper caloric, longer saunas at a lower intensity. So it's not a protocol, it's principles, if that makes sense. They are modifiable depending on somebody. So somebody like yourself, I wouldn't bother doing those first six days, I would just do the last four days a couple of few times a month, if you wanted to.

Lisa: Yes, and keep processing the stuff and it really is just final on the binding. How can we help our bile, like bind up our bile, and some of the things that we can excrete, the sauna you mentioned is a great thing. Exercise and sweating and sauna. What about laxatives and diuretics and things? Are they bad? Because to help once you've got the stuff out to get it out or binders like activated charcoal, chitosan.

Dr. Bryan: So those are on the programme. Well, and here's the other thing, there's so many, I think garbage detox programmes out there that I wanted to try to make what I thought was the first truly evidence based one looking at the scientific literature. So there are binders that exist that I didn't include, because I couldn't find any literature on them like zeolite or bentonite clay. I love them. I think they're great but I couldn't find literature on it.

Things like charcoal, chitosan or ketosan, however, you want to pronounce that, fibre, soluble insoluble fibres, modified citrus, pectin, they all have some evidence behind them that they actually either increase bile excretion, or when they increase bile excretion, increase xenobiotic excretion as well, which is faster, that's what we're after.

So you ask a really good question. What, somebody’s liver health going into this? What is their bile production going into this? What is their bile going into this? Yes, all that stuff. So I've been meaning to do sort of a follow up to that programme because I have like a phase two of that where you can modify some of these things.

Lisa: For difficult patients.

Dr. Bryan: Well, yes. So kind of—I mean, it eventually puts all this stuff together. So you're doing the blood chemistry stuff you said. So like, if you determine that somebody has fatty liver, they probably don't have very good bile flow, and they may need some additional nutrients to do a detox that you don't or I don't know, or probably most of your listeners don't. There's pH comes into this as well, which is kind of a big piece when it comes to the kidneys and whether they reabsorb things or not. But just the fundamental principles, is designed to help somebody who's relatively healthy do a good detoxification programme and see results. If somebody is particularly unhealthy then there are some modifications that would need to be made.

Lisa: That would be a great update to the whole thing. Yes. For people like in mum's case, no gallbladder, liver enzymes. Not too bad, but they're not the greatest, all of those sorts of aspects. But I mean, it's going beyond today's discussion.

Dr. Walsh, thank you so much for all the work that you do in this area. It’s absolutely mind blowing. It's opened my eyes to a lot of things. I really hope people go to metabolicfitnesspro.com. Check out Dr. Walsh's detox programme, but not just his detox programme. If you are a practitioner, there is a whole lot of education stuff that you can—I have a lot of colleagues who I talk with and Dr. Walsh is a hot topic. He is a hot topic. Everybody's learning from Dr. Walsh. So people out there listening, if you want to get it from the best, if you want to know what's really in the literature, and you don't want to sift through PubMed for months on end, and do it yourself, which I really don't have time to do. Then, I'd rather get it from someone like Dr. Walsh.

So, thank you so much for your time, Dr. Walsh,

Dr. Bryan: My pleasure. Thank you.

Lisa: Thank you very much.

Dr. Bryan: You, too.

That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends. And head over and visit Lisa and her team at lisatamati.com.

Download this Episode

Understanding Stress for Better Stress Management with Neil Wagstaff 0

Dec 10, 2020

In this fast-paced world, it seems the only way to move forward is to push harder and harder. But where is this relentless rat’s race taking us? Never has there been a higher prevalence of chronic disease and mental health disorders globally. If we want to change this dynamic, we must understand that rest, recovery and effective stress management are equally important in driving results.

Neil Wagstaff joins me in this episode where he explains the science behind stress. He outlines the various stages in the stress curve to help you identify where you might be in the spectrum. We also talk about the importance of awareness. With a better understanding of stress, it’s possible to make small lifestyle changes to reduce its toll on you and take greater ownership of your health.

Don’t miss this episode if you want to develop your resilience and learn effective stress management!

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Here are three reasons why you should listen to the full episode:

Understand stress better by learning about its symptoms.
What is homeostasis, and what are the stages of stress?
Discover the importance of awareness in stress management.

Episode Highlights

[03:15] Defining Stress

Stress is a normal part of life. It can be good if it’s used in the right amount.
Picture stress as a bucket. When the bucket is filled in too quickly, it can overflow.
With proper balance, stress can be managed, and you can avoid the bucket from tipping over.
The Goldilocks Principle shows that the amount of load or stress we put on our body should be well-balanced to get a positive result out of it.
Stress should be balanced with recovery to get optimal results.

[11:59] Symptoms of Stress

Feelings of depression, anxiety and anger start to rise in times of distress.
A weak immune system reflects stress in your body.
Stress happens when there is a lack of balance between work and recovery, when there is a lack of resilience.
Take the time out, time to reflect and to show gratitude so you can move forward.

[20:13] Health and Homeostasis

The goal is to maintain homeostasis, when the body is well-balanced and stable.
The alarm stage usually comes after experiencing homeostasis, especially when you’re anticipating something new or big in your life.
This can bring about an arousal of emotions, which can be overthrown using stress management techniques.
Being always on the go can lead to chronic mental health problems like anxiety and depression.
The key to maintaining homeostasis is giving yourself time to recover.

[24:16] The Resistance Stage of Stress

After the alarm stage comes the resistance stage, where you actually put stress on your body. It is when you can feel really stuck.
This stage can result in a chronic state of exhaustion.
This puts you in the position to address the stressors by changing habits, perceptions and behaviours to bring back homeostasis.

[26:41] The Exhaustion Stage of Stress

This stage happens when your stress peaks and things get out of control.
We want to prevent reaching this stage as much as possible.
Stress can activate the body’s fight or flight response, which can have a negative spiral effect on the body, both physically and mentally.
It is crucial to bring awareness to your behaviour and decisions when in the exhaustion stage to avoid spiraling down further.

[31:41] On Awareness

Increasing our awareness around stress and personal wellness has made a big difference on the things we do.
Individuals with lower awareness tend to externalise their problems and not have control of their lives.
The greater your awareness, the more likely you are able to take ownership of your problems and control your mood, health and how you look at the world.
Awareness is also vital for teams. It allows you to help your teammates and prevent things from spiraling out of control.
It starts with being aware, but you don’t have to tackle your problems all at once. There is no instant fix, not even coaching.

[36:16] 7 Questions to Increase Awareness

What is the biggest stress you have at the moment, and how is it expressing in your body?
What normally causes stress for your body?
How is stress showing up — does it come in certain environments?
When is stress showing up?
What can be done immediately to alleviate the feeling and support your biology?
What can you do to manage your stress response better?
Finally, what are the long-term strategies you can implement to lower your residual stress?

[42:36] Stress Management: Start with the Small Things

Look after your stress like you look out for your body.
Do any mobility work (or breathing work) that is right for your biology.
Spend time with nature.
Perform habit stacking or the art of doing simple things to get complex things done every day.
Start doing things in practice to increase your awareness.

7 Powerful Quotes from This Episode

‘...the resilience is found in rest. But society will say to us that resilience is found in pushing harder, pushing, doing more, doing more and doing more, but it's found in rest’.

‘So this is why it’s important to remember, in daily life and business, you need the recovery aspect in there. It should be like a training program’.

‘Finding joy in something is the real key to my mental balance. I’m not being selfish when I take half an hour to paint a picture. I’m not being selfish — I’m being sensible, and I’m looking after my own health, and therefore, the health of my loved ones’.

‘Sometimes the answer isn’t actually just addressing what’s under your nose and addressing your work. It could be addressing your food, your movement, how you’re looking after your mind and all those things. And then change your perception of work totally so you can manage it a whole lot more effectively’.

‘It's really important for corporate teams or sports teams to start recognising signs and others. And if you are more aware than the other person, then you can help them more… so that you can actually prevent things from spiraling out of control’.

‘If you find yourself blaming everybody else for the situation, then you're probably not very aware of things that are going on because you're just externalising. If you're moaning a lot… Then you might want to have a look at the way that you're actually processing things and understanding things and take more ownership’.

‘You don't have to tackle the whole thing at once. But it's being more aware. Am I a person who goes through life blaming everybody else, blaming the system, blaming that? Or am I someone who does something about it, takes ownership, starts to make a change in [my] own life’?

Enjoyed This Podcast?

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Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn more about effective stress management.

Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube.

For more episode updates, visit my website. You may also tune in on Apple Podcasts.

To pushing the limits,

Lisa

Full Transcript Of The Podcast!

Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati. Brought to you by lisatamati.com.

Lisa Tamati: Welcome back to Pushing the Limits this week everyone. I hope you're having a fantastic December. Can't believe we're already here, Christmas is just around the corner.

I have an interview today with Neil Wagstaff. He's a repeat offender on this show. And I love having my business partner and my coach, exercise, science men, Neil Wagstaff with me. And we're going to be talking resilience and stress, how to control stress, how to understand what it's doing to your body, and some of the techniques and things that you can do to cope with stress. And I really hope you get benefit from this episode.

It's an ongoing theme. We have lots of stress in our lives generally. We live in stressful environments, we've got families and financials and sicknesses and illnesses, and all sorts of things that we have to deal with on a daily basis. So here's some really good advice and tips around managing stress and being resilient.

Just before we head over to the show, please give the show a rating and review if you enjoy it. And make sure you share it with your friends and family. And if you're looking for stocking fellows, make sure you head over to my shop on lisatamati.com, my website. You can check out my fierce jewelry collection, there you can check out my books.

And of course, if you are having trouble with any sort of health issues, or you've got a big goal, or you want to deal with some mindset issues, I am taking on a very, very small number. I've pretty much meet the quota. But I've got a couple more spots left. If you want to work one on one with me reach out to lisa@lisatamati.com. And I can send you information about my health optimization coaching.

Okay, now over to the show with Neil Wagstaff.

Lisa: Well, hi everyone, and welcome back to Pushing the Limits this week. Today I have my wingman Neil Wagstaff, with us again. My gosh, you're coming on the show a lot, now, Neil.

Neil Wagstaff: Like you make me feel really popular, man. I love it.

Lisa: It's really good to have you here because you just got so much knowledge. And it's just fantastic being able to share all your knowledge with everyone out in podcast land. So if you're a new listener to the show, thanks for dropping by. And if you're returning listener, thanks very much for coming back again and please don't forget to give us a rating and review. We love hearing from you guys and you reaching out.

Now today, the subject is stress and how it affects your body and health. A big topic for so many people, especially given 2020, it's been a disastrous year on many, many fronts for many, many people. Certainly been the worst one of my life. So we're going to talk about how to deal with stress, how to recognize the signs and symptoms of when you're getting overstressed, how to just to manage your physiology so that you can get the best out of your life without tipping yourself over the edge. So Niel, over to you. More to say what’s it all about.

Neil: Firstly, it is a normal part of life, it is definitely a normal part of life. And it can be good. It's often given a very negative, negative sort of press and people see it as a negative thing. It can be that definitely, but it's also something we need in our daily life. And something we want—you and I personally we thrive off it and love having things to do, we love being busy and love getting things done. So that's good.

For some of the good stresses that people be aware of when just understanding they're putting them into that stress category is these things will have an impact on our body and can put load on it. And therefore they're putting load on it they can cause inflammation and effectively cause stress of some sort. So exercise is a stress and it's a very good stress if it's used in the right amount. Okay? It can also be bad stress.

Lisa: Dosage.

Neil: Yes, exactly the right dosage. Food can be a stress and it puts a load on our body. Again, use well, it's a good one. Work, again, manage well with good balance is a great stress to have and we all should enjoy doing it. Mental challenge can be a good stress. You like being pushed to our limits, you're definitely a great example of someone who loves pushing the limits, Lisa.

Lisa: Yes, mentally and physically.

Neil: So there are good things in that. New environments, new experiences. They're all great stresses that you can put on your body. General ones on the bad list would be things like poor sleep, and lack of exercise, social stress, prolonged challenge—the stuff that goes on for too long without rest and recovery. And then significant physical or mental trauma as well.

Now if you manage those two buckets. We often talk about the bucket of stress and you have heard us discuss that on previous podcasts as well. But these things, if they're thrown in the bucket, and the bucket gets too full too quickly, then some things on the good list can actually be the things that actually cause the overflow and cause too much stress. But manage well, manage those lists well, and you're going to be in a position that is part of normal life, it should be good. Stress needs to be there. The key thing is that you've got balance with it. And that's what we'll go on to talk about a little bit more, a little bit more today.

Lisa: Yes, so I think things like exercise people don't often recognize as a stress and it can be added into that same bucket. And we have talked about that principle before on the show, where, that can be the stressor that tips it over, if you've already got a very full bucket. So even though you think, ‘Oh, doing my training today is a good thing’. It is, if your body's ready for it, for example. And if you've had a lack of sleep and lack of social interactions and your food was crappy, then that extra stress of exercise, or doing it too hard on that day might not be a good thing. So it's about balancing it. And it's about recognising when your body is in a state of excessive stress.

So now we're going to talk about the Goldilocks principle. And I love the Goldilocks principle, it's pretty much a metaphor for everything in life. The more I study biology and chemistry, the more I start to understand that everything in the entire world is all about the Goldilocks principle. Not too hot, not too cold, not too much, not too little. Just getting it right. So how do we get it right, and what is the Goldilocks principle in regards to stress, Neil?

Neil: What you said, is so true, Lisa. It is so appropriate to so many aspects of life, it really is. One of the examples we often use is quite an easy way to look at it, it is looking from a training perspective, and especially from my background, that's what I understand well.

So when someone goes through a training program, or an exercise program, goes through rigorous exercise classes, you don't want to create a training stimulus in the body. You want to create a effect on the body under load. So you're going to cause some stress, it's going to break it down, so you'll get a response. And it comes up after a period of time and it could be sort of that four or six week period. We then start to get some great results. Otherwise what’s known as super compensation, where your body compensates and responds really well.

Now the reason it does that is because you've put the right load on it. So you put the right amount of stress from an exercise point of view, therefore, you're going to get the nice result at the other side. Now if we do put too much—or sorry—too little stimulus on the body, then the result is going to be smaller, and we won't have such a great result at the other side and four to six weeks time. If we put too much stimulus on, which we see a lot of people doing in our work, and not enough recovery, and you don't get any results at all.

Now stress works in a similar way. And what we're looking at in this example is we want to put stress as in the exercise load on a body to get the result. But in our daily life, should be a similar process. The amount of load we put on our body each day should be enough that we get a great result at the other end.

And we had a, Lisa and I were away doing a court presentation about a week or so ago. And we had a great discussion there with one of the one of the team we're working with. And he gave the example of in sport like I've just given, you've got the chance to recover. Now in business and daily life, you don't often get the chance to recover. So you have these periods which becomes longer and longer and longer, where you're putting yourself under excessive load to get a result. But you missed that super compensation because the amount of load you're putting on means there's no recovery and that means that the result you get it, but you get it it's such a hopper that after a long period of time you end up burning out, and that's what we want to avoid. So this is why it's important to remember there in daily life and business you need the recovery aspect in there, it should be like a training program.

Lisa: And there was a really good example last week. High end executives really pushing the limits on a business point of view and in doing that day in day out, year in, year out and leading—but leading to problems. And this is a societal problem where we all under the pump all the time, or a lot of us are. And that does lead and it's trying to manage your—the physiology because our physiology is still old. And the fact that it’s ancient, our DNA hasn't necessarily evolved to our current lifestyle and so trying to manage this as best we can to get the best results.

Now talk about super compensation, I did a really hard CrossFit workout yesterday, and I've got very sore ass cheeks today. So I'm not going to go and smash myself again today, and that because I want that super compensation. The fact that I have sore muscles, sore glutes, and sore legs means and I caused a training stimulus. So right now my body is weaker and I need to give it a bit of recovery, and recovery might mean doing a bit of yoga today and a gentle walk and maybe a light jog. But it doesn't mean going and smashing myself again today because that will likely lead to a negative adaptation. And I want to get the most out of that painful workout yesterday. So I know to back off a little bit today.

And that's what hold training plans are about—getting that combination right and that periodisation right for your particular goal. And that's what we do with Running Hot, with all our athletes that we're training is periodisation. So that they peak at the right time, and they get the most super compensation and not the negative adaptations that can happen when you start to go into that overtraining. And it's quite counterintuitive, isn't it? Because as athletes, you just want to go hard and go hard again the next day and then go home. You've had a sleep, you've had some food, you should be good to go again. But you do need that recovery time, both on a 24 hour hourly basis, as on a monthly basis, as on a yearly basis. So we're going to talk a little bit about that as we go through the session. These are micro and macro cycles we're talking about. So let's talk a little bit about this and what it is to get this just right? And how important the accumulation of stress can lead to your downfall? And why resilience is really found in race?

So what are some of the symptoms for somebody, either as an athlete, or as a corporate athlete, or someone who's got three kids and two day jobs, what are some of the signs that that stress is starting to take a toll on their physiology and on their psychology as well?

Neil: For mental health point of view, we've got people on too much load and too much stress is where depression will start to come in—anxiety, anger. And those feelings, the risk of chronic disease goes through the roof that just jumps up, jumps up massively and puts more load on the body, and then the immune system just starts to drop as well because that additional load, there's no rest on the body.

On the flip side, if you've got the balance just right. So we're talking about that super compensation, you're getting the balance, right, so you're getting that result, then you're going to feel calm, you're going to feel more proactive. There'd be lots of growth and recovery. And from a health point of view, your health is optimised, and your immune system’s strong.

Now, a lot of people we're speaking to in the trap of going hard, going hard, going hard, it’s going hard. And then we get those feelings of anxiety, anger, depression, and more disease issues. As we work through people's blood with them, we're seeing higher risk of disease when we're looking at bloods now than what we have done in the past, which has a bigger impact, obviously, on immune system and future chronic disease as well.

So taking in those and listening, you will have found those times in life where you felt that productivity was good, you felt calm, there was good growth, and you feel on point. I guarantee you, when you look at those times, you'd have had good balance, and you've had enough rest and recovery in the day, in the week, the month, the year. It means that you're getting those benefits you should from a stress management point of view. And some of you listening as well will have experienced the others and most of us—Lisa and I have at some different points in life, where you experienced the anxiety, the anger, because you've got the balance wrong. And that's an easy—easy is the wrong word to use. But once you understand that, it is an easy fix to make.It's just understanding the how to make the fix so you get the resilience.

And as you said earlier in the exercise example, it's counterintuitive because the resilience is found in rest. But society will say to us that resilience is found in pushing harder, in doing more, doing more and doing more, but it's found in rest. And that's where a lot of the happy feelings and emotions are found as well, by taking time out, time to reflect time to show gratitude, and to allow you to move forward. And at the end of the day it's in—you've used this example recently as well, if you haven't been healthy.

Lisa: You got nothing. You have zero.

Neil: Exactly. So you need it.

Lisa: Yes, and I think like that depression, anxiety and anger part of the puzzle. So these are all your neurotransmitters that are at play here. So your dopamine, your GABA, your serotonin, your adrenaline, your cortisol, all of these things that are actual chemical things in your body causing you to feel a certain way.

So when you see yourself—and I mean this is definitely talking to me here. When I see myself getting irritable and angry and snapping and being anxious about the future, then I know, “Hang on.” And Neil will say to me, or my husband will say to me, ‘Hey, you're getting out of control again’. And I’m like, ‘Well, okay, I need to take more time out’. And just sometimes like taking a couple of hours out for yourself is not being selfish. And I really, really struggle with this one because it's for me, it's like a guilt, ‘But I should be doing this’, and ‘I should be doing that’. And I've got a billion things on my to do list. And so I hear the people when they say, ‘But I haven't got time for that’. It's like, yes, but do you want to be an asshole to your friends and family?

Like, if we get down to it, that's what happens, and depressed and miserable and losing the joy of life. When you don't have enough GABA, which is one of your neurotransmitters, and you don't have enough serotonin in your body, that's what you're going to feel. You're going to have lose the love for life, you're going to lose the love for your passions, that your hobbies, you're going to like—not be interested in them anymore, you're not going to have that dopamine hit where you want to get up and go and you're motivated to drive towards something.

So when you feel that those neurotransmitters are off, by just backing off the accelerator pedal, having some time out to do some health and self care, like I love getting into a sauna, or going for a walk, or doing some stretching, or doing some meditation, or breath work for me is huge. All these things help me manage my emotional state and help my body recover. And we often think that, ‘Ugh, I've just got to get over it. And I'll have a good sleep tonight, and I'll be good’. But if you're not giving your body, the right ingredients, the right nutrients, the right time out and play, then you're not going to have the right combination of neurotransmitters running around in your body. And no matter how much willpower you have, you're probably not going to have a positive outlook on life. And it's something I've really had to learn the hard way.

Now, after going through a very stressful few months that I've been through with losing my Dad, I've had to prioritize just doing something I love. And for me that might be—I'm into painting at the moment, following my dad's footsteps, and that gives me joy. And finding joy in something is a real key to my mental balance. I'm not being selfish when I take half an hour to paint a picture. I'm not being selfish. I'm being sensible, and I'm looking after my own health and therefore the health of my loved ones. And that does have an effect on our people around us. And none of us want to be that horrible person that's grumpy all the time. It's not much fun. So.

Neil: Definitely, it’s a great, great example. And thing as well, as people are listening is understanding that what is worked for you won't necessarily work for everyone and vice versa. So it's finding your thing, and your rest and relaxation, self care, it's going to be different for each person. And if you try things, and they're not working for you, resonate with you, then try something else. And once you find your sweet spot, like you described the painting, then you will find those feelings. So, I wouldn't necessarily get it from painting, just because I can't paint.

Lisa: Neither can I.

Neil: There’s other things I definitely get it from. So it’s understanding that you find what's your sweet spot, and what's going to have that impact on your body. Once you understand that, then it becomes a lot easier to do.

Lisa: And don't think you're being selfish because you're doing it. That's the real key message and trying to prioritize us because it's like where the corporate executives last week. You have to perform. Yes, but underpinning your performance is health. So if you don't have health, it shouldn't be something that you optionally do on the side, it’s one of the things you get around to, it underpins everything.

So this is part of your health, regime, your practice. And if you see health and looking after yourself, and that's nutrition, that's fitness, that’s all of those things. If you see that as the foundation on which to build your house, that's a different approach, than to seeing it as a pillar on the side that you want to get around to, that you never do get around to.

For Neil and I, it is fundamental. It is our priority. It is also our business in our case. And we can't be good examples to you guys if we're not performing the best that we can and looking after ourselves. And just reprioritising—having those conversations in your own head is about, ‘it's not being selfish, this is being sensible’.

So now, I'm going to talk a little bit about the stress curves and the phases that you go through from good health and homeostasis, right through the exhaustion stage. Neil, can you explain this concept a little bit?

Neil: Yes, so we look at different stages as we go through the stress curve. So if we're looking at homeostasis, as you saying good health, this is when the body's in balance, and it's stable and hasn't been pushed, there's no stress on it. And we've got in a calm, there's nothing that changes, changing the environment. So that'd be a nice place to be all the time. But most of us would get bored quite quickly, and would generally get anything done. So good space to be for your body but that's the sweet spot. So we want to spend some time in that. And we want to spend ideally some time in that each day, each week, each month, each year, so we manage those peaks and troughs.

The alarm stage, which comes next is where we start thinking, readying ourselves for the future. So this is where we've got heightened awareness, increased speed of thinking, higher attention, and generally a higher state of arousal. Nothing's happening yet, but we're readying ourselves for this. So this one of Lisa’s example, could be getting ready for a marathon, or a race, or a running event. It could be getting ready for a big, big meeting, or big presentation where you're preparing yourself for it. You've been going through the process, your body starts, the blood pressure will go up, heart rate will go up. You get a physiological response going on in your body to prepare yourself to what's to come.

Now that's healthy, if you're not in it all the time. Okay, so that's healthy, it’s good if you're in all the time, we want to be able to ready ourselves for that. Where we're seeing quite a lot of problems at the moment, as people aren't coming out this, they're always on.

Lisa: Staying on the alarm stage.

Neil: They’re always on, they’re always switched on, they're lively. They're always twitchy and ready to go. And if you don't come out of that, then your body's not going to have the chance to recover and you're going to start to get—from a physiological point of view, those stress hormones flying through your body at a great speed. And that's what starts to put more problems on the body and problems with health. And that's where we see more issues with chronic disease and where we see bigger issues and those feelings of anger, anxiety, depression, and mental health.

Lisa: Mental health. I mean, I've got like an example there with just being open about my life with going through the drama with my dad and losing him. And being in that alarm phase, where we're fighting for his life for a couple of weeks in hospital and going harder, harder, in that absolute. I was in the alarm stage, and then the next stage, which is the resistance stage, where you're actually in the doing. And now we lost the battle, in that case.

And now, the anxiety that comes with being in that state for a few months, means that my body needs a massive amount of recovery right now. It doesn't need to be smashed and smashed with really high intensity workouts constantly and I'm slowly—but rebuilding, but it's the understanding that that's had a trauma on your life. And that has led to a very bad state of affairs, as far as all your exhaustion, all your stress hormones were concerned. And if I don't do something about that now, what that could lead to as real big health issues.

And I saw this when I went through it with my mom, four and a half years ago with her journey. I went hard out for the first 10, 11 months like to the point of like, absolutely blind myself to pieces, and I had to because she needed that. But then my body shut down, and then I was in and out of hospital. And I was in shit creek basically for the next year because my body was in that exhaustion stage, which is what we're going to talk about next. And so it's understanding—just as that's an example of my life, but we are going in and out of these stages on a daily basis, but also on a weekly basis and on a monthly and yearly basis.

So we just talked about the alarm stage where you're ready for action, but nothing's actually happened yet. So you're all anticipating and then you're in the actual resistance stage, which is the doing part of putting stress on your body. So you're taking action, you're making your body adjust and cope with the environment and you're in the fight. You're using the fuel and your body is resisting the stress. So this could be doing a workout. It could be situations like I was in, this is where you're going under slipped, maybe you're tired, you're pushing through, your stress hormones are very, very high. And this is a stage you can also get really stuck, isn’t that Neil?

Neil: Yes, it's spending too long here as well. A good example where we see too many people doing it is—I was having this conversation, someone today is just not getting enough sleep. We've all done it where we've had deadline at work or lots going on, but so many people are pushing it further and further and further now. So even though you're tired, you push through, using your stress hormones to stay on it, and there comes a point where your body will just stop producing the stress hormones as it should. And then you're really into the neutral phase. And that's when you start to get the risk of the chronic disease and the other feelings that we talked about—anxiety, depression, and the mental health side of things.

Lisa: There is a reason why chronic disease is just going up exponentially in society today, I mean that and toxins and environment and all that sort of jazz and food chains. But one of the big problems is this chronic state of exhaustion all the time I think, so that actually...

Neil: To add to your point earlier, you shouldn’t add the other things in it like poor food. You then add pollution, you add in toxins we've got around us.

Lisa: Heavy metals.

Neil: All of those things have all increased, and they've increased massively over previous years. And we're looking after our bodies less than we ever have done. So now we're in a position that they add those other things on top, and all of a sudden, the load just comes more and more and more.

So it's been where as well—where your stress is coming from, like we spoke about the start. It could be that simply by changing your eating habits, or the time of day you're eating, and what you're eating, and when you're eating, all of a sudden, that actually takes a load off your body. So you manage your work a whole lot more effectively. Sometimes the answer isn't actually just addressing what's under your nose and addressing your work, it could be addressing your food, your movement, how you're looking after your mind and all those things and then change your perception of work totally. So you can manage it a whole lot more effectively.

Lisa: Yes, absolutely. So the last stage that we wanted to talk about is going into the exhaustion stage, which is what we just explained, Neil, where you're absolutely been on the go for—God knows how many weeks, months, years, and your body is starting to shut down. And this is where you are starting to get chronic problems, and serious ones.

And this is the phase you don't want to get into because this is where you're going to be set on your ass, whether you like it or not, where your health is going to go down like mine did. And you will be forced to take a break. But we want to prevent that whenever possible. I mean, sometimes life is just going to throw a curveball at you. But if you understand this process, and you can perhaps stop getting to that exhaustion stage and understand that those stress hormones, I think most people think, ‘I've heard stress is bad for me. But how is it bad for me’?

Well, if we just go back, and I have talked about this a couple of times, but your parasympathetic and your sympathetic nervous systems, you've got these two systems, your rest and recovery and your sort of go-go-go state of affairs. And that sure is sympathetic, and most of us are sympathetic dominant. We're not having enough time for that rest and recovery, and our ancient biology is just really not keeping up.

And when you are in that fight or flight state, and you've got lots of cortisol and you've got lots of adrenal and you're taking energy away from your immune system, you are taking energy away from your digestive system, you're taking blood flow away from different parts of your brain, so you're not unable to make good decisions. You're unable to digest your food, and then you're affect your absorption. And that can affect your thyroid and it can affect your immune system, and on and on it goes.

So this is how stress actually has a physical effect on the body. It's not just a mental thing. I think people think often it's just a mental—under stress as a mental—no, it's very much a physical reaction of the body about where the body is putting the resources. You have a limited finite amount of money in the bank, or energy in the body, and their body is going to prioritise the areas that are most important.

So if it thinks that you're running away from the lion, it's going to put all the energy into making stress hormones, to making sure your blood is in your muscles so that you can run and you can fight. It's not going to be—in helping your immune system repair. It's not going to be in fighting infection. It's not going to be digesting and this is where the resources are being put. So it's like you spending all the money that you earn from your job in one particular area of your life and not paying the mortgage. That's what's happening. And you need to be paying that mortgage otherwise you're going to lose the house. That's a really good analogy, actually isn't Neil?

Neil: Yes, it’s a great comparison. And it brings us back to where we were talking about the start is where you're allocating your time to. In that example where you're allocating your money to, but if you're allocating all of your funds, all your time to one particular area, then something else is going to suffer.

Lisa: It's going to crash. We like to think we're superheroes and Neil you’re very, very close to being a superhero. But we're not really, we’re not really both.

Neil: Thanks. For me, I’m a little bit of one.

Lisa: Yes, for your kids.

Neil: And understanding as well that these different phases that we've just been talking about. You can go through these levels in one day, which was what we call a micro cycle, or you can over a longer period of time, months, years—go through them as a macro cycle, so a bigger cycle.

So we've talked about what happens if we stay in these phases, each of these phases too long. And Lisa has given some real good examples from her life is what does actually happen, from a mental and physical point of view, as well. So the fact that you can go through them each day, the exciting thing about that is you can put yourself in a position that you can control them each day. So you might feel like it's a big mountain to climb. And you've got to do a lot before you can get a grip of it. But you can actually make some quite significant easy changes each day to mean that you can start going in and out of these.

And sometimes just little micro rests, small rests, small windows opportunity where you actually can switch off the body, switch off the mind. And again, different things work for different people. But once you find your thing, start doing more of it because this will get you longer results in work, family, and sport as well. It applies to every aspect of the puzzle.

We talk a lot as well with getting people become more aware of themselves. So when we talk about awareness, we will look at the load that’s going to put on people's body. And I know that this has made a big difference that hasn't at least just been increasing our awareness around stress and our own personal wellness. And as we've increased that, it's made a big difference to what we're doing. And generally, we've seen those with lower awareness will generally tend to externalize their problems more, lose control more, the factors influencing their mood in life, and often will blame others more—it's someone else's fault, someone else's problem.

The greater awareness is, you’re more likely to take ownership of our problems, more likely to deal with them, and control our mood or health and how we look at the world. So it puts us in a much better position. Generally as well, we've seen that awareness will increase with age, although this isn't always the case.

Lisa: Not always.

Neil: Not always the case, the increase in experience. So as we've dug deeper into the science of what we do, how we do it, is definitely increased our awareness to the point that as we've experienced more things, coach more people through these things, our perspectives changed and as well, the way we self-reflect. And that's all led to low levels of stress because we've now got a better understanding of what's going on, why it's going on, and what load is having on our body so we can do something about it.

Lisa: And we can look after each other better, just as business partners, right?

Neil: Great point. Great point.

Lisa: It’s really important for corporate teams or sports teams to start recognizing signs and others And if you are more aware than the other person is then you can help them more and that is your responsibility then to be aware of other people and their needs around you. So that you can actually prevent things from spiralling out of control, and support each other a little bit better. And back off when things are getting tough for somebody and push a bit harder when someone needs a kick up the jacksy. So it's all about helping others and being more aware.

So if you find yourself blaming everybody else for the situation, then you're probably not very aware of things that are going on because you're just externalizing. If you're moaning a lot, ‘Well this is shit and that is shit. And my boss's this and my things that’, then you might want to have a look at the way that you're actually processing things and understanding things and take more ownership.

I'll give you an example of this with some of the people that come to ask for health problems and health consulting and health optimisation. I can sort of pretty much tell in the first 10 minutes whether this person is taking ownership of the situation, or whether they're just blaming everybody else and they're angry about it, but they want a magic bullet. And the ones who want an instant fix in blaming everyone else and not taking ownership over the situation are very difficult to work with from a coaching perspective and also very unlikely to get great results. And will likely blame you in six week’s time because they didn't get the result.

And they will go through 10 coaches and they'll go through 20 coaches and they will still have no results at the end of it. And it’s not necessarily the coaches’ problems, or the health professional problem, it is often the fact that they are not taking ownership about the things that they can take ownership on, in educating themselves and working on it.

So you can start to work on pieces of the puzzle. You may have a big health issue, for example, and now we work with some people with some pretty serious freaking health issues. And when you can work on a piece of it today and this piece of it, and we can work like a detective, and we can work through problems, you don't have to tackle the whole thing at once. But it's being more aware, ‘Am I a person who goes through life blaming everybody else, blaming the system, blaming that? Or am I someone who does something about it? Takes ownership, start to make change in your own life, and affect what you can as well as trying to influence the world around you’? Does it make sense?

Neil: It makes perfect sense, Lisa. It really does. It's a great, great takeaway for the listeners, as well, just ask yourself that question, ‘Where am I at from a self-awareness perspective with regards to my own personal wellness’? And you can use those examples you just went through there, put a scale on it.

But we've got a great list of questions, Lisa. We can start to get the listeners to use to increase their awareness around their own stress. The thing we wanted to point out as well as we start to wrap things up is that everyone will respond to stress in a different way. So therefore, the way we respond to stress is going to be different. So therefore, the way we manage it is going to be different as well.

So as you're going through these questions, there's no right answer, there's no correct answer. It's an answer that should be individual to you and should be personal to you. So ask the question, What is the biggest stress you've got at the moment? And how is it expressing? What is the stress you're expressing in your body?

Number two, what normally causes stress for your body? So you'll be very aware how your body reacts and feels in different situations. So take time to listen to what it's saying, where you feel stress increasing, you feel your anxiety levels climb, and just feel your body tensing? If you start to get signs and symptoms—and again, it's going to be different for everybody and take note of them and do something about them. We work with so many people that get the signs and symptoms, but don't take note of them and don't do anything about them.

How's the stress showing up? Is it coming in certain environments? Is it around certain people? Is it around certain conversations? So again, ask that question, when is it showing up? When is it arriving? Can you change anything there to make sure it doesn't show up? And what can be done immediately to alleviate the feeling and to support your biology? You made the great reference earlier in the conversation about painting and what that does for you. For me going and moving and I know this works for you as well, Lisa, but going in and moving, getting something, going rhythmical is great for my mind. That could be walking, swimming, running, cycling doesn't have to be anything high intensity, but just movement helps massively. Rhythmical movement will help calm my body, calm my mind.

And what can those around you do to support you? Now as we've been throughout our career as coach and athlete, and now in business, we're very aware of how we can support each other. But that's taken time to have the conversations and work through it and talk to each other about it. I know you do with Haisley, and I do it with my wife, Sam. Once you understand those things, and we've set it up with the people we work with around us as well, it makes a massive difference. If people understand how to support you, and are aware that there's different ways that different people are going to get stressed—what stresses you is going to be different for me. So if I don't take the time to understand that, I'm going to be going through thinking, ‘Now it doesn't worry me, it's not going to worry Lisa’, and that work in both directions.

And number six, what can I do to manage my stress response better? So again, just asking the question would increase awareness. The fact that we're drawing attention to it increases awareness, which means we're more likely to do something about it. Then finally, what are the long-term strategies that I can implement to lower my residual stress? So once I work out the answers to the previous questions, then what can I do long term? And it could be as simple as we're big fans, as we always say, of what's the low hanging fruit? Is it simple now that I go to question five and go, right, ‘What can others do to support me? Am going to make those around me—my family, my friends, my close work colleagues—am I going to make them aware of what's causing me stress, so that they can help me and pull me up’?

Like we do with each other will often pull each other up and go, ‘Right. This is clearly getting a bit much’. Going this direction, we'll do this differently, or you give me time to do things and process things because you know that helps keep me calm. And when you're going fast and hard, I say well, ‘Time to slow down. It's great but you’re getting too excited, come back’. And that works for us. So increasing awareness really does help you get results rather than just accepting that, ‘I'm going to carry on with the back pain. I'm going to carry on the inflammation in my body. I'm going to carry on with the upset stomach. And not connect them back to something external that’s causing it.

Lisa: That’s a really good one because like I had a conversation with someone today and I've got repeated inflammation in the body, repeated pains in the neck, and then not connecting the dots. They connected one dot today that I went, ‘Hah, finally something is starting to drop’. When you are having pains every which way in the body, if your initial thing was to go, ‘Well, I've tweaked my back’. Instead of going, ‘Hang on, why am I having ongoing injuries? Or why am I having a stack of things happening to me? Or why am I getting pains here, and then I'm getting pains there, there's something underlying going on’.

And what we're saying is often that underlying thing is an inflammatory response is related to stress, very often you'll find a component at least of stress. And then it can you know, as we see, it can be from a food stress or toxins, through a psychological stress, from lack of movement, stress, or lack of sleep, dehydration, but these are all forms of stress. And so understanding what is the trigger and trying to connect the dots and this is where that self-awareness.

And in using these simple tools that we've been talking about on this podcast and other podcasts that we've done—the breath work stuff, the meditation stuff, and the movement stuff, the routines for habits, the healthy habits that you develop over time, and you start to stack one on another. And these little things that help you manage your biology, and help you manage your dopamine levels and your serotonin, all your good neurotransmitters, and your hormones and all these things. And it is about tweak, tweak, tweak, tweak, until your life starts to look better, feel better, and be better. And then it will be a constant thing. It's not like you're going to do this once and you're good to go.

Neil and I have a whole lot of tools in our kit that we can pull out in times of stress to help us get through. However, we're still going to have times when we tip out of balance, and then we need each other and their family members and other—my friends to put us back in the balance again, and just make us aware. It's not a one and done thing. It's a constant tweaking, learning, growing process, about trying to keep yourself in a good, a good state, both physically and mentally.

Neil: A lot more and more, Lisa. I'm asking people, it should be like with some of these things that you do to look after your body. It should be like brushing your teeth. I ask the people I'm working with one on one, I say, ‘Right, did you brush your teeth today’? Now know what I mean? I've asked two or three people, really say, ‘We brushed our teeth’. And what I meant was, ‘Have you done any mobility work? Have you done the breathing work and what's right for their biology? Have you been out, spent time in nature, and I might get responses like their response that they're actually a bit fluffy today.

But we do those things every day. And you talk about habit stacking. And it's exactly that. If you can brush your teeth every day, then you can do the other things that will control and maximize your health and do them as well, the simple little things, it’s not just about brushing your teeth. So let's start putting some other things in practice that do that crucial awareness. We don’t do it, isn’t it?

Lisa: We think we have to have the most expensive piece of equipment or the best supplement or the greatest course or—actually if we just did the basics right, often that will give us a good foundation. Yes, we can get fancy fancy stuff later and get more into it if you want to really tweak your biology which we love doing and testing and trialing and experimenting, but just getting those basics right. And yes, making it the underlying underpinning philosophy of your whole life, that has to be at the core of it. Health, looking after yourself has to be at the core of it, and it is not being selfish.

Again, I had someone else today, very stressful life, a lot going on. I’m telling them the same thing we can week out, they're coming back with this problem and that problem, and they're not hearing what's going on, and they're not willing to invest in the right things, or to buy the right foods, or to sit down and actually go through the process of actually making the small changes. Because they want the quick answer and you have to look after yourself and they also don't prioritise themselves. Everybody else comes before them.

And therefore they are going to be unhealthy ongoing until they can come to that point of self awareness that they have to be doing these small changes and getting the micronutrients and avoiding certain things and changing just little behaviors so that they can actually be a good father, a good husband, a good wife, a good friend, a good colleague, whatever the case may be, put your own oxygen mask on first before you help somebody else. It's not being selfish. So I think that's a pretty good place to wrap it up for today, isn't it Niel?

Neil: I agree. Agree. As always good chatting mate, good chatting.

Lisa: Good chatting. And if you enjoyed this, please let us know. We'd love to get here. You know what you thought about the shows that we're putting out, the information that we're putting out. We'd love to get comments and feedbacks, of course rating and reviews are always appreciated. But just yes, if it's helped you let us know.

If you want more information, and of course, we'd love to work with you. Reach out to us as we have our epigenetics program, which is all about understanding your genes and how they interact with the environment and how to optimise and getting rid of trial and error, and knowing what to do for your body. Then we also have our online run training programs, of course, which we love, training athletes, going and doing amazing things all around the place again, or a holistic approach to everything that we do.

So reach out to us, support@listamati.com. We'll find both new life and thanks for listening today. We really appreciate your time and attention. Any last comments, mate?

Neil: I’d like to say good chatting. We're looking forward to another conversation soon.

Lisa: Right. I'm going to go and do some movement in nature. Brilliant. We'll see you next week, everybody.

That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends and head over and visit Lisa and her team at lisatamati.com.

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Ep 52: Dr Susan Oldfield. 0

Jan 4, 2018

Dr Susan Oldfield hails originally from England and completed her medical training in the UK at UCL medical school, obtaining MBBS.

After this she went on to complete a Diploma in Family Planning as well as a Diploma in Obstetrics and Gynaecology, whilst completing her GP training and gaining the qualification MRCGP in the UK.

Her family and her decided to move to NZ in 2004. She then obtained GP qualifications in NZ, FRCGP.

Since then Susan has been working as a GP in a busy urban practice in New Plymouth.

She decided to pursue her interest in Integrative Medicine as she feels that combining a conventional approach with a more holistic approach provides clients with the best of both worlds. Because GP consultations are so time-limited, it is difficult to investigate problems in depth. With more time and an integrative approach, Susan is able to add much more to a consultation.

In this interview we discuss why the conventional medicine model wasn't working for her anymore, what an "Integrated Practitioner" means and what she sees coming in the future in the world of medicine, health and wellbeing.

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Ep 36: Epigenetics - The future of personalised health, fitness and understanding your uniqueness 0

Sep 29, 2017

Epigenetics is about to change the way we view our health and fitness, how we understand the expression of our genes.

But what is epigenetics? We won't go into the deep scientific defintion here rather look at how a particular assessment tool can help you interpret your own epigenetics and how it can improve your life, your health, fitness even your mindset, career direction and understand how you learn.

Cam McDonald of PH360 and Angela Jenkins an Epigenetics coach explain the background development of PH360 and online tool is directed at consumers and how it can personalise your approach to your health.

ph360 uses complex algorithms developed by researchers to translate the distinct relationship between your body’s measurements and physical traits to its physical functions, hormone secretions, metabolism, and lifestyle preferences, it uses anthropometry (scientific assessment of your body’s measurements), family history, and assessment of your lifestyle and environment to determine your phenotypic and epigenetic profile.

By taking this online assessment you get personally made reports for all areas of your life, which can help explain how you function.

It looks at the foods you should eat, the times when you most productive, the hours you should be sleeping, how you work best with other people, the way your mind functions and what you need to keep yourself balanced and happy. It gives you deep insights into your make up and truly personalises your approach to health and fitness.

We have a special offer for listeners. If you would like to take the assessment and find out more you can use the link below to get a huge discount on the assessment and a one on one coaching session with Angela Jenkins.

Usually priced at $377 AUD get the coaching and assessment and one year subscription to the platform for $197 AUD

Discount package for epigenetics testing and consult

For more information about Angela Jenkins and the Kaizen institute go to www.kaizenih.com

Dr Cam McDonald
Dr Cam is the Managing Director and lead trainer of PH360 Australia. He is a nutrition and exercise scientist. Dr Cam is best known for his work in the areas of genetics, coaching strategies, reversing chronic disease, and brain health.

Having spend the last 4 years transitioning his private practice clients from generic programs to fully tailored genetically-based programs, his clients with conditions like diabetes, heart disease, blood pressure and auto-immune conditions now live disease free and on a continual path to their optimal health. Those with a history of yo-yo dieting and stubborn, immovable weight have found the unique code that works for them, where nothing else did. Needless to say, these clients are very happy, refer lots of people and his client retention has gone through the roof!

For more information on Dr Cam and PH360 go to www.ph360.me

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Ep29: Trudy Northcott - Biohacker 0

Aug 31, 2017

Trudy Northcott has spent her life problem solving for her health sake. From age 8 Trudy had a rare spinal disorder which led to 30 years of pain and illness. She made it her mission to be responsible for her own body and get her health back against the so called "odds".

Now trained as a Bulletproof Coach Trudy helps others regain their own health as well as operating her online store www.energiseme.co.nz which specialises in products of integrity for a healthy mind and body.

With a history of learning what it takes to gain health back in this modern world the reality of stigma and discrimination was a huge block. In answer to this dilemma, Trudy felt compelled to be part of the solution instead of being a victim. As a result, she recently launched the community inspired project hughacker.com.

In this interview Lisa and Trudy discuss how to take control of your own health journey and not to just rely on pharmaceuticals for answers. They take an in-depth look into the biohacking phenomenon and ways to improve your life and wellbeing.

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Ep28: Dr Lindsey Berkson - Scientist, Hormone Scholar, Author 0

Aug 25, 2017

Hormone scholar, nutritionist, integrative gastrointestinal endocrine specialist, teacher of Doctors and author of 21 books, Dr. Lindsey Berkson, joins Lisa to discuss her everything hormones and health, breakthrough research and cutting edge information as well as discussing her new book, “Sexy Brain”. She explains how love is under attack, and the reasons why we’re all fighting a battle with our toxic environment.

From all things hormones, to the worst endocrine disruptors, to helpful tips for setting our hormones up for success

Dr Berkson is a thought leader in functional hormones. Her career spans more than four decades of research, clinical practice, authorship, teaching, pharmaceutical and nutraceutical investigation, and her own experience as a patient and survivor of multiple cancers in her early years. She knows what it's like to be on both sides of the health equation.
Berkson has been in on functional nutrition since its inception.
In this interview which we cover so much territory around hormones, brain health, nutrition, exercises, herbs and much more. Over 90 minutes of in-depth information from a world leading scholar. If you value your health you must listen in.

For Dr Berksons books, for consultations or speaking enquiries go to www.drlindseyberkson.com

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